Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses

2021 ◽  
Author(s):  
Zhengyan Guo ◽  
Yue Tang ◽  
Wei Tang ◽  
Yihua Chen
Keyword(s):  
Natural Products ◽  
Animal Diseases ◽  
Human And Animal Diseases

Heptose-containing natural products hold great potential as drugs for the treatment of human and animal diseases.

scholarly journals Culicoides insignis Lutz, 1913 (Diptera: Ceratopogonidae) Biting Midges in Northeast of Brazil

Insects ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 366
Author(s):  
Raisa Rodrigues Santos Rios ◽  
Maria Clara Alves Santarém ◽  
Karlos Antônio Lisboa Ribeiro Júnior ◽  
Breno Araujo de Melo ◽  
Sybelle Georgia Mesquita da Silva ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Dna Sequencing ◽  
Control Strategies ◽  
Northeast Brazil ◽  
Light Traps ◽  
Biting Midges ◽  
Animal Diseases ◽  
Local Species ◽  
Specific Species ◽  
Human And Animal Diseases

The species of the Culicoides genus are hematophagous, and some of them are vectors of important human and animal diseases. This group of insects is distributed worldwide, varying according to local species. Knowledge of the geographic distribution of specific species is crucial for the development and implementation of control strategies. The aim of this work was to investigate the occurrence of Culicoides in the state of Alagoas in northeast Brazil. Midges were captured with CDC light traps, and their identification and morphological analyses were performed by the Ceratopogonidae Collection of the Oswaldo Cruz Foundation (FIOCRUZ/CCER) in Rio de Janeiro, Brazil. Morphological analyses were performed using the key to Culicoides from the guttatus group and comparison with other deposited specimens. DNA sequencing, genetic analysis and comparison with sequences in the Genbank database, confirmed the identification of the flies as Culicoides insignis. This was the first formal report of C. insignis being found in Alagoas.

scholarly journals A PCR-RFLP assay for the detection and differentiation of Campylobacter jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis

2014 ◽  
Vol 63 (5) ◽  
pp. 659-666 ◽  
Author(s):  
Kazumasa Kamei ◽  
Masahiro Asakura ◽  
Srinuan Somroop ◽  
Noritoshi Hatanaka ◽  
Atsushi Hinenoya ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Sensitivity And Specificity ◽  
Gastrointestinal Diseases ◽  
Campylobacter Coli ◽  
Cytolethal Distending Toxin ◽  
Restriction Digestion ◽  
Animal Diseases ◽  
Pcr Rflp ◽  
Rflp Assay ◽  
Human And Animal Diseases

Although Campylobacter jejuni and Campylobacter coli are the most common bacterial causes of human gastrointestinal diseases, other Campylobacter species are also involved in human and animal infections. In this study, we developed a cytolethal distending toxin (cdt) gene-based PCR-RFLP assay for the detection and differentiation of C. jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis. Previously designed common primers, which can amplify the cdtB gene of C. jejuni, C. coli and C. fetus, were used for detecting seven Campylobacter species and differentiating between them by restriction digestion. The PCR-RFLP assay was validated with 277 strains, including 35 C. jejuni, 19 C. coli, 20 C. fetus, 24 C. hyointestinalis, 13 C. lari, 2 C. helveticus, 22 C. upsaliensis, 3 other Campylobacter spp. and 17 other species associated with human diseases. Sensitivity and specificity of the PCR-RFLP assay were 100 % except for C. hyointestinalis (88 % sensitivity). Furthermore, the PCR-RFLP assay successfully detected and differentiated C. jejuni, C. coli and C. fetus in clinical and animal samples. The results indicate that the PCR-RFLP assay is useful for the detection and differentiation of seven Campylobacter species important for human and animal diseases.

scholarly journals Toxigenic clostridia.

1990 ◽  
Vol 3 (1) ◽  
pp. 66-98 ◽  
Author(s):  
C L Hatheway
Keyword(s):  
Amino Acid ◽  
Biological Activities ◽  
Amino Acid Sequences ◽  
Biologically Active ◽  
Antigenic Protein ◽  
Historical Aspects ◽  
Biochemical Characteristics ◽  
Animal Diseases ◽  
Human And Animal Diseases ◽  
Binary Toxins

Toxigenic clostridia belonging to 13 recognized species are discussed in this review. Each species or group of organisms is, in general, introduced by presenting the historical aspects of its discovery by early investigators of human and animal diseases. The diseases caused by each species or group are described and usually discussed in relation to the toxins involved in the pathology. Morphological and physiological characteristics of the organisms are described. Finally, the toxins produced by each organism are listed, with a presentation of their biological activities and physical and biochemical characteristics. The complete amino acid sequences for some are known, and some of the genes have been cloned. The term toxin is used loosely to include the various antigenic protein products of these organisms with biological and serological activities which have served as distinguishing characteristics for differentiation and classification. Some of these factors are not truly toxic and have no known role in pathogenicity. Some of the interesting factors common to more than one species or group are the following: neurotoxins, lethal toxins, lecithinases, oxygen-labile hemolysins, binary toxins, and ADP-ribosyltransferases. Problems in bacterial nomenclature and designation of biologically active factors are noted.

Progress on Nucleic Acid-Based Vaccines for the Control of Human and Animal Diseases

1999 ◽  
Vol 28 (4) ◽  
pp. 245-252
Author(s):  
Theophanis S. Kanellos ◽  
A.G. Ambali ◽  
Peter H. Russell
Keyword(s):  
Nucleic Acid ◽  
Animal Diseases ◽  
Human And Animal Diseases

Protein Kinases as Drug Targets in Human and Animal Diseases

2017 ◽  
Vol 13 (2) ◽  
Author(s):  
Suvarna G. Kini ◽  
Vikas Garg ◽  
Sharada Prasanna ◽  
Revathi Rajappan ◽  
Muhammad Mubeen
Keyword(s):  
Protein Kinases ◽  
Drug Targets ◽  
Animal Diseases ◽  
Human And Animal Diseases

The Changing Image of Mycoplasmas: From Innocent Bystanders to Emerging and Reemerging Pathogens in Human and Animal Diseases

2001 ◽  
pp. 166-185 ◽  
Author(s):  
R. Rosengarten ◽  
C. Citti ◽  
P. Much ◽  
J. Spergser ◽  
M. Droesse ◽  
...  
Keyword(s):  
Animal Diseases ◽  
Human And Animal Diseases
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