One-pot synthesis of high-concentration mixed-shell polymeric micelles as nanochaperones for renaturation of bulk proteins

2021 ◽  
Author(s):  
Fei Deng ◽  
Menglin Yang ◽  
Yanli Zhang ◽  
Xiaohui Wu ◽  
Rujiang Ma ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
The Self ◽  
High Concentration ◽  
One Pot ◽  
Native Form ◽  
Denatured Protein ◽  
One Pot Synthesis ◽  
Self Assembled ◽  
And Storage

Refolding denatured protein into its native form and stabilizing its structure are significant in the production and storage of protein products. The self-assembled mixed-shell polymeric micelle (MSPM) based nanochaperone closely...

scholarly journals Facile One-Pot Synthesis of Self-Assembled Folate-Biotin-Pullulan Nanoparticles for Targeted Intracellular Anticancer Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ming Wang ◽  
Meiling Huang ◽  
Jianting Wang ◽  
Mingquan Ye ◽  
Yan Deng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Folate Receptor ◽  
Flow Cytometric Analysis ◽  
Laser Scanning Microscopy ◽  
The Self ◽  
Kb Cells ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

The self-assembled folate-biotin-pullulan (FBP) nanoparticles (NPs) were prepared by facile one-pot synthesis and their physicochemical properties were characterized. The self-assembled FBP NPs were used as an anticancer drug nanocarrier entrapping doxorubicin (DOX) for targeting folate-receptors-overexpressing cancer cells. The identification of prepared NPs to folate-receptor-expressing cancer cells (KB cells) was affirmed by cell viability measurement, folate competition test, and flow cytometric analysis. Compared with the naked DOX and DOX/BP NPs, the DOX/FBP NPs had lower IC50value compared to KB cells as a result of the folate-receptor-mediated endocytosis process. The cytotoxicity of DOX/FBP NPs to KB cells could be inhibited competitively by free folate. The cellular intake pattern of naked DOX and drug-loaded NPs was identified by confocal laser scanning microscopy (CLSM) observation and the higher cellular uptake of drug for DOX/FBP NPs over naked DOX was observed. The prepared FBP NPs had the potential to be used as a powerful carrier to target anticancer drugs to folate-receptor-expressing tumor cells and reduce cytotoxicity to normal tissues.

Self assembled homodinuclear dithiocarbamates: One pot synthesis and spectral characterization

2014 ◽  
Vol 118 ◽  
pp. 380-388 ◽  
Author(s):  
Shahab A.A. Nami ◽  
Ahmad Husain ◽  
Irfan Ullah
Keyword(s):  
Spectral Characterization ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

Self-assembled one-pot synthesis of red luminescent CdS:Mn/Mn(OH)2 nanoparticles

2008 ◽  
Vol 128 (12) ◽  
pp. 1980-1984 ◽  
Author(s):  
M. Marandi ◽  
N. Taghavinia ◽  
A. Iraji zad ◽  
S.M. Mahdavi
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

One-pot synthesis of self-assembled heteroleptic palladium(II) complexes with tmeda: An application of ligand exchange reactions

2014 ◽  
Vol 39 ◽  
pp. 75-78 ◽  
Author(s):  
Sreenivasulu Bandi ◽  
Niladri Bihari Debata ◽  
Venkatachalam Ramkumar ◽  
Dillip Kumar Chand
Keyword(s):  
Ligand Exchange ◽  
Exchange Reactions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

One pot synthesis of self-assembled V2O5 nanobelt membrane via capsule-like hydrated precursor as improved cathode for Li-ion battery

2011 ◽  
Vol 21 (28) ◽  
pp. 10336 ◽  
Author(s):  
Yu Wang ◽  
Hui Juan Zhang ◽  
Kien Wei Siah ◽  
Chee Cheong Wong ◽  
Jianyi Lin ◽  
...  
Keyword(s):  
Li Ion Battery ◽  
One Pot ◽  
One Pot Synthesis ◽  
Li Ion ◽  
Self Assembled

scholarly journals Green Efficient One-Pot Synthesis and Separation of Nitrones in Water Assisted by a Self-Assembled Nanoreactor

2021 ◽  
Vol 23 (1) ◽  
pp. 236
Author(s):  
Vincenzo Patamia ◽  
Giuseppe Floresta ◽  
Venerando Pistarà ◽  
Antonio Rescifina
Keyword(s):  
Supramolecular Chemistry ◽  
Reaction Times ◽  
Synthesis Methods ◽  
One Pot ◽  
Hydrophobic Cavity ◽  
One Pot Synthesis ◽  
Alternative Method ◽  
Self Assembled

This article reports an alternative method for preparing nitrones using a tetrahedral capsule as a nanoreactor in water. Using the hydrophobic cavity of the capsule allowed us to reduce the reaction times and easily separate the nitrones from the reaction mixture, obtaining reaction yields equal or comparable to those obtained with the methods already reported. Furthermore, at the basis of this methodology, there is an eco-friendly approach carried out that can certainly be extended to other synthesis methods for the preparation of other substrates by exploiting various types of macrocyclic hosts, suitably designed and widely used in supramolecular chemistry.

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