A Non-Invasive Technique for the Direct Determination of Hepatic Extraction and Systemic Clearance of Indocyanine Green in Baboons and Man

1982 ◽  
Vol 62 (2) ◽  
pp. 30P-30P
Author(s):  
S.L. Grainger ◽  
P.W.N. Keeling ◽  
J.H. Marigold ◽  
R.P.H. Thompson
Keyword(s):  
Indocyanine Green ◽  
Direct Determination ◽  
Invasive Technique ◽  
Systemic Clearance ◽  
Hepatic Extraction ◽  
Non Invasive

Clearance and Non-Invasive Determination of the Hepatic Extraction of Indocyanine Green in Baboons and Man

1983 ◽  
Vol 64 (2) ◽  
pp. 207-212 ◽  
Author(s):  
S. L. Grainger ◽  
P. W. N. Keeling ◽  
I. M. H. Brown ◽  
J. H. Marigold ◽  
R. P. H. Thompson
Keyword(s):  
Indocyanine Green ◽  
Accurate Determination ◽  
Liver Blood Flow ◽  
Compartment Model ◽  
Hepatic Extraction ◽  
Non Invasive ◽  
Two Compartment Model ◽  
Hepatic Extraction Ratio ◽  
Plasma Disappearance Curve

1. The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and noninvasively after a single intravenous injection of ICG.

Non-invasive Prenatal Determination of Fetal Maturity

2016 ◽  
Vol 70 (3) ◽  
pp. 153-157
Author(s):  
Elena Dzikova ◽  
Goran Dimitrov ◽  
Olivera Stojceva-Taneva
Keyword(s):  
Gestational Age ◽  
Lamellar Body ◽  
Invasive Technique ◽  
Non Invasive ◽  
Gynecology And Obstetrics ◽  
Fetal Maturity ◽  
Invasive Method ◽  
The University ◽  
Body Count

Abstract Aims. The prenatal prediction of fetal maturity is very important, since neonatal respiratory distress syndrome (RDS) is one of the biggest causes of neonatal mortality. Our aim was to investigate a new non-invasive method for prediction of fetal maturity and to determine in which group according to gestational age of the fetus, the treatment works the best and in which cases it is necessary to be repeated. Methods. We examined 60 patients (30 with impending preterm delivery, divided in 3 groups: 28-30, 30-32, and 32-34 gestational weeks and 30 controls), at the University Clinic for Gynecology and Obstetrics, Medical Faculty, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia. Fetal maturity was examined using ultrasound histogram from fetal lungs and liver, correlated with gestational age and postpartum RDS. Where possible, we performed amniocentesis for lamellar body count (LBC) to correlate our results with the current invasive method for prediction of fetal maturity. Results. Pre-therapy investigation showed a strong fetal immaturity in 28-32 weeks of gestation and less evident fetal immaturity in 32-34 weeks of gestation. Seventy-two hours post-treatment, fetal maturation was low in the first group, higher in the second and the highest in the third group. Amniocentesis for LBC showed correlation with the ultrasound results. Postpartum results were correlated with pre-delivery ultrasound and showed significance of p <0.05. Conclusion. The results obtained in our study were with high significance, and they were in correlation with other similar studies. However, more extensive investigations should be made to replace the current invasive technique.

P6.16 DETERMINATION OF CAROTID AND FEMORAL WAVE SPEED AND DISTENSIBILITY IN A HEALTHY POPULATION USING A NEW NON-INVASIVE TECHNIQUE

2011 ◽  
Vol 5 (4) ◽  
pp. 176
Author(s):  
A. Borlotti ◽  
S. Vermeersch ◽  
E. Rietzschel ◽  
P. Segers ◽  
A.W. Khir
Keyword(s):  
Wave Speed ◽  
Invasive Technique ◽  
Healthy Population ◽  
Non Invasive

scholarly journals Thoracic electrical bioimpedance in the follow-up of patients with cardiovascular disorders

