Cytokine and Anti-Inflammatory Drug Effects on Brain Trauma and Alzheimer’s Disease Pathology in Transgenic Mice

2000 ◽  
pp. 139-151
Author(s):  
P. H. Patterson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Drug Effects ◽  
Brain Trauma ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

2001 ◽  
Vol 25 (7) ◽  
pp. 1341-1357 ◽  
Author(s):  
Anthony C. Allison ◽  
Ramon Cacabelos ◽  
Valter R.M. Lombardi ◽  
Xoan A. Álvarez ◽  
Carmen Vigo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Combined royal jelly 10-hydroxydecanoic acid and aspirin is synergistic against memory deficit and neuroinflammation

2022 ◽  
Author(s):  
Mengmeng You ◽  
Kangli Wang ◽  
Yongming Pan ◽  
Lingchen Tao ◽  
Quan-xin Ma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Inflammation ◽  
Royal Jelly ◽  
Memory Deficit ◽  
Older Population ◽  
Inflammatory Drug ◽  
Neurodegenerative Dementia ◽  
Anti Inflammatory

Alzheimer’s disease (AD), the most common form of neurodegenerative dementia among the older population, is associated with acute or chronic inflammation. As a nonsteroidal anti-inflammatory drug, aspirin has recently been...

Anti-inflammatory drug studies in Alzheimer's disease

1996 ◽  
Vol 39 (7) ◽  
pp. 563
Author(s):  
P.S. Aisen ◽  
D. Marin ◽  
K.L. Davis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Drug Studies

Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease

2012 ◽  
Vol 8 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Sharlène Côté ◽  
Pierre-Hugues Carmichael ◽  
René Verreault ◽  
Joan Lindsay ◽  
Jean Lefebvre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Drug Use ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Anti-inflammatories in Alzheimer’s disease—potential therapy or spurious correlate?

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Jack Rivers-Auty ◽  
Alison E Mather ◽  
Ruth Peters ◽  
Catherine B Lawrence ◽  
David Brough
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Cognitive Decline ◽  
Negative Binomial ◽  
Drug Efficacy ◽  
Therapeutic Effects ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Epidemiological evidence suggests non-steroidal anti-inflammatory drugs reduce the risk of Alzheimer’s disease. However, clinical trials have found no evidence of non-steroidal anti-inflammatory drug efficacy. This incongruence may be due to the wrong non-steroidal anti-inflammatory drugs being tested in robust clinical trials or the epidemiological findings being caused by confounding factors. Therefore, this study used logistic regression and the innovative approach of negative binomial generalized linear mixed modelling to investigate both prevalence and cognitive decline, respectively, in the Alzheimer’s Disease Neuroimaging dataset for each commonly used non-steroidal anti-inflammatory drug and paracetamol. Use of most non-steroidal anti-inflammatories was associated with reduced Alzheimer’s disease prevalence yet no effect on cognitive decline was observed. Paracetamol had a similar effect on prevalence to these non-steroidal anti-inflammatory drugs suggesting this association is independent of the anti-inflammatory effects and that previous results may be due to spurious associations. Interestingly, diclofenac use was significantly associated with both reduce incidence and slower cognitive decline warranting further research into the potential therapeutic effects of diclofenac in Alzheimer’s disease.

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