Effect of Anatomical Sites On the Mechanical Properties of Spinal Dura Subjected to Biaxial Stretching

The spinal cord is encased by spinal meninges called the pia, arachnoid, and dura maters. Among these membranes, the dura mater is the thick and outermost layer and is the toughest and strongest. Thus, mechanical failure of the dura mater can lead to spontaneous cerebrospinal fluid leaks or hypovolemia, resulting in a complication or exacerbation of unfavorable symptoms involved in a mild traumatic brain injury. To develop protective equipment that can help prevent such injuries, accurate characterization of the spinal dura mater is required, especially regarding the mechanical properties at different anatomical sites. In this study, we used an equiload biaxial tensile tester to investigate the mechanical properties of porcine meningeal dura mater along the whole length of the spine. The resultant strain of the dorsal side was greater than that of the ventral side (P < 0.01), while the circumferential direction was significantly stiffer than the longitudinal direction (P < 0.01) at lower strains regardless of the spinal level. We also found that the material stiffness progressively increased from the cervical level to the thoracolumbar level at lower strains, which implies that the dura mater inherently possesses structurally preferred features or functions because the neck requires sufficient flexibility for daily activities. Further, Young's modulus was significantly less on the dorsal side than on the ventral side at higher strains (P < 0.05), suggesting that the dorsal side is readily elongated by spinal flexion even within the range of physiological motion.

Patterns of Seed Penetration by the Date Stone Beetle Coccotrypes dactyliperda (Coleoptera, Curculionidae, Scolytinae)

The cryptic spermatophagus date stone beetle (Coccotrypes dactyliperda Fabricius, 1801) tunnels into palm seeds for oviposition and subsequent establishment of brood galleries. Based on behavioral observations this paper describes the biomechanical and gustatory parameters that govern the initial excavation of the tunnels and the subsequent establishment of the galleries. When tunneling into Canary Islands Date Palm (Phoenix canariensis Chabaud, 1882) seeds, penetration principally occurs at the dorsal side of the seed, in particular the groove, which allows the beetle to gain the required traction. Tunneling is executed in a circular fashion with clockwise or counter-clockwise repositioning in approximately one-eighth to one-quarter turns. Biomechanically, the three pairs of legs provide thrust (hind legs), pivoting (mid legs), and lateral control (fore legs). Gustatory cues, the nature of which remains unclear at this point, prevent the beetle from tunneling through to the other side.

Level of Sagittal Plane Fit of Plates on the Radial Shaft: A Cadaveric Study Comparing Precontoured and Straight Titanium Plates

Background: During radial shaft fracture fixation, it is important to contour the plate appropriately to restore the radial bow in order to maintain normal forearm mechanics and motion. The aim of this study was to investigate the fit of precontoured radial shaft plates versus surgeon-contoured plates. Methods: Six 10-hole Acumed® precontoured volar and dorsolateral radius plates and twelve 10-hole Synthes straight titanium 3.5 mm LC-DCP plates were drilled with arrays of 1.5 mm diameter holes to permit measurement of the plate distance off bone. Plates were applied to 6 cadaver radii and secured with a screw on each end. Three plate conditions were tested: precontoured plates, precontoured plates with further surgeon contouring, and straight plates with surgeon contouring. Surgeon contouring time for each plate was recorded. Each plate was divided into 3 equal regions, and the average distance gaps for each region and the entire plate were calculated. Results: For the volar side, precontoured plates had a larger total gap compared to that plate with additional surgeon contouring (1.4 mm difference) and the straight surgeon-contoured plates (1.2 mm difference). On the dorsal side, there was no difference in fit between the 3 plate conditions at any location. No differences were found in plate contouring times. Conclusions: The precontoured dorsal plate fit was as good as the surgeon-contoured plates indicating this plate could potentially be used in fracture surgery without further bending. The precontoured volar plate was under-contoured, on average, and would likely require further bending to restore the radial bow.

