The deoxyfluoro-d-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase
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1. The deoxyfluoro-d-glucopyranose 6-phosphates were prepared from the corresponding deoxyfluoro-d-glucoses and ATP by using hexokinase. 2. 3-Deoxy-3-fluoro- and 4-deoxy-4-fluoro-d-glucose 6-phosphate were substrates for glucose phosphate isomerase, and in addition the products of this reaction, 3-deoxy-3-fluoro- and 4-deoxy-4-fluoro-d-fructose 6-phosphate respectively, were good substrates for phosphofructokinase. 3. Some C-2-substituted derivatives of d-glucose 6-phosphate were found to be competitive inhibitors of glucose phosphate isomerase. 4. The possible role of the hydroxyl groups in the binding of d-glucose 6-phopshate to glucose phosphate isomerase is discussed.
1980 ◽
Vol 45
(2)
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pp. 427-434
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1981 ◽
Vol 116
(1)
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pp. 7-12
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2016 ◽
Vol 12
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pp. 2588-2601
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2015 ◽
Vol 170-171
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pp. 135-143
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