Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives
2020 ◽
Vol 18
(23)
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pp. 4376-4380
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Keyword(s):
One Pot
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A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base.