scholarly journals Advanced Continuous-Flow Microfluidic Device for Parallel Screening of Crystal Polymorphs, Morphology and Kinetics at Controlled Supersaturation

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Paria Coliaie ◽  
Manish S Kelkar ◽  
Marianne Langston ◽  
Chengxiang Liu ◽  
Neda Nazemifard ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Combinatorial Screening ◽  
Crystalline Materials ◽  
Pharmaceutical Ingredients ◽  
Parallel Screening

A flow-controlled microfluidic device for parallel and combinatorial screening of crystalline materials can profoundly impact the discovery and development of active pharmaceutical ingredients and other crystalline materials. While the existing...

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

Continuous-flow, well-mixed, microfluidic crystallization device for screening of polymorphs, morphology, and crystallization kinetics at controlled supersaturation

Lab on a Chip ◽  
2019 ◽  
Vol 19 (14) ◽  
pp. 2373-2382 ◽  
Author(s):  
Paria Coliaie ◽  
Manish S. Kelkar ◽  
Nandkishor K. Nere ◽  
Meenesh R. Singh
Keyword(s):  
Crystallization Kinetics ◽  
Microfluidic Device ◽  
Continuous Flow ◽  
Crystalline Materials ◽  
Screening Techniques

While the conventional screening techniques suffer from depletion of supersaturation, the continuous-flow microfluidic device screens crystalline materials at controlled supersaturation.

scholarly journals Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

2020 ◽  
Vol 5 (7) ◽  
pp. 1186-1197 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Mathilde A. C. H. Janssen ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Flow Processes ◽  
Selection Of

This review highlights a selection of multistep continuous flow (one-flow) processes leading to the synthesis of active pharmaceutical ingredients (APIs).

Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

2020 ◽  
Vol 5 (9) ◽  
pp. 1527-1555 ◽  
Author(s):  
Zsolt Fülöp ◽  
Péter Szemesi ◽  
Péter Bana ◽  
János Éles ◽  
István Greiner
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Design Strategies ◽  
Flow Synthesis ◽  
Pharmaceutical Ingredients ◽  
Continuous Preparation

This review focuses on the flow-oriented design (FOD) in the multi-step continuous-flow synthesis of active pharmaceutical ingredients.

Continuous flow upgrading of glycerol toward oxiranes and active pharmaceutical ingredients thereof

2019 ◽  
Vol 21 (16) ◽  
pp. 4422-4433 ◽  
Author(s):  
Romain Morodo ◽  
Romaric Gérardy ◽  
Guillaume Petit ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Amino Alcohol ◽  
Continuous Flow ◽  
Value Added ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

A robust continuous flow procedure for the transformation of bio-based glycerol into high value-added β-amino alcohol active pharmaceutical ingredients.

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

2019 ◽  
Vol 17 (6) ◽  
pp. 1552-1557 ◽  
Author(s):  
Renata M. Aguiar ◽  
Raquel A. C. Leão ◽  
Alejandro Mata ◽  
David Cantillo ◽  
C. Oliver Kappe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Continuous Flow ◽  
Building Blocks ◽  
Active Pharmaceutical Ingredients ◽  
Enantiomerically Pure ◽  
Pharmaceutical Ingredients ◽  
Chiral Intermediates

Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building blocks.

Selectivity engineering of the diazotization reaction in a continuous flow reactor

2016 ◽  
Vol 1 (4) ◽  
pp. 387-396 ◽  
Author(s):  
C. A. Shukla ◽  
A. A. Kulkarni ◽  
V. V. Ranade
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Diazonium Salts ◽  
Fine Chemicals ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Reactor

In situ generated diazonium salts are useful intermediates for the synthesis of fine chemicals and active pharmaceutical ingredients. This paper presents a methodology for selectivity engineering of the diazotization reaction in continuous reactors.

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