Fatty acid composition of phospholipids from interscapular brown adipose tissue of obese and lean Zucker rats

1986 ◽  
Vol 14 (2) ◽  
pp. 287-288 ◽  
Author(s):  
K. W. J. WAHLE ◽  
T. E. C. WEEKES ◽  
J. M. FLETCHER
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Acid Composition ◽  
Zucker Rats ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose

Effect of noradrenaline chronic administration on brown fat phospholipids

1988 ◽  
Vol 8 (5) ◽  
pp. 465-469 ◽  
Author(s):  
Gérard Mory ◽  
Myriam Gawer ◽  
Jean-Claude Kader
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Acid Composition ◽  
Cold Exposure ◽  
Chronic Administration ◽  
Sympathetic Tone ◽  
Brown Fat ◽  
Brown Adipose

Chronic cold exposure of rats (9 days at 5°C) induces an alteration of the fatty acid composition of phospholipids in brown adipose tissue. The alteration is due to an increase of the unsaturation degree of these lipids. The phenomenon can be reproduced by 10−7 mole. h−1 administration of noradrenaline for 9 days in rats kept at 25°C. Thus, phospholipid alteration in brown fat of cold exposed rats is most probably a consequence of the increase of sympathetic tone which occurs in this tissue during exposure to cold.

scholarly journals Fatty acid composition of brown adipose tissue in dietary obese rats

IUBMB Life ◽  
1997 ◽  
Vol 43 (5) ◽  
pp. 1129-1136
Author(s):  
Isabel Lladó ◽  
Antoni Pons ◽  
Andreu Palou
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Acid Composition ◽  
Brown Adipose ◽  
Obese Rats

scholarly journals Evidence for a high fatty acid synthesis activity in interscapular brown adipose tissue of genetically obese Zucker rats

1982 ◽  
Vol 204 (2) ◽  
pp. 503-507 ◽  
Author(s):  
M Lavau ◽  
R Bazin ◽  
Z Karaoghlanian ◽  
C Guichard
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Synthetase ◽  
High Fatty Acid ◽  
Acid Synthesis ◽  
Zucker Rats ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose

Obese (fa/fa) rats (30 days old) exhibited a 50% increase in the weight of interscapular brown adipose tissue compared with their lean (Fa/fa) littermates. The tissue weight increase was accounted for by an increased fat content. Lipogenesis in vivo, as assessed by the incorporation of 3H from 3H2O into lipid, was increased 5-fold in brown adipose tissue of obese as compared with lean rats. Accordingly, acetyl-CoA carboxylase, fatty acid synthetase, citrate-cleavage enzyme and malic enzyme in this tissue were 4-8 times more active in obese than in lean rats.

Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation

1989 ◽  
Vol 256 (1) ◽  
pp. R146-R154 ◽  
Author(s):  
C. Carneheim ◽  
B. Cannon ◽  
J. Nedergaard
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Brown Adipose Tissue ◽  
Acid Composition ◽  
Brown Fat ◽  
Brown Adipose ◽  
Tissue Lipids

Because brown adipose tissue lipids are the preferred substrate for thermogenesis during arousal from hibernation, the fatty acid composition of brown fat lipids was followed during cold acclimation and during a hibernation bout. In control golden hamsters (living at 22 degrees C), the fatty acid composition of the white adipose tissue closely resembled that of the food, but brown adipose tissue contained more animal-derived fatty acids. As an effect of acclimation to cold, the fatty acid composition of brown adipose tissue changed to resemble that of the food, and no marked differences between white and brown adipose tissue were then evident. During a hibernation bout, a major part of the fatty acids accumulated in brown fat during entry into hibernation consisted of "rare" acids, such as homo-gamma-linoleic acid. Homo-gamma-linoleic, together with eicosadienoic acid and lignoceric acid, was preferentially utilized during the early phase of arousal. During this phase, "bulk" fatty acids, such as linoleic acid, were spared, whereas in late arousal, linoleic acid was the preferred substrate. It was concluded that rare fatty acids are of quantitative significance in brown adipose tissue during hibernation and arousal.

scholarly journals Rosiglitazone-induced changes in the oxidative stress metabolism and fatty acid composition in relation with trace element status in the primary adipocytes

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Duygu Aydemir ◽  
Ehsan Sarayloo ◽  
Nuriye Nuray Ulusu
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Trace Element ◽  
Acid Composition ◽  
Brown Adipose

Summary Background Metabolic syndrome, obesity and type 2 diabetes are metabolic disorders characterized by the insulin resistance and the impairment in the insulin secretion. Since impairment in the oxidative stress and adipocyte metabolism contribute to the formation of obesity and diabetes, targeting adipose tissue can be considered as an effective approach to fight against them. Rosiglitazone is used for treatment for patients with type 2 diabetes via inducing lipogenesis and transdifferentiation of white adipose tissue into brown adipose tissue. Since the development of such therapeutics is required to control the formation and function of brown fat cells, we aimed to reveal possible molecular mechanisms behind rosiglitazone induced biochemical changes in the adipose tissue. Methods Cells were expanded in the adipocyte culture medium supplemented with 5 μg/mL insulin following 2 days’ induction. After those cells were treated with rosiglitazone 0, 0.1 3 mol/L and 10 μmol/L rosiglitazone for 48 hours and at 8th day, cells were collected and stored at -80 °C. Then the cells were used to evaluate antioxidant enzyme activities, mineral and trace element levels and fatty acid composition. Results Glucose-6-phosphate dehydrogenase and glutathione reductase significantly reduced in rosiglitazone-treated groups compared to the control. Na, Mg, K, Ca, Cr, Fe, Ni, Cu, Zn, Rb, Sr, Cs, Ba and Pb were determined in the cell lysates via ICP-MS. Also, relative FAME content decreased in the rosiglitazone-treated groups compared to the control. Conclusions Rosiglitazone treatment at low doses showed promising results which may promote brown adipose tissue formation.

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