The Effect of High Sodium Intake on Bone Mineral Content in Rats fed Normal Calcium or low Calcium Diet

1993 ◽  
Vol 84 (s28) ◽  
pp. 8P-9P ◽  
Author(s):  
A Y S Chan ◽  
P Poon ◽  
E L P Chan ◽  
S L M Fung ◽  
R Swaminathan
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Sodium Intake ◽  
High Sodium ◽  
High Sodium Intake ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Normal Calcium

The effect of high sodium intake on bone mineral content in rats fed a normal calcium or a low calcium diet

1993 ◽  
Vol 3 (6) ◽  
pp. 341-344 ◽  
Author(s):  
A. Y. S. Chan ◽  
P. Poon ◽  
E. L. P. Chan ◽  
S. L. M. Fung ◽  
R. Swaminathan
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Sodium Intake ◽  
High Sodium ◽  
High Sodium Intake ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Normal Calcium

Involvement of low-calcium diet in the reduced bone mineral content of idiopathic renal stone formers

1990 ◽  
Vol 46 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Michel Fuss ◽  
Thierry Pepersack ◽  
Jean Van Geel ◽  
Jacques Corvilain ◽  
Jean-Claude Vandewalle ◽  
...  
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Renal Stone ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Stone Formers

scholarly journals Lack of Insulin-Like Growth Factor I Exaggerates the Effect of Calcium Deficiency on Bone Accretion in Mice

Endocrinology ◽  
2003 ◽  
Vol 144 (11) ◽  
pp. 4682-4689 ◽  
Author(s):  
Yuji Kasukawa ◽  
David J. Baylink ◽  
Jon E. Wergedal ◽  
Yousef Amaar ◽  
Apurva K. Srivastava ◽  
...  
Keyword(s):  
Calcium Deficiency ◽  
Growth Phases ◽  
Active Growth ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Igf I ◽  
Normal Calcium

Abstract Recent studies provide evidence that the GH/IGF-I axis plays a critical role in the regulation of bone accretion that occurs during puberty and that the peak bone mineral density (BMD) is dependent on the amount of dietary calcium intake during the active growth phases. To evaluate whether IGF-I deficiency exaggerates the effect of calcium deficiency on bone accretion during active growth phases, IGF-I knockout (KO) and wild-type (WT) mice were fed with low calcium (0.01%) or normal calcium (0.6%) for 2 wk during the pubertal growth phase and were labeled with tetracycline. The low calcium diet caused significant decreases in endosteal bone formation parameters and a much greater increase in the resorbing surface of both the endosteum and periosteum of the tibia of IGF-I KO mice compared with WT mice. Accordingly, femur BMD measured by dual energy x-ray absorptiometry or peripheral quantitative computed tomography increased significantly in IGF-I WT mice fed the low calcium diet, but not in IGF-I KO mice. IGF-I-deficient mice fed the normal calcium diet showed elevated PTH levels, decreased serum 1,25-dihydroxyvitamin D and serum calcium levels at baseline. Serum calcium changes due to calcium deficiency were greater in IGF-I KO mice compared with WT mice. PTH levels were 7-fold higher in IGF-I KO mice fed normal calcium compared with WT mice, which was further elevated in mice fed the low calcium diet. Treatment of IGF-I-deficient lit/lit mice with GH decreased the serum PTH level by 70% (P < 0.01). Based on these and past findings, we conclude that: 1) IGF-I deficiency exaggerates the negative effects of calcium deficiency on bone accretion; and 2) IGF-I deficiency may lead to 1,25-dihydroxyvitamin D deficiency and elevated PTH levels even under normal calcium diet.

Effect of Vitamin D Deficiency on Aminoaciduria and Intestinal Transport of Amino Acids in the Rat

1974 ◽  
Vol 52 (5) ◽  
pp. 972-977
Author(s):  
Claude L. Morin ◽  
Jean Léveillé ◽  
Victor Ling
Keyword(s):  
Amino Acids ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Intestinal Transport ◽  
Calcium Content ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Normal Calcium

Generalized hyperaminoaciduria and hyperphosphaturia are associated with human vitamin D deficiency rickets and the effect has been reproduced in animals. The basis for the renal transport impairment was attributed to secondary hyperparathyroidism resulting from hypocalcemia.In this study we attempted over a 16-week period to induce hyperaminoaciduria in Holtzman rats with vitamin D deficient diets of varying calcium content (0.4% and 0.04%) so as to investigate the possibility of a concomitant defect in intestinal transport of amino acids. Despite signs of secondary hyperparathyroidism, generalized hyperaminoaciduria was not in evidence in any of the groups. However, increased urinary excretion of lysine and taurine was demonstrated in rats fed a low calcium diet without vitamin D (LCa−D). The same observation was also made for taurine in rats deprived of vitamin D and on a normal calcium diet (NCa−D) and in animals fed a low calcium diet with vitamin D (LCa+D). The results failed to show any effect of vitamin D deficiency, hypocalcemia, or secondary hyperparathyroidism on the intestinal transport of lysine, alanine, and cycloleucine.

