Unusual chemistry of Cu(ii) salan complexes: synthesis, characterization and superoxide dismutase activity

2020 ◽  
Vol 44 (27) ◽  
pp. 11457-11470
Author(s):  
Satabdi Roy ◽  
Atanu Banerjee ◽  
Sudhir Lima ◽  
Adolfo Horn Jr ◽  
Raquel M. S. N. Sampaio ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cyclic Voltammetry ◽  
Spectral Characterization ◽  
Superoxide Dismutase Activity ◽  
Steric Effects ◽  
Ring Cleavage ◽  
Cyclic Voltammetry Data

Cu(ii)-salan complexes: structural and spectral characterization, solvent assisted ring cleavage and correlation of superoxide dismutase activity with cyclic voltammetry data and steric effects.

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

2020 ◽  
Vol 13 (1) ◽  
pp. 76-83
Author(s):  
Aline Maria Brito Lucas ◽  
Joana Varlla de Lacerda Alexandre ◽  
Maria Thalyne Silva Araújo ◽  
Cicera Edna Barbosa David ◽  
Yuana Ivia Ponte Viana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Cardiac Hypertrophy ◽  
Superoxide Dismutase Activity ◽  
Heart Weight ◽  
Pharmacological Intervention ◽  
Wall Thickening ◽  
H2o2 Production ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

Background: Cardiac hypertrophy involves marked wall thickening or chamber enlargement. If sustained, this condition will lead to dysfunctional mitochondria and oxidative stress. Mitochondria have ATP-sensitive K+ channels (mitoKATP) in the inner membrane that modulate the redox status of the cell. Objective: We investigated the in vivo effects of mitoKATP opening on oxidative stress in isoproterenol- induced cardiac hypertrophy. Methods: Cardiac hypertrophy was induced in Swiss mice treated intraperitoneally with isoproterenol (ISO - 30 mg/kg/day) for 8 days. From day 4, diazoxide (DZX - 5 mg/kg/day) was used in order to open mitoKATP (a clinically relevant therapy scheme) and 5-hydroxydecanoate (5HD - 5 mg/kg/day) or glibenclamide (GLI - 3 mg/kg/day) were used as mitoKATP blockers. Results: Isoproterenol-treated mice had elevated heart weight/tibia length ratios (HW/TL). Additionally, hypertrophic hearts had elevated levels of carbonylated proteins and Thiobarbituric Acid Reactive Substances (TBARS), markers of protein and lipid oxidation. In contrast, mitoKATP opening with DZX avoided ISO effects on gross hypertrophic markers (HW/TL), carbonylated proteins and TBARS, in a manner reversed by 5HD and GLI. Moreover, DZX improved mitochondrial superoxide dismutase activity. This effect was also blocked by 5HD and GLI. Additionally, ex vivo treatment of isoproterenol- induced hypertrophic cardiac tissue with DZX decreased H2O2 production in a manner sensitive to 5HD, indicating that this drug also acutely avoids oxidative stress. Conclusion: Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy. This pharmacological intervention could be a potential therapeutic strategy to prevent oxidative stress associated with cardiac hypertrophy.

scholarly journals Two New Compounds From the Heartwood of Dalbergia melanoxylon and Their Protective Effect on Hypoxia/Reoxygenation Injury in H9c2

2021 ◽  
Vol 16 (1) ◽  
pp. 1934578X2098777
Author(s):  
Yang Liu ◽  
Ni Zhang ◽  
Jun-wei He ◽  
Lan-ying Chen ◽  
Li Yang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Lactate Dehydrogenase ◽  
Protective Effect ◽  
Superoxide Dismutase Activity ◽  
Spectral Evidence ◽  
Reoxygenation Injury ◽  
Dalbergia Melanoxylon ◽  
New Compounds ◽  
Hypoxia Reoxygenation

A new neoflavonoid, named as (7 R)-(-)-3′,5-dihydroxy-4′,2,4-trimethoxy-dalbergiquinol (1) and a new phenanthrenedione, named as 3′,7-dihydroxy-3,6- dimethoxy-9-phenyl-1,4-phenanthrenedione (2), together with 4 known compounds, 5- O-methyldalbergiphenol (3), 3′,7-dihydroxy-4′,3,6-trimethoxy-9-phenyl-1,4-phenanthrenedione (4), (+)-obtusafuran (5), and melanoxin (6) were isolated from the heartwood of Dalbergia melanoxylon. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Moreover, compound 1 showed a protective effect on hypoxia/reoxygenation injury in H9c2 at 10.0 μM by decreasing lactate dehydrogenase and malondialdehyde activity and enhancing superoxide dismutase activity.

scholarly journals Severe reduction of superoxide dismutase activity in the yeastSaccharomyces cerevisaewith the deletion or overexpression ofGTS1

2003 ◽  
Vol 223 (1) ◽  
pp. 141-145 ◽  
Author(s):  
Abudokirim Abudugupur ◽  
Zhaojun Xu ◽  
Kazuhiro Mitsui ◽  
Harumi Hisaki ◽  
Nobuo Ueda ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Severe Reduction

scholarly journals A Germin-Like Protein Gene (CchGLP) of Capsicum chinense Jacq. Is Induced during Incompatible Interactions and Displays Mn-Superoxide Dismutase Activity

2011 ◽  
Vol 12 (11) ◽  
pp. 7301-7313 ◽  
Author(s):  
Fabiola León-Galván ◽  
Ahuizolt de Jesús Joaquín-Ramos ◽  
Irineo Torres-Pacheco ◽  
Ana P. Barba de la Rosa ◽  
Lorenzo Guevara-Olvera ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Protein Gene ◽  
Superoxide Dismutase Activity ◽  
Capsicum Chinense ◽  
Incompatible Interactions

scholarly journals Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity

2001 ◽  
Vol 76 (5) ◽  
pp. 1336-1345 ◽  
Author(s):  
Hiroshi Katsuki ◽  
Michiko Tomita ◽  
Chikako Takenaka ◽  
Hisashi Shirakawa ◽  
Seiichiro Shimazu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Dopaminergic Neurons ◽  
Superoxide Dismutase Activity

scholarly journals Antioxidant Capacity and Superoxide Dismutase Activity in Adrenoleukodystrophy

2017 ◽  
Vol 74 (5) ◽  
pp. 519 ◽  
Author(s):  
Bela R. Turk ◽  
Benjamin E. Theisen ◽  
Christina L. Nemeth ◽  
Joel S. Marx ◽  
Xiaohai Shi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Superoxide Dismutase Activity
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