Control of pancreatic development by intercellular signals

Understanding pancreatic development is important for at least three reasons: first, from a cognitive point of view, to understand the development of a complex organ, the pancreas; next, because it is now clear that abnormal pancreatic development can give rise to specific forms of diabetes in humans; and finally, because, if we want to define new treatments for diabetes based on cell therapy or regenerative medicine, we will have to understand in detail how β-cells develop. In the present paper, we summarize what we currently know concerning pancreatic development and concentrate on some intercellular and environmental signals controlling pancreatic development.

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Prácticas disruptivas en la medicina regenerativa y la terapia celular: de la heteronormatividad de laboratorio a la emergencia de nuevas exclusiones bioeconómicas

Clepsydra. Revista de Estudios de Género y Teoría Feminista ◽

10.25145/j.clepsydra.2021.20.02 ◽

2021 ◽

pp. 39-56

Author(s):

María José Miranda Suárez ◽

Keyword(s):

Regenerative Medicine ◽

Cell Therapy ◽

20Th Century ◽

Genetic Research ◽

Point Of View ◽

Economic Point ◽

Current Implementation ◽

Individual Consumption

Innovations in regenerative medicine and cell therapy have made possible multiple breakings in the laws and paradigms that determined the beginnings of 20th century biology. The destabilisation of categories and heteronormative dichotomies that demarcated this science made possible the irruption of studies that separated genetic research from sex. Even so, the current implementation of these techno-scientific developments produce other types of exclusion mechanisms we will analyse from a bio-economic point of view: from the reinforcement of the conditions of vulnerability of women donors, to the support of therapeutic promises that semiotically disconnect the contexts of uncertainty of these technologies or the implementation of a performative understanding of health in terms of individual consumption.

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The Role of Cellular Biology in Maxilo-facial Surgery and Protective Restorations

Revista de Chimie ◽

10.37358/rc.19.12.7761 ◽

2020 ◽

Vol 70 (12) ◽

pp. 4377-4380

Keyword(s):

Regenerative Medicine ◽

Cell Therapy ◽

Cell Biology ◽

Maxillofacial Surgery ◽

Point Of View ◽

Frontal Area ◽

Oral And Maxillofacial Surgery ◽

Human Communication ◽

Oral Rehabilitation ◽

The Individual

The essential characteristics of contemporary dental medicine are the precision, avant-garde, technologization and successful clinical purpose of cell therapy with the prospect of further application in the clinical practice of cell therapy methods and other performance methods based on the knowledge of cell biology and regenerative medicine in full function ; despite the very different environments, such teeth can develop normal in adult jaw; thus, if suitable cells can be found that, by combination, produce immature teeth, there is the potential for bio- teeth to become a clinical reality .The maxillary frontal area represents the most important area of the maxillae from an aesthetic point of view and the prosthetic restoration of this area is of primary interest in ensuring the appearance, phonation, incision, in human communication and in the structuring of the individual personality. Affecting the maxillary frontal area or through coronary destruction consecutive cavities and their complications, discolouration, dental malpositions disgraceful or due to lack of dental periodontal units creates problem in the aesthetic prosthetics. These changes existing at the front arcade level cause major disturbances to the physiognomy, to the phonation. In the Clinic of Oral and Maxillofacial Surgery, in a period of 2 years, between 2016 and 2018, we noticed, solved and followed a number of 129 cases; 57 patients-lot endodontic and surgical therapy study; 72 patients, study group prosthetic restorations. Due to the functional role that the maxillary front teeth play, the corrections have to be made within the limits of functional tolerance that fall within the normal occlusal parameters because the functional disturbances dictated only by the aesthetics are not tolerated and can lead to large imbalances. The complex oral rehabilitation of the different clinical cases encountered in the dental practice is largely a challenge for the dentist due to the high degree of different affect but present on all the elements of the system. Keywords: cell therapy method , regenerative medicine, prosthetic restoration

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Sous la direction de Jean-François Stoltz — Regenerative Medicine and Cell Therapy — Édité par Jean-François Stoltz (Nancy) — IOS Press — Biomedical and Health Research, 446 pages, 2012

