scholarly journals Green Efficient One-Pot Synthesis and Separation of Nitrones in Water Assisted by a Self-Assembled Nanoreactor

2021 ◽  
Vol 23 (1) ◽  
pp. 236
Author(s):  
Vincenzo Patamia ◽  
Giuseppe Floresta ◽  
Venerando Pistarà ◽  
Antonio Rescifina
Keyword(s):  
Supramolecular Chemistry ◽  
Reaction Times ◽  
Synthesis Methods ◽  
One Pot ◽  
Hydrophobic Cavity ◽  
One Pot Synthesis ◽  
Alternative Method ◽  
Self Assembled

This article reports an alternative method for preparing nitrones using a tetrahedral capsule as a nanoreactor in water. Using the hydrophobic cavity of the capsule allowed us to reduce the reaction times and easily separate the nitrones from the reaction mixture, obtaining reaction yields equal or comparable to those obtained with the methods already reported. Furthermore, at the basis of this methodology, there is an eco-friendly approach carried out that can certainly be extended to other synthesis methods for the preparation of other substrates by exploiting various types of macrocyclic hosts, suitably designed and widely used in supramolecular chemistry.

scholarly journals Synthesis of 2,4,6-triarylpyridines Using AlPO4 Under Solvent-free Conditions

2010 ◽  
Vol 2 (2) ◽  
pp. 337-342 ◽  
Author(s):  
P. Rajput ◽  
N. J. P. Subhashini ◽  
Shiva Raj
Keyword(s):  
Heterogeneous Catalyst ◽  
Simple Procedure ◽  
Reaction Times ◽  
Aluminum Phosphate ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

A series of 2,4,6-triarylpyridines have been prepared using a variety of aromatic and heteroaromatic aldehydes in the presence of aluminum phosphate (AlPO4) as a heterogeneous catalyst at 120 oC under solvent-free conditions. The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times, milder conditions and the catalyst exhibited remarkable reusable activity. Keywords: Aluminum phosphate; 2,4,6-triarylpyridines; One-pot synthesis; Shorter reaction times;  Reusable activity.  © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i2.3859               J. Sci. Res. 2 (2), 337-342 (2010) 

One-Pot Synthesis of α-Amino Acids from Imines through CO2 Incorporation: An Alternative Method for Strecker Synthesis

2011 ◽  
Vol 123 (6) ◽  
pp. 1429-1432 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Jianyang Chen ◽  
Masumi Sugawara ◽  
Yoshihiro Sato
Keyword(s):  
Amino Acids ◽  
One Pot ◽  
One Pot Synthesis ◽  
Alternative Method ◽  
Strecker Synthesis

scholarly journals One-Pot Synthesis of α-Substituted Acrylates

SynOpen ◽  
2018 ◽  
Vol 02 (02) ◽  
pp. 0161-0167
Author(s):  
Magdalini Matziari ◽  
Yixin Xie
Keyword(s):  
Amino Acids ◽  
Reaction Times ◽  
Synthetic Method ◽  
One Pot ◽  
Biologically Relevant ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Acrylic Esters ◽  
Natural Amino Acids ◽  
Work Up

A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner–Wadsworth–Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

scholarly journals The Role Ionic Liquid [BMIM][PF6] in One-Pot Synthesis of Tetrahydropyran Rings through Tandem Barbier–Prins Reaction

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2084
Author(s):  
Poliane K. Batista ◽  
João Marcos G. de O. Ferreira ◽  
Fabio P. L. Silva ◽  
Mario L. A. A Vasconcellos ◽  
Juliana A. Vale
Keyword(s):  
Ionic Liquid ◽  
Yield Loss ◽  
Allyl Bromide ◽  
Reaction Times ◽  
Prins Reaction ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Barbier Reaction ◽  
Significant Yield

Tetrahydropyran (THP) rings are common in several natural products, therefore, various strategies are being developed to synthesize these rings. The present work described the study of a one-pot synthesis of 2,4,6-trisubstituted tetrahydropyran compounds promoted by the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] through a Barbier–Prins reaction between allyl bromide and aldehydes. The use of [BMIM][PF6] gave Prins products from several aldehydes in good yields and reaction times. We also found that the anion, PF6-, accelerates the Barbier reaction when used alone, and the excess SnBr2 from the reaction conditions of the Barbier reaction leads to the formation of the THP rings, thus acting as a catalyst for Prins cyclization. Additionally, we demonstrate that ionic liquid can be recovered and reused five times in the preparation of 4-bromo-tetrahydro-2,6-diphenyl-2H-pyran without significant yield loss.

An efficient synthesis of phenyl-substituted dibenzonaphthyridines

2009 ◽  
Vol 2009 (8) ◽  
pp. 485-488 ◽  
Author(s):  
Manickam Manoj ◽  
Karnam Jayaramapillai Rajendra Prasad
Keyword(s):  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Alternative Method

A one-pot synthesis of 9-chloro-6-methyl-7-phenyldibenzo[ b,h][1,6]naphthyridines from 4-chloro-2-methylquinolines is reported. Since the yield of the dibenzonaphthyridine was low, in an alternative method the title compounds were prepared from the 4-chloro-2-methylquinolines via 2-methyl-4-[(4-chlorophenyl)amino]quinolines as intermediates, which provided improved yields.

Self-assembled one-pot synthesis of red luminescent CdS:Mn/Mn(OH)2 nanoparticles

2008 ◽  
Vol 128 (12) ◽  
pp. 1980-1984 ◽  
Author(s):  
M. Marandi ◽  
N. Taghavinia ◽  
A. Iraji zad ◽  
S.M. Mahdavi
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

scholarly journals Facile One-Pot Synthesis of Self-Assembled Folate-Biotin-Pullulan Nanoparticles for Targeted Intracellular Anticancer Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ming Wang ◽  
Meiling Huang ◽  
Jianting Wang ◽  
Mingquan Ye ◽  
Yan Deng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Folate Receptor ◽  
Flow Cytometric Analysis ◽  
Laser Scanning Microscopy ◽  
The Self ◽  
Kb Cells ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

The self-assembled folate-biotin-pullulan (FBP) nanoparticles (NPs) were prepared by facile one-pot synthesis and their physicochemical properties were characterized. The self-assembled FBP NPs were used as an anticancer drug nanocarrier entrapping doxorubicin (DOX) for targeting folate-receptors-overexpressing cancer cells. The identification of prepared NPs to folate-receptor-expressing cancer cells (KB cells) was affirmed by cell viability measurement, folate competition test, and flow cytometric analysis. Compared with the naked DOX and DOX/BP NPs, the DOX/FBP NPs had lower IC50value compared to KB cells as a result of the folate-receptor-mediated endocytosis process. The cytotoxicity of DOX/FBP NPs to KB cells could be inhibited competitively by free folate. The cellular intake pattern of naked DOX and drug-loaded NPs was identified by confocal laser scanning microscopy (CLSM) observation and the higher cellular uptake of drug for DOX/FBP NPs over naked DOX was observed. The prepared FBP NPs had the potential to be used as a powerful carrier to target anticancer drugs to folate-receptor-expressing tumor cells and reduce cytotoxicity to normal tissues.

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