Diphenyl diselenide protects a Caenorhabditis elegans model for Huntington's disease by activation of the antioxidant pathway and a decrease in protein aggregation
Keyword(s):
The effect of (PhSe)2 in a C. elegans model for Huntington's disease. Treatment with (PhSe)2 triggered the nuclear translocation and activation of DAF-16 transcription factor in C. elegans, inducing the expression of superoxide dismutase-3 (SOD-3) and heat shock protein-16.2 (HSP-16.2). SOD-3 acts on reactive oxygen species (ROS) detoxification, and HSP-16.2 decreases protein misfolding and aggregation, which occur in HD.
2005 ◽
Vol 102
(34)
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pp. 12218-12223
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2011 ◽
Vol 208
(8)
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pp. i24-i24
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2011 ◽
Vol 18
(6)
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pp. 777-793
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2020 ◽
2005 ◽
Vol 102
(45)
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pp. 16530-16530
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2012 ◽
Vol 1
(2)
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pp. 211-219
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