Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation
Keyword(s):
E2F1 promoted miR-34c transcription which reduced its target stem cell factor (SCF) and inhibited colorectal cancer (CRC) cell proliferation. While, SCF increased E2F1 production, suggesting an existence of E2F1-miR-34c-SCF negative feedback loop, which was interrupted by hyper-methylation of miR-34c promoter in CRC cells.
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2021 ◽
Vol 558
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pp. 147-153
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2018 ◽
Vol 234
(5)
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pp. 7420-7434
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2018 ◽
Vol 63
(9)
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pp. 2320-2331
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2019 ◽
Vol Volume 11
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pp. 3741-3751
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