Euphorstranoids A and B, Two Highly Rearranged Ingenane Diterpenoids from Euphorbia stracheyi: Structural Elucidation, Chemical Transformation, and Lipid-Lowering Activity

2022 ◽  
Author(s):  
Fang-Yu Yuan ◽  
Yue-Hua Pan ◽  
Ai-Ping Yin ◽  
Wei Li ◽  
Dong Huang ◽  
...  
Keyword(s):  
Chemical Transformation ◽  
Ring System ◽  
Structural Elucidation ◽  
Lipid Lowering ◽  
Carbon Ring ◽  
Lowering Activity

Euphorstranoids A (1) and B (2), two highly rearranged ingenane diterpenoids with an unusual 5/6/7/3 carbon ring system, were isolated from Euphorbia stracheyi. Their structures were determined by a combination...

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia

2006 ◽  
Vol 105 (3) ◽  
pp. 332-335 ◽  
Author(s):  
C. Santhosh Kumari ◽  
S. Govindasamy ◽  
E. Sukumar
Keyword(s):  
Lipid Lowering ◽  
Eclipta Prostrata ◽  
Experimental Hyperlipidemia ◽  
Lowering Activity

Access to the Bicyclo[5.3.1]undecadiene Ring System by Two Carbon Ring Enlargement of Bicyclo[3.3.1]nonane Derivatives

Synlett ◽  
1996 ◽  
Vol 1996 (04) ◽  
pp. 385-386 ◽  
Author(s):  
Michel Miesch ◽  
Gaëtan Mislin ◽  
Michel Franck-Neumann
Keyword(s):  
Ring System ◽  
Ring Enlargement ◽  
Carbon Ring

Design of a pharmaceutical composition with a low-dose statin and a high lipid-lowering activity

2021 ◽  
Vol 70 (1) ◽  
pp. 52-56
Author(s):  
Natalia Dmitrievna Bunyatyan ◽  
Anastasia Evgen'evna Kozlova ◽  
Vladimir Pavlovich Balashov ◽  
Alexey Vladimirovich Balashov ◽  
Ruslan Evgenievich Kazakov ◽  
...  
Keyword(s):  
Low Dose ◽  
Lipid Lowering ◽  
High Lipid ◽  
Pharmaceutical Composition ◽  
Lowering Activity

scholarly journals Lipid Lowering Activity and Free Radical Scavenging Effect of Cinnamomum tamala (Fam: Lauraceae)

1970 ◽  
Vol 1 (4) ◽  
pp. 93-96
Author(s):  
R Al-Mamun ◽  
A Hamid ◽  
MK Islam ◽  
JA Chowdhury ◽  
ATM Zafrul Azam
Keyword(s):  
Free Radical ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Free Radical Scavenging ◽  
Lipid Lowering ◽  
Increased Risk ◽  
Lowering Activity

Lipid profile is a blood test that measures the amount of lipids, or fats, in your blood. The lipids measured are usually total cholesterol, HDL-C, LDL-C and triglycerides. When levels of these lipids are abnormal, there is an increased risk of heart attack and stroke. In our study, we use methanol crude extract for lipid lowering activity on rabbit and found that lipid profile was reduced by 14.0, 1.0, 4.0 and 15.0 mg/dl for total cholesterol, HDL-C, LDL-C and triglyceride respectively after using the plant extract (dose 500mg/rabbit for 10 days); where atorvastatin (0.005mg/rabbit) was used as standard lipid lowering agent. We also focused on the antioxidant property of crude methanol extract. Here we also carried out free radical-scavenging activity study and found the IC50 value for C. tamala is 6.00 μg/ml where the standard antioxidant (ascorbic acid) gave the value of 3.21μg/ml. DOI: http://dx.doi.org/10.3329/ijns.v1i4.9735 IJNS 2011 1(4): 93-96

A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering Activity

1999 ◽  
Vol 42 (19) ◽  
pp. 3785-3788 ◽  
Author(s):  
Peter J. Brown ◽  
Deborah A. Winegar ◽  
Kelli D. Plunket ◽  
Linda B. Moore ◽  
Michael C. Lewis ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Subtype Selective ◽  
Lowering Activity ◽  
Pparα Agonist
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