Blister-like aneurysm of the anterior communicating artery treated with only Low-profile Visualized Intraluminal Support Junior stent

Background: Endovascular treatment is becoming a mainstream treatment for blister-like aneurysms in recent years. Blister-like aneurysms are usually located in the internal carotid artery, whereas that of the anterior communicating artery (AcomA) are very rare. We report the first case of blister-like aneurysm of AcomA that was treated solely with a neck bridging stent that resulted in complete occlusion without complication. Case Description: A 50- year- old woman was admitted to our hospital due to a subarachnoid hemorrhage. Digital subtraction angiography showed a very small aneurysm in the dorsal side of the AcomA. We considered it a blister-like aneurysm based on its size and shape. She underwent endovascular treatment under general anesthesia on day 15 after vasospasm period. Dual antiplatelet therapy was administrated 1 week prior. A Low-profile Visualized Intraluminal Support Junior stent was implanted from the left A2 to the right A1, covering the AcomA. The postoperative course was uneventful, and she was discharged with no neurological deficit. The aneurysm remained unchanged on postoperative day 14; however, complete occlusion was achieved 3 months after the treatment. Conclusion: Monotherapy with a neck bridging stent is an effective treatment option for blister-like aneurysms. Treatment with a single stent could achieve complete occlusion especially if the aneurysms occur elsewhere than the internal carotid artery. We should consider immediate additional treatment if the aneurysm grows within 1 month after initial treatment.

Contact Force Measurement Approach for Measuring Glove-Skin Interfacial Pressure

Pressure garments for medical had been widely used to enhance the recovery after an operation, for treatment of arthritis, deep vein thrombosis, leg ulcers, varicose veins or hypertrophic scars. This research aims to develop a contact force measuring approach to measure glove-skin interfacial pressure. With the aid of a force measuring sensors system, it is easier to study the efficiency of pressure garments. Besides, occupational therapists can also design a user-friendly pressure garment that is comfortable and easy to donning and doffing, especially for children. Two types of flexible force sensors were used to measure the glove-skin interfacial pressure using two types of pressure therapy gloves. Pressure therapy glove is selected to represent pressure garments. The measuring sensors were placed at three different locations on the dorsal side of the hand, and the glove-skin interfacial pressure was measured in two different postures, which is full fist and tabletop posture. It was found that different postures had led to different interfacial pressure. The glove-skin interfacial pressure was found to be greater during full fist posture compared to tabletop posture. This show that the applied glove-skin interfacial pressure is affected by postures and movement.

Lithobius (Monotarsobius) tetrasulcus sp. n., a new species of centipede from China (Lithobiomorpha, Lithobiidae)

The myriapod fauna of China is still poorly known and very little attention has been paid to the study of Lithobiomorpha, with only 100 species and subspecies known from the country. Altogether, 11 species of subgenus Monotarsobius have been recorded from China, but only two of them have been reported from Hebei Province. Herein, a new species recently discovered in the Hebei Province, China, is described and illustrated. A new lithobiids species Lithobius (Monotarsobius) tetrasulcus sp. n. is described and illustrated from Hengshui Lake National Nature Reserve, Hebei Province, China. The new species is compared with Lithobius (Monotarsobius) crassipes Koch, 1862 from Taiwan, China. It can be easily distinguished from congeners by having a longitudinal groove on the dorsal side of the femur and tibia of the male legs 14 and 15, only having a posterior spine on the dorsal side of femur of legs 12–15, lacking robust spines lying dorsally on the external margin on the second article of the female gonopods and the third article of the female gonopods having a bidentate apical claw.

Origin of the Chordate Notochord

The phylum of Chordata is defined based on the discovery of a coelom-like dorsal notochord in ascidian and amphioxus embryos. Chordata can be classified into three subphylums, Cephalochordata, Urochordata, and Vertebrata, united by the presence of a notochord at some point during development. The origin of the notochord, the signature anatomical structure of chordates, has been under debate since the publication of Alexander Kovalevsky’s work in the mid-19th century that placed ascidians close to the vertebrates on the phylogenetic tree. During the late 20th century, the development of molecular and genetic tools in biology brought about a revival of studies on the evolutionary path of notochord development. Two main hypotheses for the origin of the notochord were proposed, the de novo theory and the axochord theory. The former states that notochord has developed de novo from the mid-dorsal archenteron of a chordate ancestor with simple morphology and no central nervous system nor notochord homolog. The putative notochord along the dorsal side of the animal is proposed to take on the signal functions later from the endoderm and ectoderm. An alternative hypothesis, the axochord theory, proposes that notochord has evolved from the mid-line muscle tissue, the so-called axochord, in annelids. Structural and molecular evidence point to the midline muscle of annelids as a distant homolog of the notochord. This hypothesis thus suggests a notochord-like structure in the urbilaterian ancestor, opposed to the consensus that notochord is a chordate-specific feature. In this review, we introduce the history of the formation of these views and summarize the current understandings of embryonic development, molecular profile, and gene regulatory networks of notochord and notochord-like structures.

