scholarly journals A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase

2021 ◽  
Author(s):  
Lin Zhang ◽  
Eckhard Bill ◽  
Peter M. H. Kroneck ◽  
Oliver Einsle
Keyword(s):  
Nitrous Oxide ◽  
Active Site ◽  
Structural Flexibility ◽  
Nitrous Oxide Reductase ◽  
Metal Site ◽  
And Function ◽  
Insight Into

Variants of all seven histidine ligands of the [4Cu:2S] active site of nitrous oxide reductase mostly result in loss of the metal site. However, a H382A variant retains a [3Cu:2S] cluster that hints towards a structural flexibility also present in the intact site.

Insight into Catalysis of Nitrous Oxide Reductase from High-resolution Structures of Resting and Inhibitor-bound Enzyme from Achromobacter cycloclastes

2006 ◽  
Vol 362 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Konstantinos Paraskevopoulos ◽  
Svetlana V. Antonyuk ◽  
R. Gary Sawers ◽  
Robert R. Eady ◽  
S. Samar Hasnain
Keyword(s):  
Nitrous Oxide ◽  
High Resolution ◽  
Nitrous Oxide Reductase ◽  
Achromobacter Cycloclastes ◽  
Insight Into

Insight into the active-site structure and function of cytochrome oxidase by analysis of site-directed mutants of bacterial cytochromeaa 3 and cytochromebo

1993 ◽  
Vol 25 (2) ◽  
pp. 121-136 ◽  
Author(s):  
Jonathan P. Hosler ◽  
Shelagh Ferguson-Miller ◽  
Melissa W. Calhoun ◽  
Jeffrey W. Thomas ◽  
John Hill ◽  
...  
Keyword(s):  
Cytochrome Oxidase ◽  
Active Site ◽  
Structure And Function ◽  
Site Structure ◽  
Active Site Structure ◽  
And Function ◽  
Insight Into

scholarly journals The tetranuclear copper active site of nitrous oxide reductase: the CuZ center

2011 ◽  
Vol 16 (2) ◽  
pp. 183-194 ◽  
Author(s):  
Simone Dell’Acqua ◽  
Sofia R. Pauleta ◽  
Isabel Moura ◽  
José J. G. Moura
Keyword(s):  
Nitrous Oxide ◽  
Active Site ◽  
Nitrous Oxide Reductase

scholarly journals Protonation state of the Cu4S2CuZsite in nitrous oxide reductase: redox dependence and insight into reactivity

2015 ◽  
Vol 6 (10) ◽  
pp. 5670-5679 ◽  
Author(s):  
Esther M. Johnston ◽  
Simone Dell'Acqua ◽  
Sofia R. Pauleta ◽  
Isabel Moura ◽  
Edward I. Solomon
Keyword(s):  
Electron Transfer ◽  
Nitrous Oxide ◽  
Redox State ◽  
Nitrous Oxide Reductase ◽  
Protonation State ◽  
Proton Coupled Electron Transfer ◽  
Insight Into

The edge ligand in the Cu4S2CuZform of nitrous oxide reductase is a μ2-thiolate in the 1-hole and a μ2-sulfide in the 2-hole redox state, leading to proton-coupled electron transfer reactivity.

Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase

2020 ◽  
Author(s):  
Vikram V. Shende ◽  
Yogan Khatri ◽  
Sean A. Newmister ◽  
Jacob N. Sanders ◽  
Petra Lindovska ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Active Site ◽  
Structure And Function ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Bond Forming ◽  
And Function ◽  
Insight Into

This report details the discovery and characterization of a versatile bacterial cytochrome P450, NzeB, which catalyzes the dimerization of diketopiperazines via enzymatic C–H functionalization. This includes the first high-resolution crystal structure of a diketopiperazine dimerase, which along with active site via mutagenesis and quantum mechanical calculations, provides insight into the selectivity and mechanism of these enzymes.

scholarly journals Assembly, Structure, and Reactivity of Cu4S and Cu3S Models for the Nitrous Oxide Reductase Active Site, CuZ*

2014 ◽  
Vol 53 (19) ◽  
pp. 10611-10619 ◽  
Author(s):  
Brittany J. Johnson ◽  
Sergey V. Lindeman ◽  
Neal P. Mankad
Keyword(s):  
Nitrous Oxide ◽  
Active Site ◽  
Nitrous Oxide Reductase ◽  
Assembly Structure

scholarly journals Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase

2020 ◽  
Author(s):  
Vikram V. Shende ◽  
Yogan Khatri ◽  
Sean A. Newmister ◽  
Jacob N. Sanders ◽  
Petra Lindovska ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Active Site ◽  
Structure And Function ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Bond Forming ◽  
And Function ◽  
Insight Into

This report details the discovery and characterization of a versatile bacterial cytochrome P450, NzeB, which catalyzes the dimerization of diketopiperazines via enzymatic C–H functionalization. This includes the first high-resolution crystal structure of a diketopiperazine dimerase, which along with active site via mutagenesis and quantum mechanical calculations, provides insight into the selectivity and mechanism of these enzymes.

N2O reduction at a dissymmetric {Cu2S}-containing mixed-valent center

2014 ◽  
Vol 5 (12) ◽  
pp. 4774-4784 ◽  
Author(s):  
Charlène Esmieu ◽  
Maylis Orio ◽  
Stéphane Torelli ◽  
Laurent Le Pape ◽  
Jacques Pécaut ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Active Site ◽  
Room Temperature ◽  
Nitrous Oxide Reductase ◽  
N2o Reduction

Through a bio-inspired approach of the active site of the metalloenzyme nitrous oxide reductase, we isolated and characterized a dinuclear mixed-valent dicopper complex capable of N2O reduction at room temperature.

Insight into the structural flexibility and function of Mycobacterium tuberculosis isocitrate lyase

Biochimie ◽  
2015 ◽  
Vol 110 ◽  
pp. 73-80 ◽  
Author(s):  
Harish Shukla ◽  
Vikash Kumar ◽  
Amit Kumar Singh ◽  
Neha Singh ◽  
Md. Kashif ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Isocitrate Lyase ◽  
Structural Flexibility ◽  
And Function ◽  
Insight Into
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