Extracellular matrix regulation of drug resistance in small-cell lung cancer

Background/Aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines. Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, and the common dysregulated miRNAs in these cell lines were identified and analyzed by bioinformatics methods. Results: A total of 29 upregulated miRNAs and 36 downregulated miRNAs were found in the drug-resistant NSCLC cell lines, of which 26 upregulated and 36 downregulated miRNAs were found to be involved in the Ras signaling pathway. The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. Conclusion: The results of this study may provide novel biomarkers for drug resistance in NSCLC and potential therapies for overcoming drug resistance, and may also reveal the potential mechanisms underlying drug resistance in this disease.

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PRDM14 Promotes the Migration of Human Non-small Cell Lung Cancer Through Extracellular Matrix Degradation in vitro

Chinese Medical Journal ◽

10.4103/0366-6999.150109 ◽

2015 ◽

Vol 128 (3) ◽

pp. 373-377 ◽

Cited By ~ 11

Author(s):

Hong-Xia Bi ◽

Han-Bing Shi ◽

Ting Zhang ◽

Ge Cui

Keyword(s):

Lung Cancer ◽

Extracellular Matrix ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Matrix Degradation ◽

Small Cell Lung ◽

Extracellular Matrix Degradation

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Mechanisms for acquired cytotoxic drug resistance in human small cell lung cancer and the potential utilization of resistance modifiers — A review with focus on in vitro studies

Lung Cancer ◽

10.1016/0169-5002(90)90254-j ◽

1990 ◽

Vol 6 (1-2) ◽

pp. 9-15 ◽

Cited By ~ 2

Author(s):

Jonas Bergh ◽

Peter Nygren ◽

Rolf Larsson

Keyword(s):

Lung Cancer ◽

Drug Resistance ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Cytotoxic Drug ◽

In Vitro Studies ◽

Small Cell Lung

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Small cell lung cancer transformation during antitumor therapies: A systematic review

Open Medicine ◽

10.1515/med-2021-0321 ◽

2021 ◽

Vol 16 (1) ◽

pp. 1160-1167

Author(s):

Xing Chai ◽

Xinru Zhang ◽

Wenqian Li ◽

Jin Chai

Keyword(s):

Lung Cancer ◽

Drug Resistance ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Treatment Strategies ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancers ◽

Histological Transformation ◽

Nsclc Patients

Abstract Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.

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