Early Biomineralizing Chitosan-Collagen Hybrid Scaffold with Cissus quadrangularis Extract for Regenerative Bone Tissue Engineering

2021 ◽  
Author(s):  
Praseetha R Nair ◽  
Sreeja S ◽  
G.S. Sailaja
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Stability ◽  
Hexane Extract ◽  
Hybrid Scaffold ◽  
Biodegradable Scaffold ◽  
Cissus Quadrangularis ◽  
Porous Chitosan ◽  
Cross Linker

This study demonstrates the strategic fabrication of Cissus quadrangularis (CQ) hexane extract integrated porous chitosan-collagen (CH-CO-HE) biodegradable scaffold crosslinked with glyoxal, a biocompatible cross-linker, that enables sufficient mechanical stability and...

scholarly journals Preparation and biological properties of silk fibroin/nano-hydroxyapatite/graphene oxide scaffolds with an oriented channel-like structure

RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 10118-10128 ◽  
Author(s):  
Lu Wang ◽  
Min Fang ◽  
Yijing Xia ◽  
Jiaxin Hou ◽  
Xiaoru Nan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Biological Properties ◽  
Hybrid Scaffold

A novel SF/nHAp/GO hybrid scaffold with oriented channel-like structure in bone tissue engineering.

Bio-inspired hybrid scaffold of zinc oxide-functionalized multi-wall carbon nanotubes reinforced polyurethane nanofibers for bone tissue engineering

2017 ◽  
Vol 133 ◽  
pp. 69-81 ◽  
Author(s):  
Bishnu Kumar Shrestha ◽  
Sita Shrestha ◽  
Arjun Prasad Tiwari ◽  
Jeong-In Kim ◽  
Sung Won Ko ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Zinc Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Scaffold ◽  
Multi Wall Carbon Nanotubes

scholarly journals An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jozafina Haj ◽  
Tharwat Haj Khalil ◽  
Mizied Falah ◽  
Eyal Zussman ◽  
Samer Srouji
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Dorsal Side ◽  
Human Mscs ◽  
Hybrid Scaffold

While biologically feasible, bone repair is often inadequate, particularly in cases of large defects. The search for effective bone regeneration strategies has led to the emergence of bone tissue engineering (TE) techniques. When integrating electrospinning techniques, scaffolds featuring randomly oriented or aligned fibers, characteristic of the extracellular matrix (ECM), can be fabricated. In parallel, mesenchymal stem cells (MSCs), which are capable of both self-renewing and differentiating into numerous tissue types, have been suggested to be a suitable option for cell-based tissue engineering therapies. This work aimed to create a novel biocompatible hybrid scaffold composed of electrospun polymeric nanofibers combined with osteoconductive ceramics, loaded with human MSCs, to yield a tissue-like construct to promote in vivo bone formation. Characterization of the cell-embedded scaffolds demonstrated their resemblance to bone tissue extracellular matrix, on both micro- and nanoscales and MSC viability and integration within the electrospun nanofibers. Subcutaneous implantation of the cell-embedded scaffolds in the dorsal side of mice led to new bone, muscle, adipose, and connective tissue formation within 8 weeks. This hybrid scaffold may represent a step forward in the pursuit of advanced bone tissue engineering scaffolds.

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