Baseline heart rate variability in healthy centenarians: differences compared with aged subjects (>75 years old)

1999 ◽  
Vol 97 (5) ◽  
pp. 579-584 ◽  
Author(s):  
Giuseppe PAOLISSO ◽  
Daniela MANZELLA ◽  
Michelangela BARBIERI ◽  
Maria Rosaria RIZZO ◽  
Antonio GAMBARDELLA ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Frequency ◽  
Low Frequency ◽  
Frequency Component ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous ◽  
Nervous System Activity ◽  
Aged Subjects ◽  
Normalized Units

Healthy centenarians have better anthropometric, endocrine, metabolic and immunological parameters than aged subjects (> 75 years old). Heart rate variability (HRV) has been demonstrated to be a good index of the cardiac autonomic nervous system. It is not known whether there are any differences in cardiac autonomic nervous system activity between aged subjects and healthy centenarians. It is possible that differences in cardiac autonomic nervous system activity could represent one of a cluster of factors explaining the extreme survival of centenarians. Thus we aimed to answer the following question: is there any difference in baseline HRV parameters between aged subjects and healthy centenarians? Therefore power spectral analysis of HRV at baseline was investigated in 25 aged subjects (age ⩾ 75 years) and 30 healthy centenarians (age ⩾ 100 years). Anthropometric measurements were made in all subjects, fasting blood samples were drawn for metabolite determinations, and HRV was determined. Independent of age, gender, body mass index and fasting plasma noradrenaline and free 3,3′,5-tri-iodothyronine concentrations, healthy centenarians had lower basal values for total power (1318±546 compared with 1918±818 ms2; P< 0.01) and the low-frequency component (33±21 compared with 50±11 normalized units; P< 0.03) and a higher value for the high-frequency component (77±15 compared with 61±18 normalized units; P< 0.05) than aged subjects. Consequently, the low-frequency/high-frequency ratio (0.43±0.07 compared with 0.91±0.05; P< 0.02) was also lower in the healthy centenarians than in the aged subjects. Our study demonstrates that the basal low-frequency/high-frequency ratio, an indirect index of cardiac sympathovagal balance, is lower in healthy centenarians than in aged subjects.

scholarly journals Autonomic nervous system activity in purebred Arabian horses evaluated according to the low frequency and high frequency spectrum versus racing performance

2016 ◽  
Vol 85 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Iwona Janczarek ◽  
Witold Kędzierski ◽  
Anna Stachurska ◽  
Izabela Wilk ◽  
Ryszard Kolstrung ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Frequency ◽  
Training Session ◽  
Low Frequency ◽  
Autonomic Nervous System Activity ◽  
System Activity ◽  
Autonomic Nervous ◽  
Nervous System Activity ◽  
Racing Performance

Emotional excitability influences horses’ performance in sports and races. The aim of the study was to analyse whether the balance of the autonomic system which can occur when sympathetic system activity is at various levels might impact the horses’ racing performance. The study was carried out on 67 purebred Arabian horses trained for racing. The following indices were analysed: low frequency (LF), high frequency (HF), and the ratio of spectrum power at low frequencies to high frequencies (LF/HF). The autonomic nervous system activity was measured × 3 during the training season, at three-month intervals. Each examination included a 30-min measurement at rest and after a training session. The racing performance indices in these horses were also analysed. Better racing results were found in horses with enhanced LF/HF. The worst racing results were determined in horses with low LF.

scholarly journals Autonomic Nervous System Responses to Whole-Body Vibration and Mental Workload: A Pilot Study

2019 ◽  
Vol 10 (4) ◽  
pp. 174-184
Author(s):  
Hamed Jalilian ◽  
Zahra Zamanian ◽  
Omid Gorjizadeh ◽  
Shahrzad Riaei ◽  
Mohammad Reza Monazzam ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Frequency ◽  
Mental Workload ◽  
Low Frequency ◽  
Frequency Component ◽  
Whole Body ◽  
Autonomic Nervous ◽  
Rr Interval ◽  
The Mean

Background: Whole-body vibration (WBV) and mental workload (MWL) are common stressors among drivers who attempt to control numerous variables while driving a car, bus, or train. Objective: To examine the individual and combined effects of the WBV and MWL on the autonomic nervous system. Methods: ECG of 24 healthy male students was recorded using NeXus-4 while performing two difficulty levels of a computerized dual task and when they were exposing to WBV (intensity 0.5 m/s2; frequency 3–20 Hz). Each condition was examined for 5 min individually and combined. Inter-beat intervals were extracted from ECG records. The time-domain and frequency-domain heart rate variability parameters were then extracted from the inter-beat intervals data. Results: A significant (p=0.008) increase was observed in the mean RR interval while the participants were exposed to WBV; there was a significant (p=0.02) reduction in the mean RR interval while the participants were performing the MWL. WBV (p=0.02) and MWL significantly (p<0.001) increased the standard deviation of normal-to-normal intervals with a moderate-to-large effect size. All active periods increased the low-frequency component and low-frequency/high-frequency ratio. However, only the WBV significantly increased the highfrequency component. A significant (p=0.01) interaction was observed between the WBV and MWL on low-frequency component and low-frequency/high-frequency ratio. Conclusion: Exposure to WBV and MWL can dysregulate the autonomic nervous system. WBV stimulates both sympathetic and parasympathetic nervous system; MWL largely affects sympathetic nervous system. Both variables imbalance the sympatho-vagal control as well.

