Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?

2007 ◽  
Vol 35 (4) ◽  
pp. 701-703 ◽  
Author(s):  
I. Podgorski ◽  
B.E. Linebaugh ◽  
B.F. Sloane
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Advanced Prostate Cancer ◽  
Bone Matrix ◽  
Cathepsin K ◽  
Collagen I ◽  
Skeletal Metastases ◽  
Bone Microenvironment ◽  
Prostate Cancer Cells ◽  
Common Site

The skeleton is the most common site of metastasis in patients with advanced prostate cancer. Despite many advances in targeting skeletal metastases, the mechanisms behind the attraction of prostate cancer cells to the bone are not known. Osteoclast cathepsin K, due to its ability to effectively degrade bone matrix collagen I, has been implicated in colonization and growth of prostate tumours in the bone. Identification of new cathepsin K substrates in the bone microenvironment and the recent findings demonstrating its involvement in obesity and inflammation suggest additional roles for this enzyme in skeletal metastases of prostate cancer.

scholarly journals Prostate Cancer and Bone: The Elective Affinities

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Nadia Rucci ◽  
Adriano Angelucci
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Bone Microenvironment ◽  
Prostate Cancer Cells ◽  
Common Site ◽  
Osteolytic Lesions ◽  
Molecular Events ◽  
Elective Affinities ◽  
Molecular Affinity

The onset of metastases dramatically changes the prognosis of prostate cancer patients, determining increased morbidity and a drastic fall in survival expectancy. Bone is a common site of metastases in few types of cancer, and it represents the most frequent metastatic site in prostate cancer. Of note, the prevalence of tumor relapse to the bone appears to be increasing over the years, likely due to a longer overall survival of prostate cancer patients. Bone tropism represents an intriguing challenge for researchers also because the preference of prostate cancer cells for the bone is the result of a sequential series of targetable molecular events. Many factors have been associated with the peculiar ability of prostate cancer cells to migrate in bone marrow and to determine mixed osteoblastic/osteolytic lesions. As anticipated by the success of current targeted therapy aimed to block bone resorption, a better understanding of molecular affinity between prostate cancer and bone microenvironment will permit us to cure bone metastasis and to improve prognosis of prostate cancer patients.

scholarly journals Phellinus Linteus Extract Sensitizes Advanced Prostate Cancer Cells to Apoptosis in Athymic Nude Mice

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9885 ◽  
Author(s):  
Takanori Tsuji ◽  
Wei Du ◽  
Takashi Nishioka ◽  
Lihua Chen ◽  
Daisuke Yamamoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Advanced Prostate Cancer ◽  
Phellinus Linteus ◽  
Prostate Cancer Cells ◽  
Athymic Nude Mice

An in vitro model of prostate cancer bone metastasis for highly metastatic and non-metastatic prostate cancer using nanoclay bone-mimetic scaffolds

MRS Advances ◽  
2019 ◽  
Vol 4 (21) ◽  
pp. 1207-1213 ◽  
Author(s):  
MD Shahjahan Molla ◽  
Dinesh R. Katti ◽  
Kalpana S. Katti
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Metastatic Prostate Cancer ◽  
Cancer Metastasis ◽  
Human Mesenchymal Stem Cells ◽  
Culture Technique ◽  
Complex Nature ◽  
Bone Microenvironment ◽  
Prostate Cancer Cells

ABSTRACTProstate cancer has a strong preference for metastasizing to bone which is the primary cause of prostate cancer-related morbidity and mortality. The complex nature of cancer metastasis requires the development of translational models that recapitulate a specific metastatic stage. Herein, we report the mimicking of mesenchymal to epithelial transition (MET) of prostate cancer cells using highly metastatic and a non-metastatic prostate cancer cell lines. A unique cell culture technique that we termed as ‘sequential culture’ was used to create a biomimetic bone microenvironment for metastasized prostate cancer cells by introducing bioactive factors from osteogenic induction of human mesenchymal stem cells (MSCs) within the porous 3D scaffolds. The in vitro 3D tumor model can be used as a testbed to study the interaction between prostate cancer and bone microenvironment and for the design of novel therapeutic studies.

scholarly journals Probing the Interaction Forces of Prostate Cancer Cells with Collagen I and Bone Marrow Derived Stem Cells on the Single Cell Level

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e57706 ◽  
Author(s):  
Ediz Sariisik ◽  
Denitsa Docheva ◽  
Daniela Padula ◽  
Cvetan Popov ◽  
Jan Opfer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Single Cell ◽  
Cancer Cells ◽  
Collagen I ◽  
Single Cell Level ◽  
Prostate Cancer Cells ◽  
Cell Level ◽  
Interaction Forces

Abstract 3359: Maspin induces MET in prostate cancer cells cultured in 3D-collagen I

2011 ◽  
Author(s):  
Ivory Dean ◽  
Margarida Bernardo ◽  
Xiaohua Li ◽  
Sijana Dzinic ◽  
Shuping Yin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Collagen I ◽  
Prostate Cancer Cells ◽  
3D Collagen ◽  
Cells Cultured

Abstract 770: MiR628-5p targets Jagged 1 and inhibits growth, stemness and invasiveness of advanced prostate cancer cells

2019 ◽  
Author(s):  
Leslimar Rios-Colon ◽  
Juliet Chijioke ◽  
Anvesha Srivastava ◽  
Malathi Ramalinga ◽  
Habib Kedir ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Advanced Prostate Cancer ◽  
Prostate Cancer Cells

Abstract 770: MiR628-5p targets Jagged 1 and inhibits growth, stemness and invasiveness of advanced prostate cancer cells

2019 ◽  
Author(s):  
Leslimar Rios-Colon ◽  
Juliet Chijioke ◽  
Anvesha Srivastava ◽  
Malathi Ramalinga ◽  
Habib Kedir ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Advanced Prostate Cancer ◽  
Prostate Cancer Cells

Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype

2005 ◽  
Vol 23 (32) ◽  
pp. 8232-8241 ◽  
Author(s):  
Robert D. Loberg ◽  
Christopher J. Logothetis ◽  
Evan T. Keller ◽  
Kenneth J. Pienta
Keyword(s):  
Prostate Cancer ◽  
Endothelial Cells ◽  
Tumor Cell ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Advanced Prostate Cancer ◽  
Metastatic Potential ◽  
Chemotherapeutic Agents ◽  
Bone Microenvironment ◽  
Lethal Phenotype

Traditionally, prostate cancer treatment, as well as all cancer treatment, has been designed to target the tumor cell directly via various hormonal and chemotherapeutic agents. Recently, the realization that cancer cells exist in complex microenvironments that are essential for the tumorigenic and metastatic potential of the cancer cells is starting the redefine the paradigm for cancer therapy. The propensity of prostate cancer cells to metastasize to bone is leading to the design of novel therapies targeting both the cancer cell as well as the bone microenvironment. Tumor cells in the bone interact with the extracellular matrix, stromal cells, osteoblasts, osteoclasts, and endothelial cells to promote tumor-cell survival and proliferation leading to a lethal phenotype that includes increased morbidity and mortality for patients with advanced prostate cancer. Several strategies are being developed that target these complex tumor cell–microenvironment interactions and target the signal transduction pathways of other cells important to the development of metastases, including the osteoclasts, osteoblasts, and endothelial cells of the bone microenvironment. Current and new therapies in metastatic prostate cancer will comprise a multitargeted approach aimed at both the tumor cell and the tumor microenvironment. Here, we review the current therapeutic strategies for targeting the prostate cancer–bone microenvironment and several single- and multiagent targeted approaches to the treatment of advanced prostate cancer that are under development.

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