Determination of Fetal Maturity Using Signal Transformations of Fetal Thalamus Estimating Fetal Maturity by Ultrasound

2017 ◽  
Vol 71 (1) ◽  
pp. 32-37
Author(s):  
Elena Dzikova ◽  
Goran Dimitrov ◽  
Olivera Stojceva-Taneva ◽  
Gligor Dimitrov
Keyword(s):  
Preterm Birth ◽  
Brain Tissue ◽  
Gestational Age ◽  
Fetal Lung ◽  
Invasive Technique ◽  
Lung Maturation ◽  
Non Invasive ◽  
Gynecology And Obstetrics ◽  
Fetal Maturity

Abstract Introduction. The complications associated with preterm birth are still the primary cause of death in children below 5 years of age, leading to nearly 1 million death cases in 2013. We performed our study to examine a new non-invasive method for prediction of fetal maturity. Methods. The study was designed asa prospective observational-interventional clinical study, conducted at the University Clinic for Gynecology and Obstetrics, Medical Faculty, University Ss. Cyril and Methodius Skopje, Republic of Macedonia. Ninety pregnant patients were examined, 48 with preterm birth used as examined cases and 42 women above 37 completed weeks of gestation and delivered at term, used as control cases. The investigation was performed before and 72 hours after administration of the therapy protocol for fetal lung maturation. The measurement was done with an ultrasound histogram software, measuring the density of thalamus and surrounding brain tissue. The results were followed up to 72 hours and then compared with the postpartum respiratory distress syndrome (RDS). If the patient was not delivered within 72 hours of measurement, she was excluded from the study. Results. In the first and in the second gestational age group, we noticed significant fetal maturation. All groups according to nationality and religionshowed high significance before and after treatment. The correlation among the thalamus density vs. surrounding brain tissue and postpartum RDS in all three groups according to gestational age, nationality and religion was high. Conclusion. Measuring the density of fetal thalamus vs. surrounding brain tissue may become the new non-invasive technique for determination of fetal maturity.

Non-invasive Prenatal Determination of Fetal Maturity

2016 ◽  
Vol 70 (3) ◽  
pp. 153-157
Author(s):  
Elena Dzikova ◽  
Goran Dimitrov ◽  
Olivera Stojceva-Taneva
Keyword(s):  
Gestational Age ◽  
Lamellar Body ◽  
Invasive Technique ◽  
Non Invasive ◽  
Gynecology And Obstetrics ◽  
Fetal Maturity ◽  
Invasive Method ◽  
The University ◽  
Body Count

Abstract Aims. The prenatal prediction of fetal maturity is very important, since neonatal respiratory distress syndrome (RDS) is one of the biggest causes of neonatal mortality. Our aim was to investigate a new non-invasive method for prediction of fetal maturity and to determine in which group according to gestational age of the fetus, the treatment works the best and in which cases it is necessary to be repeated. Methods. We examined 60 patients (30 with impending preterm delivery, divided in 3 groups: 28-30, 30-32, and 32-34 gestational weeks and 30 controls), at the University Clinic for Gynecology and Obstetrics, Medical Faculty, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia. Fetal maturity was examined using ultrasound histogram from fetal lungs and liver, correlated with gestational age and postpartum RDS. Where possible, we performed amniocentesis for lamellar body count (LBC) to correlate our results with the current invasive method for prediction of fetal maturity. Results. Pre-therapy investigation showed a strong fetal immaturity in 28-32 weeks of gestation and less evident fetal immaturity in 32-34 weeks of gestation. Seventy-two hours post-treatment, fetal maturation was low in the first group, higher in the second and the highest in the third group. Amniocentesis for LBC showed correlation with the ultrasound results. Postpartum results were correlated with pre-delivery ultrasound and showed significance of p <0.05. Conclusion. The results obtained in our study were with high significance, and they were in correlation with other similar studies. However, more extensive investigations should be made to replace the current invasive technique.

scholarly journals Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mary T. Kinney ◽  
Sara K. Quinney ◽  
Hayley K. Trussell ◽  
Larissa L. Silva ◽  
Sherrine A. Ibrahim ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Race And Ethnicity ◽  
Fetal Lung ◽  
Control Analysis ◽  
Lung Maturation ◽  
Maternal Characteristics ◽  
Individualization Of Therapy ◽  
Gestational Age At Birth ◽  
Age At Birth

Abstract Background Betamethasone (BMZ) is used to accelerate fetal lung maturation in women with threatened preterm birth, but its efficacy is variable and limited by the lack of patient individualization in its dosing and administration. To determine sources of variability and potential opportunities for individualization of therapy, the objective of this study was to evaluate maternal factors associated with development of neonatal respiratory distress syndrome (RDS) in a cohort of women who received betamethasone. Methods This study prospectively enrolled women, gestational ages 23–34 weeks, who received betamethasone for threatened preterm birth. Maternal demographics, prenatal history, and neonatal outcomes were abstracted from hospital records. RDS was the primary outcome. Associations between RDS diagnosis and maternal demographics, prenatal history, and betamethasone dosing were evaluated in a case-control analysis and multivariable regression adjusted for gestational age at delivery. Secondary analyses limited the cohort to women who delivered within 1 or 2 weeks of betamethasone dosing. Results Of 209 deliveries, 90 (43 %) resulted in neonatal RDS. Within the overall cohort and controlling for gestational age at birth, RDS was only associated with cesarean births compared to vaginal births (adjusted OR 1.17 [1.06–1.29]). Route of delivery was also the only significant factor related to RDS in the 83 neonates delivered within 7 days of BMZ dosing. However, among 101 deliveries within 14 days of betamethasone dosing and controlling for gestational age at birth, women who experienced preterm premature rupture of membranes (PPROM) had lower RDS rates than those without PPROM (57.9 % vs. 80.2 %, adjusted OR 0.81 [0.67–0.99]). Maternal age, BMI, race, and ethnicity were not associated with RDS in the regression models. Conclusions Of maternal characteristics analyzed, only delivery by cesarean was associated with neonatal RDS after antenatal betamethasone use.

