The effect of non-enzymic glycation on ligand binding to human serum albumin

1987 ◽  
Vol 15 (2) ◽  
pp. 267-268 ◽  
Author(s):  
GERALDINE FITZPATRICK ◽  
P. FINBARR DUGGAN
Keyword(s):  
Human Serum Albumin ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum

scholarly journals Temperature-Dependent Simultaneous Ligand Binding in Human Serum Albumin

2008 ◽  
Vol 112 (16) ◽  
pp. 4884-4891 ◽  
Author(s):  
Sudarson Sekhar Sinha ◽  
Rajib Kumar Mitra ◽  
Samir Kumar Pal
Keyword(s):  
Human Serum Albumin ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum ◽  
Temperature Dependent

Structural Basis of Drug Recognition by Human Serum Albumin

2020 ◽  
Vol 27 (30) ◽  
pp. 4907-4931 ◽  
Author(s):  
Loris Leboffe ◽  
Alessandra di Masi ◽  
Fabio Polticelli ◽  
Viviana Trezza ◽  
Paolo Ascenzi
Keyword(s):  
Human Serum Albumin ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Capacity ◽  
Pharmacological Therapy ◽  
Drug Binding ◽  
Structural Basis ◽  
Structural Determinants ◽  
Concurrent Administration

Background: Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule with at least nine binding sites for endogenous and exogenous ligands. HSA displays an extraordinary ligand binding capacity as a depot and carrier for many compounds including most acidic drugs. Consequently, HSA has the potential to influence the pharmacokinetics and pharmacodynamics of drugs. Objective: In this review, the structural determinants of drug binding to the multiple sites of HSA are analyzed and discussed in detail. Moreover, insight into the allosteric and competitive mechanisms underpinning drug recognition, delivery, and efficacy are analyzed and discussed. Conclusion: As several factors can modulate drug binding to HSA (e.g., concurrent administration of drugs competing for the same binding site, ligand binding to allosteric-coupled clefts, genetic inherited diseases, and post-translational modifications), ligand binding to HSA is relevant not only under physiological conditions, but also in the pharmacological therapy management.

scholarly journals Differential Effects of Methoxy Group on the Interaction of Curcuminoids with Two Major Ligand Binding Sites of Human Serum Albumin

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87919 ◽  
Author(s):  
Hiroki Sato ◽  
Victor Tuan Giam Chuang ◽  
Keishi Yamasaki ◽  
Noriyuki Yamaotsu ◽  
Hiroshi Watanabe ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Sites ◽  
Methoxy Group ◽  
Differential Effects ◽  
Ligand Binding Sites

scholarly journals The extraordinary ligand binding properties of human serum albumin

IUBMB Life ◽  
2005 ◽  
Vol 57 (12) ◽  
pp. 787-796 ◽  
Author(s):  
Mauro Fasano ◽  
Stephen Curry ◽  
Enzo Terreno ◽  
Monica Galliano ◽  
Gabriella Fanali ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Properties
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