scholarly journals Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Chongxian Hou ◽  
Han Lin ◽  
Peng Wang ◽  
Yong Yang ◽  
Siyi Cen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Poor Survival ◽  
Who Grade ◽  
Grade Ii ◽  
Meta Analyses

Abstract CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognostic significance of CD44 in gliomas, and drew the conclusion that high expression of CD44 may predict poor survival in glioma, particularly in WHO grade II–III gliomas. However, two major defects exist in the present study, which made the meta-analysis on the prognostic significance of CD44 in all gliomas unreliable. In this commentary, we discussed the limitations and significance of the present study.

scholarly journals Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer

2019 ◽  
Vol 8 (4) ◽  
pp. CRC11 ◽  
Author(s):  
Chukwuemeka Ihemelandu ◽  
Aisha Naeem ◽  
Erika Parasido ◽  
Deborah Berry ◽  
Krysta Chaldekas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Marker ◽  
Prognostic Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Independent Prognostic Marker ◽  
Lgr5 Expression

Aim: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). Patients & methods: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009–2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray. Results: LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival. Conclusion: LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.

scholarly journals Prognostic value of cancer stem cell marker CD133 expression in esophageal carcinoma: A meta-analysis

2015 ◽  
Vol 4 (1) ◽  
pp. 77-82 ◽  
Author(s):  
YUN-PENG SUI ◽  
XUE-PING JIAN ◽  
LI MA ◽  
GUI-ZHEN XU ◽  
HUAI-WEI LIAO ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Esophageal Carcinoma ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Cd133 Expression

scholarly journals Prognostic Value of Cancer Stem Cell Marker Aldehyde Dehydrogenase in Ovarian Cancer: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81050 ◽  
Author(s):  
Shuyan Liu ◽  
Chengfei Liu ◽  
Xiaoyun Min ◽  
Yuanyuan Ji ◽  
Na Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Aldehyde Dehydrogenase ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II–III astrocytomas and oligoastrocytomas

2014 ◽  
Vol 117 (1) ◽  
pp. 183-189 ◽  
Author(s):  
Kimmo J. Hatanpaa ◽  
Tianshen Hu ◽  
Vamsidhara Vemireddy ◽  
Chan Foong ◽  
Jack M. Raisanen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Prognostic Factor ◽  
High Expression ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Who Grade ◽  
Adverse Prognostic Factor ◽  
Grade Ii

scholarly journals Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145164 ◽  
Author(s):  
Jinhuang Chen ◽  
Qinghua Xia ◽  
Bin Jiang ◽  
Weilong Chang ◽  
Wenzheng Yuan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Aldh1 Expression
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