Facile synthesis of a novel genetically encodable fluorescent α-amino acid emitting greenish blue light

A novel genetically encodable fluorescent l-α-amino acid 4-phenanthracen-9-yl-l-phenylalanine (Phen-AA) that emits greenish blue light and can be imaged in live cells has been synthesized under mild conditions in 3 steps with reasonably good yield.

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ChemInform Abstract: FACILE SYNTHESIS OF AMINO ACID AND PEPTIDE ESTERS UNDER MILD CONDITIONS VIA CESIUM SALTS

Chemischer Informationsdienst ◽

10.1002/chin.197734364 ◽

1977 ◽

Vol 8 (34) ◽

pp. no-no

Author(s):

S. S. WANG ◽

B. F. GISIN ◽

D. P. WINTER ◽

R. MAKOFSKE ◽

I. D. KULESHA ◽

...

Keyword(s):

Amino Acid ◽

Facile Synthesis ◽

Mild Conditions ◽

Cesium Salts ◽

Peptide Esters

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Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts

The Journal of Organic Chemistry ◽

10.1021/jo00428a004 ◽

1977 ◽

Vol 42 (8) ◽

pp. 1286-1290 ◽

Cited By ~ 193

Author(s):

Su-Sun Wang ◽

B. F. Gisin ◽

D. P. Winter ◽

R. Makofske ◽

I. D. Kulesha ◽

...

Keyword(s):

Amino Acid ◽

Facile Synthesis ◽

Mild Conditions ◽

Cesium Salts ◽

Peptide Esters

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Facile Synthesis of Enantioenriched Cγ-Tetrasubstituted α-Amino Acid Derivatives via an Asymmetric Nucleophilic Addition/Protonation Cascade

Organic Letters ◽

10.1021/ol200550y ◽

2011 ◽

Vol 13 (9) ◽

pp. 2290-2293 ◽

Cited By ~ 52

Author(s):

Shu-Wen Duan ◽

Jing An ◽

Jia-Rong Chen ◽

Wen-Jing Xiao

Keyword(s):

Amino Acid ◽

Nucleophilic Addition ◽

Amino Acid Derivatives ◽

Facile Synthesis

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ChemInform Abstract: Vilsmeier-Haack Reagent: A Facile Synthesis of 4-Heteromethylene-2- aryl-2-oxazolin-5-ones from N-Acyl-α-amino Acid Esters.

ChemInform ◽

10.1002/chin.199426151 ◽

2010 ◽

Vol 25 (26) ◽

pp. no-no

Author(s):

K. K. SINGH ◽

R. M. SINGH

Keyword(s):

Amino Acid ◽

Amino Acid Esters ◽

Facile Synthesis ◽

Acid Esters

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Eco-Friendly Synthesis of Sulphonic Acid Oxime Esters Catalyzed by 2-(1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.525.93 ◽

2014 ◽

Vol 525 ◽

pp. 93-96

Author(s):

Wei Shi ◽

Ji Ming Zhang ◽

Jian Hua Zhou ◽

Song Song Ding

Keyword(s):

High Selectivity ◽

Sulphonic Acid ◽

Present Approach ◽

High Yield ◽

Facile Synthesis ◽

Reaction Duration ◽

Mild Conditions ◽

Environmental Friendly

Herein we describle a facile synthesis of sulphonic acid oxime esters in acetonitrile from the corresponding sulphonic acids and oximes catalyzed by the environmental friendly 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) in the presence of triethylamine (TEA) under mild conditions. The present approach offers the advantages of a clean reaction, simple methodology, employing readily available catalyst, short reaction duration, high selectivity and high yield.

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Synthesis of New Chiral 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazines from α-Amino Acid Derivatives under Mild Conditions.

ChemInform ◽

10.1002/chin.200748151 ◽

2007 ◽

Vol 38 (48) ◽

Author(s):

Debendra K. Mohapatra ◽

Pradip K. Maity ◽

Rajesh G. Gonnade ◽

Mukund S. Chorghade ◽

Mukund K. Gurjar

Keyword(s):

Amino Acid ◽

Amino Acid Derivatives ◽

Mild Conditions

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Facile synthesis of 5-hydroxymethylfurfural: a sustainable raw material for the synthesis of key intermediates toward 21,23-dioxaporphyrins

RSC Advances ◽

10.1039/c5ra19400h ◽

2015 ◽

Vol 5 (121) ◽

pp. 100401-100407 ◽

Cited By ~ 11

Author(s):

Rajamani Rajmohan ◽

Subramaniyan Gayathri ◽

Pothiappan Vairaprakash

Keyword(s):

Room Temperature ◽

Solid Support ◽

Raw Material ◽

Facile Synthesis ◽

Mild Conditions

In a simple and conceptually designed method for the dehydration of fructose on a solid support, 5-hydroxymethylfurfural (HMF) was synthesized in more than 95% isolated yield from fructose under very mild conditions at room temperature.

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Aromatic Nucleophilic Nitrogen-Nitrogen Exchange Reaction ofN,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine with Amino Acid Derivatives: A Facile Synthesis of Fluorine-Containing 1H-Benzo[g]indolines and 1H-Benzo[g]indoles

Synthesis ◽

10.1055/s-1989-27315 ◽

1989 ◽

Vol 1989 (07) ◽

pp. 550-552 ◽

Cited By ~ 11

Author(s):

Masaru Hojo ◽

Ryōichi Masuda ◽

Etsuji Okada ◽

Hiroshi Miya

Keyword(s):

Amino Acid ◽

Exchange Reaction ◽

Amino Acid Derivatives ◽

Facile Synthesis ◽

Nitrogen Exchange

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Rational synthesis of an atomically precise carboncone under mild conditions

Science Advances ◽

10.1126/sciadv.aaw0982 ◽

2019 ◽

Vol 5 (8) ◽

pp. eaaw0982 ◽

Cited By ~ 7

Author(s):

Zheng-Zhong Zhu ◽

Zuo-Chang Chen ◽

Yang-Rong Yao ◽

Cun-Hao Cui ◽

Shu-Hui Li ◽

...

Keyword(s):

Apex Angle ◽

Facile Synthesis ◽

Reaction Conditions ◽

X Ray ◽

Carbon Allotropes ◽

X Ray Crystallography ◽

Mild Conditions ◽

Research Opportunity ◽

Insight Into ◽

Structural Strain

Carboncones, a special family of all-carbon allotropes, are predicted to have unique properties that distinguish them from fullerenes, carbon nanotubes, and graphenes. Owing to the absence of methods to synthesize atomically well-defined carboncones, however, experimental insight into the nature of pure carboncones has been inaccessible. Herein, we describe a facile synthesis of an atomically well-defined carboncone[1,2] (C70H20) and its soluble penta-mesityl derivative. Identified by x-ray crystallography, the carbon skeleton is a carboncone with the largest possible apex angle. Much of the structural strain is overcome in the final step of converting the bowl-shaped precursor into the rigid carboncone under mild reaction conditions. This work provides a research opportunity for investigations of atomically precise single-layered carboncones having even higher cone walls and/or smaller apex angles.

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