scholarly journals PHOSPHATIDYLGLYCEROL STUDY AS FETAL LUNG MATURATION PARAMETER AFTER DEXAMETHASONE ADMINISTRATION FOR WOMEN AT RISK OF PRETERM BIRTH

2017 ◽  
Vol 52 (4) ◽  
pp. 264
Author(s):  
Rizal Umar Rahmadani ◽  
Agus Sulistyono ◽  
Yulistiani Yulistiani ◽  
Muhammad Yahya
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Fetal Lung ◽  
Mean Value ◽  
Lung Maturation ◽  
Important Indicator ◽  
Lipoprotein Complex ◽  
The Mean ◽  
Fetal Lung Maturation ◽  
Prospective Longitudinal

Phosphatidylglycerol is an important indicator of fetal lung maturation, which plays a role in stabilizing surfactant lipoprotein complex. Corticosteroid antenatal can stimulate the synthesis of pulmonary surfactant in infants with preterm birth. The objective of this study is to examine the phosphatidylglycerol levels as fetal lung maturation parameter after dexamethasone administration in women with preterm birth compared to L/S ratio parameter. This study was prospective longitudinal (cohort). The samples were pregnant women with preterm birth risk at 28-34 weeks gestation getting the therapy of antenatal dexamethasone 6 mg IM every 12 hours given 4 times in 48 hours. The samples were 17 patients. Determination of L/S ratio and PG levels was performed by ELISA. The study was conducted from May - November 2015 and reviewed to obtain ethics eligibility permit by the research ethic committees of Dr. Soetomo General Hospital. The results show that the mean value of L/S ratio is 2.28 with a range of 1.35 to 9.06 and the mean of PG level is 1.17 with a range from 0 to 3.79. L/S ratio and PG show no significant relationship between the two of them. Increased levels of PG on the gestational age of 28-32 weeks have not demonstrated clinically significant changes yet. The highest PG level occurs in the gestational age of 32-34 weeks.

scholarly journals Antenatal betamethasone augments early rise in pulmonary perfusion at birth in preterm lambs: role of ductal shunting and right ventricular outflow distribution

2019 ◽  
Vol 316 (6) ◽  
pp. R716-R724
Author(s):  
Joseph J. Smolich ◽  
Kelly R. Kenna ◽  
Jonathan P. Mynard
Keyword(s):  
Blood Flow ◽  
Preterm Birth ◽  
Right Ventricular ◽  
Ductus Arteriosus ◽  
Fetal Lung ◽  
Lung Maturation ◽  
Cord Clamping ◽  
Pulmonary Arterial ◽  
Early Rise ◽  
Fetal Lung Maturation

The glucocorticosteroid betamethasone is routinely administered via maternal intramuscular injection to enhance fetal lung maturation before anticipated preterm birth. Although antenatal betamethasone increases fetal pulmonary arterial (PA) blood flow, whether this agent alters the contribution of 1) right ventricular (RV) output or 2) left-to-right shunting across the ductus arteriosus to rises in PA blood flow after preterm birth is unknown. To address this question, anesthetized control ( n = 7) and betamethasone-treated ( n = 7) preterm fetal lambs (gestation 127 ± 1 days, means ± SD) were instrumented with aortic, pulmonary, and left atrial catheters as well as ductus arteriosus and left PA flow probes to calculate RV output, with hemodynamics measured for 30 min after cord clamping and mechanical ventilation. Mean PA blood flow was higher in betamethasone-treated than in control lambs over the initial 10 min after birth ( P < 0.05). This higher PA flow was accompanied by 1) a greater pulmonary vascular conductance ( P ≤ 0.025), 2) a larger proportion of RV output passing to lungs ( P ≤ 0.01), despite a fall in this output, and 3) earlier reversal and a greater magnitude ( P ≤ 0.025) of net ductal shunting, due to the combination of higher left-to-right ( P ≤ 0.025) and lesser right-to-left phasic shunting ( P ≤ 0.025). These results suggest that antenatal betamethasone augments the initial rise in PA blood flow after birth in preterm lambs, with this augmented rise supported by the combination of 1) a greater redistribution of RV output toward the lungs and 2) a faster and larger reversal in net ductal shunting underpinned not only by greater left-to-right, but also by lesser right-to-left phasic shunting.

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

2013 ◽  
Author(s):  
Fiona C Brownfoot ◽  
Daniela I Gagliardi ◽  
Emily Bain ◽  
Philippa Middleton ◽  
Caroline A Crowther
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Fetal Lung ◽  
Lung Maturation ◽  
Fetal Lung Maturation

P6.16 DETERMINATION OF CAROTID AND FEMORAL WAVE SPEED AND DISTENSIBILITY IN A HEALTHY POPULATION USING A NEW NON-INVASIVE TECHNIQUE

2011 ◽  
Vol 5 (4) ◽  
pp. 176
Author(s):  
A. Borlotti ◽  
S. Vermeersch ◽  
E. Rietzschel ◽  
P. Segers ◽  
A.W. Khir
Keyword(s):  
Wave Speed ◽  
Invasive Technique ◽  
Healthy Population ◽  
Non Invasive
Sign in / Sign up

Export Citation Format

Share Document