Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of mitochondrial DNA?
2000 ◽
Vol 28
(2)
◽
pp. 154-159
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Keyword(s):
The mechanism of mitochondrial transcription is well documented although the method of regulation remains obscure. The mitochondrial transcription-termination complex, mTERF, holds a key position in determining the fate of heavy-strand promotor-initiated transcripts and has been suggested as a candidate in the regulation of mitochondrial DNA (mtDNA) transcription. We report here the first example of a modulation of mTERF-complex binding activity concomitant with a differential mtDNA transcription rate. We suggest that these observations are indicative of a method of intra-organellar transcriptional fine tuning.
2011 ◽
Vol 43
(6)
◽
pp. 472-479
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1993 ◽
Vol 13
(3)
◽
pp. 1951-1961
Keyword(s):