scholarly journals Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity

2018 ◽  
Vol 9 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Elias Tsiompanidis ◽  
Spyros I Siakavellas ◽  
Anastasios Tentolouris ◽  
Ioanna Eleftheriadou ◽  
Stamatia Chorepsima ◽  
...  
Keyword(s):  
Nervous System ◽  
Liver Cirrhosis ◽  
Autonomic Nervous System ◽  
Qt Interval ◽  
Autonomic Nervous System Activity ◽  
System Activity ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous ◽  
Nervous System Activity

scholarly journals Autonomic Nervous System Function in Infants With Transposition of the Great Arteries

2011 ◽  
Vol 14 (3) ◽  
pp. 257-268 ◽  
Author(s):  
Tondi M. Harrison ◽  
Roger L. Brown
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Frequency ◽  
Heart Defects ◽  
Newborn Infants ◽  
Low Frequency ◽  
Autonomic Nervous ◽  
Healthy Infants ◽  
Before And After ◽  
High Risk Infants

The ability to maintain and respond to challenges to homeostasis is primarily a function of the autonomic nervous system (ANS). In infants with complex congenital heart defects this ability may be impaired. This study described change in ANS function before and after surgical correction in infants with transposition of the great arteries (TGA) and in healthy infants. A total of 15 newborn infants with TGA were matched with 16 healthy infants on age, gender, and feeding type. The ANS function was measured using heart rate variability (HRV). Data were collected preoperatively in the 1st week of life and postoperatively before, during, and after feeding at 2 weeks and 2 months of age. Infants with TGA demonstrated significantly lower high-frequency and low-frequency HRV preoperatively ( p < .001) when compared with healthy infants. At 2 weeks, infants with TGA were less likely than healthy infants to demonstrate adaptive changes in high-frequency HRV during feeding (Wald Z = 2.002, p = .045), and at 2 months, 40% of TGA infants exhibited delayed postfeeding recovery. Further research is needed to more thoroughly describe mechanisms of a physiologically adaptive response to feeding and to develop nursing interventions supportive of these high-risk infants.

Longitudinal Autonomic Nervous System Measures Correlate With Stress and Ulcerative Colitis Disease Activity and Predict Flare

2020 ◽  
Author(s):  
Robert P Hirten ◽  
Matteo Danieletto ◽  
Robert Scheel ◽  
Mark Shervey ◽  
Jiayi Ji ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Systemic Inflammation ◽  
High Frequency ◽  
Low Frequency ◽  
Fecal Calprotectin ◽  
Cross Sectional ◽  
Autonomic Nervous ◽  
Factor Α

Abstract Background Differences in autonomic nervous system function, measured by heart rate variability (HRV), have been observed between patients with inflammatory bowel disease and healthy control patients and have been associated in cross-sectional studies with systemic inflammation. High HRV has been associated with low stress. Methods Patients with ulcerative colitis (UC) were followed for 9 months. Their HRV was measured every 4 weeks using the VitalPatch, and blood was collected at baseline and every 12 weeks assessing cortisol, adrenocorticotropin hormone, interleukin-1β, interleukin-6, tumor necrosis factor-α, and C-reactive protein (CRP). Stool was collected at enrollment and every 6 weeks for fecal calprotectin. Surveys assessing symptoms, stress, resilience, quality of life, anxiety, and depression were longitudinally collected. Results Longitudinally evaluated perceived stress was significantly associated with systemic inflammation (CRP, P = 0.03) and UC symptoms (P = 0.02). There was a significant association between HRV and stress (low-frequency to high-frequency power [LFHF], P = 0.04; root mean square of successive differences [RMSSD], P = 0.04). The HRV was associated with UC symptoms (LFHF, P = 0.03), CRP (high frequency, P &lt; 0.001; low frequency, P &lt; 0.001; RMSSD, P &lt; 0.001), and fecal calprotectin (high frequency, P &lt; 0.001; low frequency, P &lt; 0.001; RMSSD, P &lt; 0.001; LFHF, P &lt; 0.001). Significant changes in HRV indices from baseline developed before the identification of a symptomatic or inflammatory flare (P &lt; 0.001). Conclusions Longitudinally evaluated HRV was associated with UC symptoms, inflammation, and perceived and physiological measures of stress. Significant changes in HRV were observed before the development of symptomatic or inflammatory flare.

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