scholarly journals Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy

1993 ◽  
Vol 289 (1) ◽  
pp. 149-153 ◽  
Author(s):  
J K Lodge ◽  
S U Patel ◽  
P J Sadler
Keyword(s):  
Lipid Peroxidation ◽  
Metal Ion ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Fenton’S Reagent ◽  
Fenton's Reagent ◽  
Reactive Aldehydes

The modification of lipoproteins by reactive aldehydes formed via lipid peroxidation is thought to be a key process in the pathogenesis of atherosclerosis. We show that 1H-n.m.r. spectroscopy can readily be used to detect a variety of different aldehydes resulting from peroxidation of liposomes induced by Fenton's reagent or lipoxygenase, and aldehydes arising from copper-induced reactions of low-density lipoprotein. There is a clear contrast between the major aldehydic products arising from metal-ion- and lipoxygenase-induced reactions.

Plasma Paraoxonase-1, Oxidized Low-Density Lipoprotein and Lipid Peroxidation Levels in Gout Patients

2011 ◽  
Vol 61 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Xing-Liang Jiang ◽  
Min Li ◽  
Jing-Guo Zhou ◽  
Qi-Bin Yang ◽  
Li-Jun Du ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Paraoxonase 1 ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia

1995 ◽  
Vol 25 (3) ◽  
pp. 149-154 ◽  
Author(s):  
H. J. BLOM ◽  
H. A. KLEINVELD ◽  
G. H. J. BOERS ◽  
P. N. M. DEMACKER ◽  
H. L. M. HAK-LEMMERS ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

scholarly journals Resistance of lipoprotein(a) to lipid peroxidation induced by oxygenated free radicals produced by γ radiolysis: a comparison with low-density lipoprotein

1996 ◽  
Vol 314 (1) ◽  
pp. 277-284 ◽  
Author(s):  
Jean-Louis BEAUDEUX ◽  
Monique GARDES-ALBERT ◽  
Jacques DELATTRE ◽  
Alain LEGRAND ◽  
François ROUSSELET ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Peroxyl Radicals ◽  
Low Density ◽  
Lipoprotein A ◽  
Acetylneuraminic Acid ◽  
Paired Samples ◽  
Apolipoprotein A

Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-· /OH·, O2-·, O2-· /HO2·) produced by γ radiolysis was compared with that of paired samples of low-density lipoprotein (LDL). Lp(a) appeared to be more resistant to oxidation than LDL, as indicated by the kinetic study of four markers of lipid peroxidation: decrease in vitamin E, formation of conjugated dienes and aldehydic products, and modification of electrophoretic mobility. In contrast, similar kinetics of lipid peroxidation were obtained for LDL and Lp(a-), which is the lipoparticle issued following the reductive cleavage of apolipoprotein(a) from Lp(a), thus suggesting that the greater resistance of Lp(a) to lipid peroxidation was due to the presence of apolipoprotein(a). Lipid peroxidation of Lp(a) and LDL induced by peroxyl radicals, which were produced by an azo compound [2,2′-azobis-(2-amidinopropane)dihydrochloride], confirmed both the resistance of Lp(a) to lipid peroxidation and the propensity of Lp(a-) to exhibit a greater susceptibility to oxidation than intact Lp(a). Our findings also indicated that the high content of apolipoprotein(a) in N-acetylneuraminic acid residues was only partly responsible for the resistance of Lp(a) to oxidation.

The Simultaneous Generation of Superoxide and Nitric Oxide Can Initiate Lipid Peroxidation in Human Low Density Lipoprotein

1992 ◽  
Vol 17 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Victor M. Darley-usmar ◽  
Neil Hogg ◽  
Vanessa J. O'leary ◽  
Michael T. Wilson ◽  
Salvador Moncada
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Simultaneous Generation
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