Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding

2022 ◽  
Author(s):  
Cheng Fang ◽  
Qingwu Zhou ◽  
Qingyang Liu ◽  
Wei Jia ◽  
Yan Xu
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Alcoholic Beverage ◽  
Alcoholic Liver Injury ◽  
Ethanol Feeding

This study demonstrates that compounds in baijiu, a traditional Chinese alcoholic beverage, can attenuate the development of ethanol-induced liver injury by regulating the crosstalk between gut microbiota and host lipid metabolism.

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

2016 ◽  
Vol 7 (6) ◽  
pp. 2898-2908 ◽  
Author(s):  
Xiaxia Cai ◽  
Lei Bao ◽  
Nan Wang ◽  
Jinwei Ren ◽  
Qihe Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Dietary Nucleotides

The present study aims to investigate whether nucleotides ameliorate alcoholic liver injury and explores the possible mechanism.

Gut dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract against alcohol through the gut–liver axis

2021 ◽  
Author(s):  
Xin Yan ◽  
Yu Wang ◽  
Xue-Yang Ren ◽  
Xiao-Yun Liu ◽  
Jia-Mu Ma ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Gut Dysbiosis ◽  
Hepatoprotective Effects ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract (TQE) against alcoholic liver injury through gut–liver axis modulation.

Fermented ginseng improved alcohol liver injury in association with changes in the gut microbiota of mice

2019 ◽  
Vol 10 (9) ◽  
pp. 5566-5573 ◽  
Author(s):  
Jingjing Fan ◽  
Yushan Wang ◽  
Ying You ◽  
Zhiyi Ai ◽  
Weichang Dai ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Alcoholic Liver Injury ◽  
Fermented Ginseng

Fermented ginseng can alleviate alcoholic liver injury by adjusting the intestinal flora.

scholarly journals Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges

2014 ◽  
Vol 306 (10) ◽  
pp. G819-G823 ◽  
Author(s):  
Stephanie Mathews ◽  
Mingjiang Xu ◽  
Hua Wang ◽  
Adeline Bertola ◽  
Bin Gao
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Neutrophil Infiltration ◽  
Alcoholic Liver Injury ◽  
Drinking Patterns ◽  
Excessive Alcohol Consumption ◽  
Ethanol Feeding ◽  
History Of ◽  
Excessive Alcohol ◽  
Binge Ethanol

Over the last four decades, chronic ethanol feeding studies in rodents using either ad libitum feeding or intragastric infusion models have significantly enhanced our understanding of the pathogenesis of alcoholic liver disease (ALD). Recently, we developed a chronic plus binge alcohol feeding model in mice that is similar to the drinking patterns of many alcoholic hepatitis patients: a history of chronic drinking and recent excessive alcohol consumption. Chronic+binge ethanol feeding synergistically induced steatosis, liver injury, and neutrophil infiltration in mice, which may be useful for the study of early alcoholic liver injury and inflammation. Using this chronic+binge model, researchers have begun to identify novel mechanisms that participate in the pathogenesis of alcoholic liver injury, thereby revealing novel therapeutic targets. In this review article, we briefly discuss several mouse models of ALD with a focus on the chronic+binge ethanol feeding model.

scholarly journals Flavor compounds in fermented Chinese alcoholic beverage alter gut microbiota and attenuate ethanol-induced liver damages

2018 ◽  
Author(s):  
Cheng Fang ◽  
Hai Du ◽  
Zheng Xiaojiao ◽  
Aihua Zhao ◽  
Wei Jia ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Small Molecule ◽  
Relative Abundance ◽  
Alcoholic Beverage ◽  
Intestinal Barrier ◽  
Alcoholic Beverages ◽  
Supporting Evidence ◽  
Pure Ethanol ◽  
Ethanol Feeding ◽  
Fermented Grains

AbstractAlcoholic beverages which are consumed widely in most parts of the world have long been identified as a major risk factor for all liver diseases, particularly alcohol-induced liver disease (ALD). Recent compositional analyses suggest that Chinese Baijiu (CB), a clear alcoholic liquid distilled from fermented grains, contains large amounts of small molecule bioactive compounds in addition to a significant amount of ethanol. Here, in an experimental mouse model, we show that CB caused lower degrees of liver injury than pure ethanol by protecting against the decrease of the relative abundance of Akkermansia and increased relative abundance of Prevotella in the gut thereby preventing the destruction of the intestinal barrier. Furthermore, we demonstrated that ethanol-induced alteration of the gut microbiota profoundly affected the host metabolome. Compared with ethanol feeding, CB feeding resulted in higher concentrations of functional saturated LCFAs and SCFAs. Our results provide supporting evidence that ALD was profoundly influenced by host-gut microbiota metabolic interactions and that small molecule organic compounds in CB could attenuate ALD.

Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury

2012 ◽  
Vol 142 (1) ◽  
pp. 140-151.e12 ◽  
Author(s):  
Tarek Moustafa ◽  
Peter Fickert ◽  
Christoph Magnes ◽  
Christian Guelly ◽  
Andrea Thueringer ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Cholestatic Liver Injury ◽  
Mediate Inflammation

scholarly journals Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism

2021 ◽  
Vol 134 ◽  
pp. 111121
Author(s):  
Yu-Shi Liu ◽  
Ming-Hao Yuan ◽  
Cun-Yan Zhang ◽  
Hong-Mei Liu ◽  
Juan-Ru Liu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Alcoholic Liver Injury
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