Effects of pregnancy and lactation on insulin-stimulated fatty acid synthesis in rat white adipose tissue

1985 ◽  
Vol 13 (5) ◽  
pp. 863-864
Author(s):  
C. RUTH LENNOX ◽  
THOMAS B. CRABBE ◽  
MARJORIE MINSHULL
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Pregnancy And Lactation

scholarly journals Important sites of lipogenesis in the mouse other than liver and white adipose tissue

1981 ◽  
Vol 196 (2) ◽  
pp. 645-647 ◽  
Author(s):  
Marjorie A. Hollands ◽  
M. A. Cawthorne
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Major Site

The musculature of the shoulders and back has been identified as a major site of fatty acid synthesis in mice.

Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters

1991 ◽  
Vol 260 (1) ◽  
pp. R153-R158 ◽  
Author(s):  
A. J. Bhatia ◽  
G. N. Wade
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
De Novo ◽  
Acid Synthesis ◽  
De Novo Lipogenesis ◽  
Ovarian Steroids ◽  
Syrian Hamsters

The effects of pregnancy and ovarian steroids on the in vivo distribution of newly synthesized fatty acids (incorporation of tritium from 3H2O into fatty acid) in Syrian hamsters (Mesocricetus auratus) were examined. During late, but not early, gestation hamsters had reduced levels of newly synthesized fatty acids in heart, liver, uterus, and white adipose tissues (parametrial and inguinal fat pads). Treatment of ovariectomized hamsters with estradiol + progesterone significantly decreased fatty acid synthesis-uptake in heart, liver, and inguinal white adipose tissue. Treatment with either estradiol or progesterone alone was without significant effect in any tissue. Pretreatment of hamsters with Triton WR-1339 (tyloxapol), an inhibitor of lipoprotein lipase activity and tissue triglyceride uptake, abolished the effects of estradiol + progesterone in white adipose tissue and heart but not in liver. Thus hamsters lose body fat during pregnancy in part because of decreased de novo lipogenesis. The effect of pregnancy on lipogenesis is mimicked by treatment with estradiol + progesterone but not by either hormone alone. Furthermore, it appears that the liver is the principal site of estradiol + progesterone action on lipogenesis in Syrian hamsters.

Studies on the Control of Fatty Acid Synthesis in White Adipose Tissue of the Rat: Effect of Alanine

1972 ◽  
Vol 50 (12) ◽  
pp. 1326-1333 ◽  
Author(s):  
Mitchell L. Halperin
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Redox Potential ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
High Flow ◽  
Flow Rates ◽  
Fatty Acid Synthesis Pathway ◽  
Tricarboxylate Carrier

(1) Alanine resulted in inhibition of lipogenesis in adipocytes from normal fed rats incubated with glucose and insulin.(2) Two related mechanisms are suggested for the lower rates of lipogenesis caused by alanine metabolism. (a) Lower pyruvate levels were seen in the presence of alanine. This could contribute to the observed inhibition as pyruvate is an intermediate in the fatty acid synthesis pathway. Pyruvate levels were probably lowered as a result of the increased cytosol redox potential produced by high flow rates through malate dehydrogenase in this compartment, (b) Inhibition could be a consequence of depletion of malate in the cytosol which could limit the mitochondrial tricarboxylate carrier associated with citrate entry into the cytosol.(3) TMPD, an agent which lowers cytoplasmic redox potential, increased both the malate and pyruvate levels and increased the lipogenic rates nearly to normal in the presence of alanine.

Regional variations in metabolic responses of white adipose tissue to food restriction

1994 ◽  
Vol 267 (6) ◽  
pp. E892-E899 ◽  
Author(s):  
M. C. Sugden ◽  
R. M. Grimshaw ◽  
H. Lall ◽  
M. J. Holness
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
Food Restriction ◽  
Glucose Utilization ◽  
Acid Synthesis ◽  
Anatomical Location ◽  
Standard Laboratory Diet

The effects of food restriction (limited access to food for 2 h/day for 10 days) on lipoprotein lipase (LPL) activities and rates of fatty acid synthesis and glucose utilization in vivo in two superficial (interscapular and subcutaneous) and three deep abdominal white adipose tissue depots (parametrial, perirenal, and mesenteric) of adult female Wistar rats were examined before and at 2 h after a standard laboratory diet meal (5 g). Fasting LPL activities in perirenal (1.6-fold), mesenteric (5.9-fold), and subcutaneous (2.7-fold) adipose tissue, when expressed per unit of delipidated tissue, were increased in response to food restriction. This effect was retained (but not enhanced) after the meal. In contrast, muscle LPL activities were either unchanged or suppressed by food restriction. Stimulation of adipose tissue fatty acid synthesis and glucose utilization evoked by feeding in control rats was greatly enhanced by prior food restriction. There was no relationship between anatomical location and presence or absence of the response of adipose tissue LPL activity to food restriction, but the effect of food restriction to enhance the responses of fatty acid synthesis and glucose utilization to a meal was more marked in perirenal and parametrial adipose tissue than in the more superficial depots. The results thus demonstrate regional specificity in the response of adipose tissue functions to food restriction.

FATTY ACID SYNTHESIS IN NORMAL AND COLD-ACCLIMATED RATS

1964 ◽  
Vol 42 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Judith K. Patkin ◽  
E. J. Masoro
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Stomach Tube ◽  
Major Pathway

Rats acclimated to either 0–2 °C or 25 °C were given glucose-C14 via stomach tube and then sacrificed at [Formula: see text], 1, 6, or 24 hours. The cold-acclimated rats incorporated no more and possibly less C14 into fatty acids than did the rats acclimated to 25 °C. Evidence is presented which indicates that the white adipose tissue probably did not play a quantitatively important role in the conversion of the glucose-C14 to fatty acid. Also, the data indicate that lipogenesis was not a major pathway of the glucose-C14 metabolism.

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