The Effects of an Educational Intervention on Calcium Intake and Bone Mineral Content in Young Women with Low Calcium Intake

2000 ◽  
Vol 14 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Britt Ann Peterson ◽  
Robert C. Klesges ◽  
Elizabeth M. Kaufman ◽  
Theodore V. Cooper ◽  
Christopher M. Vukadinovich
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Educational Intervention ◽  
Young Women ◽  
Calcium Intake ◽  
Mineral Content ◽  
Low Calcium

scholarly journals PTH and 1.25 vitamin D response to a low-calcium diet is associated with bone mineral density in renal stone formers

2008 ◽  
Vol 23 (8) ◽  
pp. 2563-2570 ◽  
Author(s):  
A. Pasch ◽  
F. J. Frey ◽  
U. Eisenberger ◽  
M. G. Mohaupt ◽  
O. Bonny
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Renal Stone ◽  
Mineral Density ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Stone Formers

Calcium transport in the ileum of uremic rats

1982 ◽  
Vol 242 (2) ◽  
pp. G128-G134
Author(s):  
M. Koller ◽  
U. Binswanger
Keyword(s):  
Renal Failure ◽  
Calcium Transport ◽  
Dihydroxyvitamin D3 ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Unidirectional Fluxes ◽  
Small Intestinal ◽  
Normal Calcium

Duodenal and ileal calcium transport was studied by 45Ca uptake and estimation of unidirectional fluxes in vitro in kidney-intact and 5/6-nephrectomized rats. After normal-calcium diet, calcium transport was impaired by uremia in the duodenum but not in the ileum. However, 5/6-nephrectomized rats on low-calcium diet showed, in concert with impaired growth, a reduced calcium transport both in duodenum and ileum. Comparing data after normal- and low-calcium diets, the ileal adaptation to low-calcium diet was intact in mild renal failure but abolished in severe uremia (urea less than 100 mg/dl). These results suggest that ileal calcium transport after normal-calcium diet is mainly passive. Taking into account reduced food intake as an additional factor, the active ileal calcium transport after low-calcium diet declines with progressive renal failure according to decreasing levels of 1,25-dihydroxyvitamin D3. A suspected enhancement of the distal small intestinal calcium transport by parathyroid hormone in uremic rats as compensation for proximally impaired absorption could not be demonstrated.

A low calcium diet during pregnancy and lactation of rats decreases their bone mineral density, milk production, litter weight, and body calcium

Bone ◽  
2001 ◽  
Vol 29 (3) ◽  
pp. 306 ◽  
Author(s):  
S. Zeni ◽  
A. Weisstaub ◽  
P. Rpnayne de Ferrer ◽  
S. Di Gregorio ◽  
M. Portela ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Milk Production ◽  
Bone Mineral ◽  
Mineral Density ◽  
Litter Weight ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Pregnancy And Lactation

The effects of diets deficient in phosphorus, phosphorus and vitamin D, or calcium, on the skeleton and teeth of the growing sheep. II. Malocclusion of the teeth

1965 ◽  
Vol 65 (1) ◽  
pp. 11-14 ◽  
Author(s):  
M. R. McRoberts ◽  
R. Hill ◽  
A. C. Dalgarno
Keyword(s):  
Vitamin D ◽  
Mineral Content ◽  
Treatment Effects ◽  
Control Diet ◽  
Calcium Content ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Molar Teeth

1. In growing sheep fed on a low-calcium diet for 12 months and for a similar period on a diet of adequate mineral content, a tendency for the incisor teeth to protrude beyond the maxillary pad (prognathism) was observed. This arose primarily during the repair period, and was apparently caused by poorer repair of the upper skull than of the mandible. This was not observed in animals fed on a control diet or one deficient in phosphorus and vitamin D.2. A malocclusion of molar teeth associated with poorly mineralized and extremely weak mandibles, which prevented the incisor teeth from meeting the dental pad, occurred in growing sheep fed for 12 months on a diet deficient in phosphorus and vitamin D. This defect was not observed in similar animals fed on a control diet nor in those fed on a diet of low calcium content. Treatment effects on the shape of the mandible that were apparently related to this malocclusion are described.

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