Combined royal jelly 10-hydroxydecanoic acid and aspirin is synergistic against memory deficit and neuroinflammation

2022 ◽  
Author(s):  
Mengmeng You ◽  
Kangli Wang ◽  
Yongming Pan ◽  
Lingchen Tao ◽  
Quan-xin Ma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Inflammation ◽  
Royal Jelly ◽  
Memory Deficit ◽  
Older Population ◽  
Inflammatory Drug ◽  
Neurodegenerative Dementia ◽  
Anti Inflammatory

Alzheimer’s disease (AD), the most common form of neurodegenerative dementia among the older population, is associated with acute or chronic inflammation. As a nonsteroidal anti-inflammatory drug, aspirin has recently been...

Consideration of a Pharmacological Combinatorial Approach to Inhibit Chronic Inflammation in Alzheimer’s Disease

2019 ◽  
Vol 16 (11) ◽  
pp. 1007-1017 ◽  
Author(s):  
James G. McLarnon
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Chronic Inflammation ◽  
Preventive Strategy ◽  
Subsequent Work ◽  
Activated Microglia ◽  
Starting Point ◽  
Anti Inflammatory ◽  
Cocktail Approach

A combinatorial cocktail approach is suggested as a rationale intervention to attenuate chronic inflammation and confer neuroprotection in Alzheimer’s disease (AD). The requirement for an assemblage of pharmacological compounds follows from the host of pro-inflammatory pathways and mechanisms present in activated microglia in the disease process. This article suggests a starting point using four compounds which present some differential in anti-inflammatory targets and actions but a commonality in showing a finite permeability through Blood-brain Barrier (BBB). A basis for firstchoice compounds demonstrated neuroprotection in animal models (thalidomide and minocycline), clinical trial data showing some slowing in the progression of pathology in AD brain (ibuprofen) and indirect evidence for putative efficacy in blocking oxidative damage and chemotactic response mediated by activated microglia (dapsone). It is emphasized that a number of candidate compounds, other than ones suggested here, could be considered as components of the cocktail approach and would be expected to be examined in subsequent work. In this case, systematic testing in AD animal models is required to rigorously examine the efficacy of first-choice compounds and replace ones showing weaker effects. This protocol represents a practical approach to optimize the reduction of microglial-mediated chronic inflammation in AD pathology. Subsequent work would incorporate the anti-inflammatory cocktail delivery as an adjunctive treatment with ones independent of inflammation as an overall preventive strategy to slow the progression of AD.

Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

2001 ◽  
Vol 25 (7) ◽  
pp. 1341-1357 ◽  
Author(s):  
Anthony C. Allison ◽  
Ramon Cacabelos ◽  
Valter R.M. Lombardi ◽  
Xoan A. Álvarez ◽  
Carmen Vigo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Anti-inflammatory drug studies in Alzheimer's disease

1996 ◽  
Vol 39 (7) ◽  
pp. 563
Author(s):  
P.S. Aisen ◽  
D. Marin ◽  
K.L. Davis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Drug Studies

Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease

2012 ◽  
Vol 8 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Sharlène Côté ◽  
Pierre-Hugues Carmichael ◽  
René Verreault ◽  
Joan Lindsay ◽  
Jean Lefebvre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Drug Use ◽  
Inflammatory Drug ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document