Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

2020 ◽  
Vol 5 (9) ◽  
pp. 1527-1555 ◽  
Author(s):  
Zsolt Fülöp ◽  
Péter Szemesi ◽  
Péter Bana ◽  
János Éles ◽  
István Greiner
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Design Strategies ◽  
Flow Synthesis ◽  
Pharmaceutical Ingredients ◽  
Continuous Preparation

This review focuses on the flow-oriented design (FOD) in the multi-step continuous-flow synthesis of active pharmaceutical ingredients.

scholarly journals Flow Synthesis Kinetics for Lomustine, an Anti-Cancer Active Pharmaceutical Ingredient

2021 ◽  
Author(s):  
Samir Diab ◽  
Mateen Raiyat ◽  
Dimitrios I. Gerogiorgis
Keyword(s):  
Heat Transfer ◽  
Continuous Flow ◽  
Active Pharmaceutical Ingredient ◽  
Process Conditions ◽  
Active Pharmaceutical Ingredients ◽  
Batch Mode ◽  
Flow Synthesis ◽  
Pharmaceutical Ingredients ◽  
Anti Cancer

Continuous flow synthesis of Active Pharmaceutical Ingredients (APIs) can offer access to process conditions that are otherwise hazardous when operated in batch mode, resulting in improved mixing and heat transfer,...

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

2019 ◽  
Vol 4 (4) ◽  
pp. 652-657 ◽  
Author(s):  
Péter Bana ◽  
Áron Szigetvári ◽  
János Kóti ◽  
János Éles ◽  
István Greiner
Keyword(s):  
Continuous Flow ◽  
Drug Substance ◽  
Flow Synthesis ◽  
Continuous Preparation

The first integrated continuous-flow synthesis of the drug substance flibanserin was developed, using an uninterrupted four-step sequence, via an unprecedented route.

scholarly journals Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

2020 ◽  
Vol 5 (7) ◽  
pp. 1186-1197 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Mathilde A. C. H. Janssen ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Flow Processes ◽  
Selection Of

This review highlights a selection of multistep continuous flow (one-flow) processes leading to the synthesis of active pharmaceutical ingredients (APIs).

Continuous flow upgrading of glycerol toward oxiranes and active pharmaceutical ingredients thereof

2019 ◽  
Vol 21 (16) ◽  
pp. 4422-4433 ◽  
Author(s):  
Romain Morodo ◽  
Romaric Gérardy ◽  
Guillaume Petit ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Amino Alcohol ◽  
Continuous Flow ◽  
Value Added ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

A robust continuous flow procedure for the transformation of bio-based glycerol into high value-added β-amino alcohol active pharmaceutical ingredients.

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

2019 ◽  
Vol 17 (6) ◽  
pp. 1552-1557 ◽  
Author(s):  
Renata M. Aguiar ◽  
Raquel A. C. Leão ◽  
Alejandro Mata ◽  
David Cantillo ◽  
C. Oliver Kappe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Continuous Flow ◽  
Building Blocks ◽  
Active Pharmaceutical Ingredients ◽  
Enantiomerically Pure ◽  
Pharmaceutical Ingredients ◽  
Chiral Intermediates

Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building blocks.

Selectivity engineering of the diazotization reaction in a continuous flow reactor

2016 ◽  
Vol 1 (4) ◽  
pp. 387-396 ◽  
Author(s):  
C. A. Shukla ◽  
A. A. Kulkarni ◽  
V. V. Ranade
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Diazonium Salts ◽  
Fine Chemicals ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Reactor

In situ generated diazonium salts are useful intermediates for the synthesis of fine chemicals and active pharmaceutical ingredients. This paper presents a methodology for selectivity engineering of the diazotization reaction in continuous reactors.

Sign in / Sign up

Export Citation Format

Share Document