scholarly journals Influence of the physicochemical features of TiO2 nanoparticles on the formation of a protein corona and impact on cytotoxicity

RSC Advances ◽  
2020 ◽  
Vol 10 (72) ◽  
pp. 43950-43959
Author(s):  
Ozge Kose ◽  
Marion Stalet ◽  
Lara Leclerc ◽  
Valérie Forest
Keyword(s):  
Tio2 Nanoparticles ◽  
Human Lung ◽  
Protein Corona ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Potential Relationship ◽  
Physicochemical Features

Characterization of the formation of the protein corona of TiO2 nanoparticles as a function of the main nanoparticle properties and investigation of potential relationship with the cytotoxicity nanoparticles induce in vitro in human lung cells.

Quantitation and characterization of leukotriene products released following immunologic stimulation of human lung cells in vitro

CHEST Journal ◽  
1983 ◽  
Vol 83 (5) ◽  
pp. 81S-82 ◽  
Author(s):  
A. G. Leitch ◽  
R. A. Lewis ◽  
E. J. Corey ◽  
K. F. Austen
Keyword(s):  
Human Lung ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Stimulation Of

Quantitation and Characterization of Leukotriene Products Released following Immunologic Stimulation of Human Lung Cells in Vitro

CHEST Journal ◽  
1983 ◽  
Vol 83 (5) ◽  
pp. 81S-82S ◽  
Author(s):  
AG. Leitch ◽  
R.A Lewis ◽  
E.J. Corey ◽  
K.E Austen
Keyword(s):  
Human Lung ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Stimulation Of

scholarly journals Polyphosphate Reverses the Toxicity of the Quasi-Enzyme Bleomycin on Alveolar Endothelial Lung Cells In Vitro

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 750
Author(s):  
Werner E. G. Müller ◽  
Meik Neufurth ◽  
Shunfeng Wang ◽  
Heinz C. Schröder ◽  
Xiaohong Wang
Keyword(s):  
Dna Damage ◽  
Human Lung ◽  
Dna Integrity ◽  
Lung Cells ◽  
Antitumor Antibiotic ◽  
Cell Toxicity ◽  
Inorganic Polyphosphate ◽  
Human Lung Cells ◽  
Anti Cancer

The anti-cancer antitumor antibiotic bleomycin(s) (BLM) induces athyminic sites in DNA after its activation, a process that results in strand splitting. Here, using A549 human lung cells or BEAS-2B cells lunc cells, we show that the cell toxicity of BLM can be suppressed by addition of inorganic polyphosphate (polyP), a physiological polymer that accumulates and is released from platelets. BLM at a concentration of 20 µg ml−1 causes a decrease in cell viability (by ~70%), accompanied by an increased DNA damage and chromatin expansion (by amazingly 6-fold). Importantly, the BLM-caused effects on cell growth and DNA integrity are substantially suppressed by polyP. In parallel, the enlargement of the nuclei/chromatin in BLM-treated cells (diameter, 20–25 µm) is normalized to ~12 µm after co-incubation of the cells with BLM and polyP. A sequential application of the drugs (BLM for 3 days, followed by an exposure to polyP) does not cause this normalization. During co-incubation of BLM with polyP the gene for the BLM hydrolase is upregulated. It is concluded that by upregulating this enzyme polyP prevents the toxic side effects of BLM. These data might also contribute to an application of BLM in COVID-19 patients, since polyP inhibits binding of SARS-CoV-2 to cellular ACE2.

scholarly journals TiO2 nanoparticles generate superoxide and alter gene expression in human lung cells

RSC Advances ◽  
2019 ◽  
Vol 9 (43) ◽  
pp. 25039-25047 ◽  
Author(s):  
Dhanya T. Jayaram ◽  
Ashwath Kumar ◽  
Linda E. Kippner ◽  
Po-Yi Ho ◽  
Melissa L. Kemp ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fluorescence Microscopy ◽  
Tio2 Nanoparticles ◽  
Human Lung ◽  
Lung Cells ◽  
Rna Seq ◽  
Nanoparticle Exposure ◽  
Human Lung Cells

Human lung cells have a multi-generational response to TiO2 nanoparticle exposure determined by RNA-Seq and fluorescence microscopy.

Pathobiological Effects of Fibers and Tobacco-Related Chemicals in Human Lung Cells In Vitro

1989 ◽  
pp. 103-117
Author(s):  
C. C. Harris ◽  
J. C. Willey ◽  
N. Matsukura ◽  
J. F. Lechner ◽  
M. Miyashita ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Cells ◽  
Human Lung Cells

Genomic responses of human lung cells exposure through a successful in vitro field deployment in Houston, Texas

2017 ◽  
Vol 280 ◽  
pp. S212
Author(s):  
Hang Nguyen ◽  
Kenneth Sexton ◽  
Lisa Smeester ◽  
Kjersti Marie Aagaard ◽  
Cynthia Do Shope ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Field Deployment

scholarly journals Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes

2018 ◽  
Vol 12 (2) ◽  
pp. 138-152 ◽  
Author(s):  
Santosh Phuyal ◽  
Mayes Kasem ◽  
Oskar Knittelfelder ◽  
Animesh Sharma ◽  
Davi de Miranda Fonseca ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Multiwalled Carbon Nanotubes ◽  
Chronic Exposure ◽  
Low Dose ◽  
Human Lung ◽  
Lung Cells ◽  
Multiwalled Carbon ◽  
Human Lung Cells
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