Intracellular mineralization of gold nanoparticles using gold ion-binding peptides with cell-penetrating ability

2021 ◽  
Author(s):  
Makoto Ozaki ◽  
Shuhei Yoshida ◽  
Takaaki Tsuruoka ◽  
Kenji Usui
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanostructures ◽  
Ion Binding ◽  
Cell Penetrating ◽  
Binding Peptides ◽  
Conventional Methods ◽  
Gold Ion

Our method can produce uniquely shaped gold nanostructures in lower HAuCl4 concentration than conventional methods by intracellular functions using peptide assembled structures as a template.

Rational Development of Cell-Penetrating High Affinity SH3 Domain Binding Peptides That Selectively Disrupt the Signal Transduction of Crk Family Adapters

1999 ◽  
Vol 886 (1 ANTICANCER MO) ◽  
pp. 289-292 ◽  
Author(s):  
CHRISTIAN KARDINAL ◽  
GUIDO POSERN ◽  
JIE ZHENG ◽  
BEATRICE S. KNUDSEN ◽  
ISMAIL MOAREFI ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Sh3 Domain ◽  
High Affinity ◽  
Rational Development ◽  
Cell Penetrating ◽  
Binding Peptides

DNA-Templated Gold Nanoparticles Formation

2008 ◽  
Vol 8 (9) ◽  
pp. 4415-4423 ◽  
Author(s):  
Lanlan Sun ◽  
Yonghai Song ◽  
Li Wang ◽  
Yujing Sun ◽  
Cunlan Guo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Reaction Time ◽  
Absorption Spectra ◽  
Reaction Temperature ◽  
Intermediate Product ◽  
Gold Nanostructures ◽  
Hybrid Nanoparticles ◽  
Reaction Conditions ◽  
Xps Spectra ◽  
Dna Concentration

The interaction between HAuCl4 and DNA has enabled creation of DNA-templated gold nanoparticles without formation of large nanoparticles. It was found that spheral DNA-HAuCl4 hybrid of 8.7nm in diameter, flower-like DNA-HAuCl4 hybrid, nanoparticles chains and nanoparticles network of DNA-HAuCl4 hybrid could be obtained by varying the reaction conditions, including DNA concentration and reaction temperature. The intermediate product was investigated by shortening the reaction time of DNA and HAuCl4, and the obtained nanoparticles preserved a small DNA segment, which indicated that the reaction between DNA and HAuCl4 had a process. The addition of reduction reagent resulted in DNA-templated gold nanoparticles and nanoflowers, respectively. UV-vis absorption spectra were used to characterize the DNA-HAuCl4 hybrid and the gold nanostructures templated on DNA, and XPS spectra were used to compare the composition of DNA-Au(III) complex and gold nanoparticles. AFM and TEM results revealed that the spheral gold nanoparticles of about 11 nm in size and flower-like gold nanoparticles were formed after the addition of NaBH4.

scholarly journals Synthesis and Study of Cell-Penetrating Peptide-Modified Gold Nanoparticles [Corrigendum]

2021 ◽  
Vol Volume 16 ◽  
pp. 4177-4178
Author(s):  
Félix Boussoufi ◽  
Sandra Navarro Gallón ◽  
Run Chang ◽  
Thomas Webster
Keyword(s):  
Gold Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Self-assembly of acetylcholinesterase on gold nanoparticles electrodeposited on graphite

2013 ◽  
Vol 11 (11) ◽  
pp. 1740-1748 ◽  
Author(s):  
Nina Dimcheva ◽  
Elena Horozova ◽  
Yavor Ivanov ◽  
Tzonka Godjevargova
Keyword(s):  
Gold Nanoparticles ◽  
Self Assembly ◽  
Enzyme Inhibitors ◽  
Gold Nanostructures ◽  
Electrochemical Biosensors ◽  
Organophosphorous Compound ◽  
Enzyme Immobilisation ◽  
Prospective Application ◽  
Acetylcholinesterase Enzyme

AbstractThe immobilisation of AChE enzyme through chemisorption on Au-modified graphite was examined with view of its prospective application in the design of membraneless electrochemical biosensors for the assay of enzyme inhibitors. The developed immobilisation protocol has been based on a two-stage procedure, comprising i) electrodeposition of gold nanostructures on spectroscopic graphite; followed by ii) chemisorption of the enzyme onto gold nanoparticles. Both the coverage of the electrode surface with Au nanostructures and the conditions for enzyme immobilisation were optimised. The proposed electrode architecture together with the specific type of enzyme immobilisation allow for a long-term retaining of the enzyme catalytic activity. The extent of inhibition of the immobilised acetylcholinesterase enzyme by the organophosphorous compound monocrotophos has been found to depend linearly on its concentration over the range from 50 to 400 nmol mL−1 with sensitivity 77.2% inhibition per 1 µmol mL−1 of monocrotophos.

scholarly journals Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

2019 ◽  
Vol 7 (1) ◽  
pp. 113-124 ◽  
Author(s):  
Yu-Sang Sabrina Yang ◽  
Kelly D. Moynihan ◽  
Ahmet Bekdemir ◽  
Tanmay M. Dichwalkar ◽  
Michelle M. Noh ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
T Cells ◽  
Small Molecule ◽  
Small Molecule Drugs ◽  
Cell Penetrating

We sought to develop a nanoparticle vehicle that could deliver small molecule drugs to T cells.

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