Left paraduodenal hernia treated by single-incision laparoscopic surgery: a case report

Background Paraduodenal hernia is a rare internal hernia which accounts for only 1% of all intestinal hernias. There have been limited reported cases of paraduodenal hernia treated by laparoscopic surgery. We report a case of left paraduodenal hernia that was successfully treated by single-incision laparoscopic surgery (SILS). Case presentation A 17-year-old woman presented with left upper abdominal pain. An abdominal enhanced multi-detector computed tomography demonstrated encapsulated cluster of small bowel loops in the left upper quadrant which passed through the dorsal side of the inferior mesenteric vein, and showed that blood flow of the prolapsed small bowel was preserved. We preoperatively diagnosed left paraduodenal hernia without ischemia or necrosis. We performed elective SILS because she was a young actress training school student and cosmetic benefit was thought to be important. We pulled out the protruded small bowel and closed a defect with a running suture by SILS. The patient was discharged 3 days after the surgery with no complications. Conclusions We reported the case of left paraduodenal hernia successfully diagnosed and treated by SILS.

Transmembrane H+ fluxes and the regulation of neural induction in Xenopus laevis

Summary It has previously been reported that in ex vivo planar explants prepared from Xenopus laevis embryos, the intracellular pH (pHi) increases in cells of the dorsal ectoderm from stage 10.5 to 11.5 (i.e. 11–12.5 hpf). It was proposed that such increases (potentially due to H+ being extruded, sequestered, or buffered in some manner), play a role in regulating neural induction. Here, we used an extracellular ion-selective electrode to non-invasively measure H+ fluxes at eight locations around the equatorial circumference of intact X. laevis embryos between stages 9–12 (˜7–13.25 hpf). We showed that at stages 9–11, there was a small H+ efflux recorded from all the measuring positions. At stage 12 there was a small, but significant, increase in the efflux of H+ from most locations, but the efflux from the dorsal side of the embryo was significantly greater than from the other positions. Embryos were also treated from stages 9–12 with bafilomycin A1, to block the activity of the ATP-driven H+ pump. By stage 22 (24 hpf), these embryos displayed retarded development, arresting before the end of gastrulation and therefore did not display the usual anterior and neural structures, which were observed in the solvent-control embryos. In addition, expression of the early neural gene, Zic3, was absent in treated embryos compared with the solvent controls. Together, our new in vivo data corroborated and extended the earlier explant-derived report describing changes in pHi that were suggested to play a role during neural induction in X. laevis embryos.

Design and Performance Evaluation of a Hybrid Hand Exoskeleton for Hand Opening/Closing

Finger extensor muscle weakness and flexor hypertonia are the most commonly reported issues among patients suffering from amyotrophic lateral sclerosis (ALS). Moreover, the relative hyperflexion of the wrist and the fingers has limited their ability to open the hand and interact with the external environment voluntarily. In this work, a hybrid hand exoskeleton is developed to prevent the relative hyperflexion of the fingers and wrist and facilitate the users in their functional hand opening by compensating the flexor hypertonia. This exoskeleton, combining a passive device with the soft extra muscle (SEM) glove, assists users in normal hand opening/closing required for some basic activities of daily living. The paper presents kinematic and static models of passive hand exoskeleton design. Moreover, the proposed design is tested and evaluated by comparing the volunteer hand opening with the exoskeleton assistance using the flex sensors attached on the dorsal side of the middle finger, ring finger, and thumb with both healthy subjects and patients.