2005 ◽  
Vol 133 (5-6) ◽  
pp. 297-302
Author(s):  
Vesna Stojanov ◽  
Mirko Saranovic ◽  
Branko Jakovljevic ◽  
Katarina Paunovic
Keyword(s):  
High Frequency ◽  
Invasive Technique ◽  
Non Invasive ◽  
Arterial Blood ◽  
Thoracic Electrical Bioimpedance ◽  
Patients With Heart Failure ◽  
Before And After ◽  
Electrical Bioimpedance ◽  
Low Amplitude

Thoracic electrical bioimpedance is a new non-invasive technique for obtaining haemodynamic parameters. The method involves the passing of low amperage, high frequency current through the thorax. The current induces a change of resistance within the thorax, which is registered by electrodes. The overall impedance of the thorax is a measure of the electrical resistance of the thorax to this high frequency, low amplitude current. In clinical practice, thoracic electrical bioimpedance has been applied in diagnostic, therapeutic, and prognostic use in patients with heart failure and hypertension, patients with pacemakers, within the scope of early diagnosis of implant rejection following heart transplantation, as well as in patients with kidney disorders, before and after dialysis. However, one of its most important applications is in the determination of antihypertensive therapy, because it provides the parameters that reflect the genesis of arterial blood pressure, in assessing these parameters, optimal therapy adjusted to the haemodynamic status of each patient can be prescribed.

Determination of Fetal Maturity Using Signal Transformations of Fetal Thalamus Estimating Fetal Maturity by Ultrasound

2017 ◽  
Vol 71 (1) ◽  
pp. 32-37
Author(s):  
Elena Dzikova ◽  
Goran Dimitrov ◽  
Olivera Stojceva-Taneva ◽  
Gligor Dimitrov
Keyword(s):  
Preterm Birth ◽  
Brain Tissue ◽  
Gestational Age ◽  
Fetal Lung ◽  
Invasive Technique ◽  
Lung Maturation ◽  
Non Invasive ◽  
Gynecology And Obstetrics ◽  
Fetal Maturity

Abstract Introduction. The complications associated with preterm birth are still the primary cause of death in children below 5 years of age, leading to nearly 1 million death cases in 2013. We performed our study to examine a new non-invasive method for prediction of fetal maturity. Methods. The study was designed asa prospective observational-interventional clinical study, conducted at the University Clinic for Gynecology and Obstetrics, Medical Faculty, University Ss. Cyril and Methodius Skopje, Republic of Macedonia. Ninety pregnant patients were examined, 48 with preterm birth used as examined cases and 42 women above 37 completed weeks of gestation and delivered at term, used as control cases. The investigation was performed before and 72 hours after administration of the therapy protocol for fetal lung maturation. The measurement was done with an ultrasound histogram software, measuring the density of thalamus and surrounding brain tissue. The results were followed up to 72 hours and then compared with the postpartum respiratory distress syndrome (RDS). If the patient was not delivered within 72 hours of measurement, she was excluded from the study. Results. In the first and in the second gestational age group, we noticed significant fetal maturation. All groups according to nationality and religionshowed high significance before and after treatment. The correlation among the thalamus density vs. surrounding brain tissue and postpartum RDS in all three groups according to gestational age, nationality and religion was high. Conclusion. Measuring the density of fetal thalamus vs. surrounding brain tissue may become the new non-invasive technique for determination of fetal maturity.

First use of a non-invasive technique for determination of sex hormones in the queen conch Lobatus gigas, Mollusca Gastropoda

2019 ◽  
Vol 27 (2) ◽  
pp. 437-448 ◽  
Author(s):  
Fabiola Chong Sánchez ◽  
Martha Enriquez Díaz ◽  
Eric Murillo Rodríguez ◽  
Dalila Aldana Aranda
Keyword(s):  
Sex Hormones ◽  
Invasive Technique ◽  
Queen Conch ◽  
Non Invasive

Direct determination of hepatic extraction of verapamil in cardiac patients

1981 ◽  
Vol 30 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Barry G Woodcock ◽  
Wolfgang Schulz ◽  
Gisbert Kober ◽  
Norbert Rietbrock
Keyword(s):  
Direct Determination ◽  
Cardiac Patients ◽  
Hepatic Extraction
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