Bulletin de l Académie Nationale de Médecine ◽

10.1016/s0001-4079(19)31637-1 ◽

2013 ◽

Vol 197 (1) ◽

pp. 191-192

Author(s):

Jacques Caen

Keyword(s):

Regenerative Medicine ◽

Cell Therapy ◽

Health Research

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iPSC technology-based regenerative medicine for kidney diseases

Clinical and Experimental Nephrology ◽

10.1007/s10157-021-02030-x ◽

2021 ◽

Author(s):

Kenji Osafune

Keyword(s):

Regenerative Medicine ◽

Cell Therapy ◽

Kidney Development ◽

Disease Modeling ◽

Kidney Diseases ◽

Collecting Duct ◽

Current Status ◽

Renal Tubules ◽

Discovery Research ◽

Drug Discovery Research

AbstractWith few curative treatments for kidney diseases, increasing attention has been paid to regenerative medicine as a new therapeutic option. Recent progress in kidney regeneration using human-induced pluripotent stem cells (hiPSCs) is noteworthy. Based on the knowledge of kidney development, the directed differentiation of hiPSCs into two embryonic kidney progenitors, nephron progenitor cells (NPCs) and ureteric bud (UB), has been established, enabling the generation of nephron and collecting duct organoids. Furthermore, human kidney tissues can be generated from these hiPSC-derived progenitors, in which NPC-derived glomeruli and renal tubules and UB-derived collecting ducts are interconnected. The induced kidney tissues are further vascularized when transplanted into immunodeficient mice. In addition to the kidney reconstruction for use in transplantation, it has been demonstrated that cell therapy using hiPSC-derived NPCs ameliorates acute kidney injury (AKI) in mice. Disease modeling and drug discovery research using disease-specific hiPSCs has also been vigorously conducted for intractable kidney disorders, such as autosomal dominant polycystic kidney disease (ADPKD). In an attempt to address the complications associated with kidney diseases, hiPSC-derived erythropoietin (EPO)-producing cells were successfully generated to discover drugs and develop cell therapy for renal anemia. This review summarizes the current status and future perspectives of developmental biology of kidney and iPSC technology-based regenerative medicine for kidney diseases.

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Cell Therapy and Bioengineering in Experimental Liver Regenerative Medicine: In Vivo Injury Models and Grafting Strategies

Current Transplantation Reports ◽

10.1007/s40472-021-00325-2 ◽

2021 ◽

Author(s):

G. Amato ◽

T. Saleh ◽

G. Carpino ◽

E. Gaudio ◽

D. Alvaro ◽

...

Keyword(s):

Regenerative Medicine ◽

Cell Therapy ◽

Cell Delivery ◽

Effective Strategies ◽

Multiple Strategies ◽

End Stage ◽

Therapy Strategies ◽

Injury Models ◽

Experimental Liver

Abstract Purpose of Review To describe experimental liver injury models used in regenerative medicine, cell therapy strategies to repopulate damaged livers and the efficacy of liver bioengineering. Recent Findings Several animal models have been developed to study different liver conditions. Multiple strategies and modified protocols of cell delivery have been also reported. Furthermore, using bioengineered liver scaffolds has shown promising results that could help in generating a highly functional cell delivery system and/or a whole transplantable liver. Summary To optimize the most effective strategies for liver cell therapy, further studies are required to compare among the performed strategies in the literature and/or innovate a novel modifying technique to overcome the potential limitations. Coating of cells with polymers, decellularized scaffolds, or microbeads could be the most appropriate solution to improve cellular efficacy. Besides, overcoming the problems of liver bioengineering may offer a radical treatment for end-stage liver diseases.

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Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

Regenerative Medicine ◽

10.2217/rme-2021-0069 ◽

2021 ◽

Author(s):

Lianxu Cui ◽

Yasmeen Saeed ◽

Haomin Li ◽

Jingli Yang

Keyword(s):

Traumatic Brain Injury ◽

Stem Cells ◽

Stem Cell ◽

Brain Injury ◽

Regenerative Medicine ◽

Cell Therapy ◽

Therapeutic Strategies ◽

Study Data ◽

Health Concern ◽

Standardized Treatment

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

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