scholarly journals Two New Compounds From the Heartwood of Dalbergia melanoxylon and Their Protective Effect on Hypoxia/Reoxygenation Injury in H9c2

2021 ◽  
Vol 16 (1) ◽  
pp. 1934578X2098777
Author(s):  
Yang Liu ◽  
Ni Zhang ◽  
Jun-wei He ◽  
Lan-ying Chen ◽  
Li Yang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Lactate Dehydrogenase ◽  
Protective Effect ◽  
Superoxide Dismutase Activity ◽  
Spectral Evidence ◽  
Reoxygenation Injury ◽  
Dalbergia Melanoxylon ◽  
New Compounds ◽  
Hypoxia Reoxygenation

A new neoflavonoid, named as (7 R)-(-)-3′,5-dihydroxy-4′,2,4-trimethoxy-dalbergiquinol (1) and a new phenanthrenedione, named as 3′,7-dihydroxy-3,6- dimethoxy-9-phenyl-1,4-phenanthrenedione (2), together with 4 known compounds, 5- O-methyldalbergiphenol (3), 3′,7-dihydroxy-4′,3,6-trimethoxy-9-phenyl-1,4-phenanthrenedione (4), (+)-obtusafuran (5), and melanoxin (6) were isolated from the heartwood of Dalbergia melanoxylon. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Moreover, compound 1 showed a protective effect on hypoxia/reoxygenation injury in H9c2 at 10.0 μM by decreasing lactate dehydrogenase and malondialdehyde activity and enhancing superoxide dismutase activity.

scholarly journals The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells

Renal Failure ◽  
2014 ◽  
Vol 36 (9) ◽  
pp. 1449-1454 ◽  
Author(s):  
Lei Wang ◽  
Hui Chen ◽  
Xiu-Heng Liu ◽  
Zhi-Yuan Chen ◽  
Xiao-Dong Weng ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Kidney ◽  
Kidney Cells ◽  
Reoxygenation Injury ◽  
Hypoxia Reoxygenation

Propofol Displays No Protective Effect Against Hypoxia/Reoxygenation Injury in Rat Liver Slices

2003 ◽  
Vol 97 (2) ◽  
pp. 442-448 ◽  
Author(s):  
Hiroo Shimono ◽  
Teruko Goromaru ◽  
Yoshitami Kadota ◽  
Takeshi Tsurumaru ◽  
and Yuichi Kanmura
Keyword(s):  
Protective Effect ◽  
Rat Liver ◽  
Liver Slices ◽  
Reoxygenation Injury ◽  
Hypoxia Reoxygenation

Effect of nickel chloride on streptozotocin-induced diabetes in rats

1988 ◽  
Vol 66 (5) ◽  
pp. 663-665 ◽  
Author(s):  
Ethel L. B. Novelli ◽  
Ney L. Rodrigues ◽  
Bartolomé O. Ribas
Keyword(s):  
Superoxide Dismutase ◽  
Body Weight ◽  
Single Dose ◽  
Protective Effect ◽  
Plasma Insulin ◽  
Nickel Chloride ◽  
Superoxide Dismutase Activity ◽  
Streptozotocin Induced Diabetes

The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, protein, and Cu–Zn superoxide dismutase activity. In rats treated with nickel chloride (10 mg/kg body weight) and streptozotocin, these values were comparable with those observed in control rats. The results indicate that nickel chloride injected before streptozotocin prevented streptozotocin-induced hyperglycemia, and suggest that the protective effect was related to Cu–Zn superoxide dismutase activity, mediated by copper.

Isoflurane Attenuates Early Neutrophil-independent Hypoxia-Reoxygenation Injuries in the Reperfused Liver in Fasted Rats

1997 ◽  
Vol 86 (1) ◽  
pp. 128-136 ◽  
Author(s):  
Shinpei Kon ◽  
Mie Imai ◽  
Hideo Inaba
Keyword(s):  
Lactate Dehydrogenase ◽  
Kupffer Cells ◽  
Minimum Alveolar Concentration ◽  
Ischemia Reperfusion ◽  
Gas Mixture ◽  
Superoxide Generation ◽  
Lactate Dehydrogenase Release ◽  
Carbon Dioxide Gas ◽  
Reoxygenation Injury ◽  
Hypoxia Reoxygenation

Background Ischemia-hypoxia followed by reperfusion and reoxygenation injures cells and organs. Previous studies have indicated that isoflurane may protect organs from ischemia-reperfusion or hypoxia-reoxygenation. This study investigated the ability of isoflurane to protect the liver from hypoxia-reoxygenation injury and the mechanisms of this phenomenon. Methods The isolated liver was perfused at a constant pressure of 12 cm H2O with a modified Krebs-Ringer-bicarbonate solution saturated with a 95% oxygen/5% carbon dioxide gas mixture. Hypoxic perfusion produced by decreasing the oxygen concentration in the gas mixture to 10% was followed by perfusion at 95% oxygen for 60 min. Viability of the liver was assessed by lactate dehydrogenase release from the liver. Isoflurane at 0.5, 1, and 2 minimum alveolar concentration was administered to assess the effect of isoflurane on hypoxia-reperfusion injury. To determine the effect of isoflurane on extracellular generation of superoxide in the liver, the reduction of ferricytochrome c with or without superoxide dismutase was measured. Results Lactate dehydrogenase release was transiently but dramatically increased by reoxygenation and significantly attenuated by 1 and 2 minimum alveolar concentration of isoflurane. Suppression of Kupffer cells with gadolinium chloride also attenuated the lactate dehydrogenase release. Isoflurane significantly reduced the superoxide generation on reperfusion. Conclusions The results show that isoflurane protected the liver from an early reoxygenation injury presumably mediated by Kupffer cells. The mechanisms of the inhibitory effects of isoflurane on the injury may involve suppression of extracellular superoxide generation during reoxygenation.

scholarly journals Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes

2004 ◽  
Vol 142 (3) ◽  
pp. 618-626 ◽  
Author(s):  
Masahiro Yamawaki ◽  
Norihito Sasaki ◽  
Masaki Shimoyama ◽  
Junichiro Miake ◽  
Kazuhide Ogino ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reoxygenation Injury ◽  
Hypoxia Reoxygenation
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