Immunoelectrophoretic studies on human small-intestinal brush-border proteins
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The amounts of lactase (beta-D-galactosidase, EC 3.2.1.23), sucrase (sucrose alpha-D-glucohydrolase, EC 3.2.1.48), maltase (alpha-D-glucosidase, EC 3.2.1.20) microvillus aminopeptidase (EC 3.4.11.2) and dipeptidyl peptidase IV (EC 3.4.14.-) in tangentially sectioned biopsies from jejunum were studied by quantitative immunoelectrophoresis and enzymic assays. All enzymes had their maximum activities near the mid-region of the villi and their lowest activities at the bases of the crypts. The ratio between enzyme activity and immunoreactive protein was constant along the villus-crypt axis. This result is consistent with a continuous brush-border-enzyme synthesis as the enterocytes migrate up the villi.
1978 ◽
Vol 90
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pp. 489-498
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1980 ◽
Vol 614
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pp. 210-214
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2007 ◽
Vol 48
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pp. 696-702
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2014 ◽
Vol 6
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pp. 71-79
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1999 ◽
Vol 274
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pp. 17961-17967
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1983 ◽
Vol 173
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pp. 372-378
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2003 ◽
Vol 36
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pp. 567-578
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