scholarly journals Glass surface as strong base, ‘green’ heterogeneous catalyst and degradation reagent

2021 ◽  
Author(s):  
Yangjie Li ◽  
Kai-Hung Huang ◽  
Nicolás M. Morato ◽  
R. Graham Cooks
Keyword(s):  
Mass Spectrometry ◽  
Solid Solution ◽  
Electrospray Ionization ◽  
Chemical Reactions ◽  
High Throughput ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass ◽  
Systematic Screening ◽  
Strong Base ◽  
Glass Surfaces

Systematic screening of accelerated chemical reactions at solid/solution interfaces has been carried out in high-throughput fashion using desorption electrospray ionization mass spectrometry and it provides evidence that glass surfaces accelerate...

scholarly journals Glass Surface as Strong Base, ‘Green’ Heterogeneous Catalyst and Degradation Reagent

2021 ◽  
Author(s):  
Yangjie Li ◽  
Kai-Hung Huang ◽  
Nicolás Morato ◽  
R. Graham Cooks
Keyword(s):  
Chemical Reactions ◽  
Heterogeneous Catalysts ◽  
Desorption Electrospray Ionization ◽  
Mechanistic Study ◽  
Ionization Mass ◽  
Systematic Screening ◽  
Strong Base ◽  
Low Concentrations ◽  
Conjugate Bases ◽  
Glass Surfaces

Systematic screening of accelerated chemical reactions at solid/solution interfaces has been carried out in high-throughput fashion using desorption electrospray ionization mass spectrometry and it provides evidence that glass surfaces accelerate various base-catalyzed chemical reactions. The reaction types include elimination, solvolysis, condensation and oxidation, whether or not the substrates are pre-charged. In a detailed mechanistic study, we provide evidence using nanoESI showing that glass surfaces can act as strong bases and convert protic solvents into their conjugate bases which then act as bases/nucleophiles when participating in chemical reactions. In aprotic solvents such as acetonitrile, glass surfaces act as ‘green’ heterogeneous catalysts that can be recovered and reused after simple rinsing. Besides their use in organic reaction catalysis, glass surfaces are also found to act as degradation reagents for phospholipids with increasing extents of degradation occuring at low concentrations. This finding suggests that the storage of base/nucleophile-labile compounds or lipids in glass containers should be avoided. <br>

scholarly journals Glass Surface as Strong Base, ‘Green’ Heterogeneous Catalyst and Degradation Reagent

2021 ◽  
Author(s):  
Yangjie Li ◽  
Kai-Hung Huang ◽  
Nicolás Morato ◽  
R. Graham Cooks
Keyword(s):  
Chemical Reactions ◽  
Heterogeneous Catalysts ◽  
Desorption Electrospray Ionization ◽  
Mechanistic Study ◽  
Ionization Mass ◽  
Systematic Screening ◽  
Strong Base ◽  
Low Concentrations ◽  
Conjugate Bases ◽  
Glass Surfaces

Systematic screening of accelerated chemical reactions at solid/solution interfaces has been carried out in high-throughput fashion using desorption electrospray ionization mass spectrometry and it provides evidence that glass surfaces accelerate various base-catalyzed chemical reactions. The reaction types include elimination, solvolysis, condensation and oxidation, whether or not the substrates are pre-charged. In a detailed mechanistic study, we provide evidence using nanoESI showing that glass surfaces can act as strong bases and convert protic solvents into their conjugate bases which then act as bases/nucleophiles when participating in chemical reactions. In aprotic solvents such as acetonitrile, glass surfaces act as ‘green’ heterogeneous catalysts that can be recovered and reused after simple rinsing. Besides their use in organic reaction catalysis, glass surfaces are also found to act as degradation reagents for phospholipids with increasing extents of degradation occuring at low concentrations. This finding suggests that the storage of base/nucleophile-labile compounds or lipids in glass containers should be avoided. <br>

High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry

2021 ◽  
Vol 93 (17) ◽  
pp. 6792-6800
Author(s):  
Fan Pu ◽  
Andrew J. Radosevich ◽  
James W. Sawicki ◽  
David Chang-Yen ◽  
Nari N. Talaty ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Throughput ◽  
Electrospray Ionization Mass Spectrometry ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Label Free ◽  
Biochemical Assays

Versatile Platform Employing Desorption Electrospray Ionization Mass Spectrometry for High-Throughput Analysis

2008 ◽  
Vol 80 (15) ◽  
pp. 6131-6136 ◽  
Author(s):  
Xiaoxiao Ma ◽  
Mengxia Zhao ◽  
Ziqing Lin ◽  
Sichun Zhang ◽  
Chengdui Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Throughput ◽  
Electrospray Ionization Mass Spectrometry ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
High Throughput Analysis ◽  
Throughput Analysis

High-throughput screening of organic reactions in microdroplets using desorption electrospray ionization mass spectrometry (DESI-MS): hardware and software implementation

2020 ◽  
Vol 12 (28) ◽  
pp. 3654-3669
Author(s):  
Tiago Jose P. Sobreira ◽  
Larisa Avramova ◽  
Botond Szilagyi ◽  
David L. Logsdon ◽  
Bradley P. Loren ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Throughput ◽  
Electrospray Ionization Mass Spectrometry ◽  
High Throughput Screening ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Desi Ms ◽  
Novel Method

Implementation of a novel method for high-throughput screening of reactions in microdroplets. The reaction and analysis steps are performed simultaneously using desorption electrospray ionization mass spectrometry (DESI-MS) at a rate of up to 1 reaction mixture per second.

High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry

2020 ◽  
Vol 24 (9) ◽  
pp. 1647-1657
Author(s):  
David L. Logsdon ◽  
Yangjie Li ◽  
Tiago Jose Paschoal Sobreira ◽  
Christina R. Ferreira ◽  
David H. Thompson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Throughput ◽  
Electrospray Ionization Mass Spectrometry ◽  
High Throughput Screening ◽  
Reductive Amination ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass
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