scholarly journals Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A

2016 ◽  
Vol 130 (6) ◽  
pp. 451-461 ◽  
Author(s):  
Ryan J. Stark ◽  
Hyehun Choi ◽  
Stephen R. Koch ◽  
Benjamin A. Fensterheim ◽  
Fred S. Lamb ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Lipid A ◽  
Cytokine Production ◽  
Vaccine Adjuvant ◽  
Cell Tolerance ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Potential Use

Monophosphoryl lipid A (MPLA), a vaccine adjuvant, can render endothelial cells tolerant to subsequent challenge by lipopolysaccharide (LPS). Tolerance results in impaired MyD88-dependent signalling, leading to reduced cytokine production. The present study highlights the potential use of immunomodulators to prevent infection-mediated endothelial dysfunction.

The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4

Science ◽  
2007 ◽  
Vol 316 (5831) ◽  
pp. 1628-1632 ◽  
Author(s):  
V. Mata-Haro ◽  
C. Cekic ◽  
M. Martin ◽  
P. M. Chilton ◽  
C. R. Casella ◽  
...  
Keyword(s):  
Lipid A ◽  
Vaccine Adjuvant ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Biased Agonist

scholarly journals Monophosphoryl lipid A inhibits the cytokine response of endothelial cells challenged with LPS

2014 ◽  
Vol 21 (6) ◽  
pp. 565-574 ◽  
Author(s):  
Ryan Stark ◽  
Hyehun Choi ◽  
Stephen Koch ◽  
Fred Lamb ◽  
Edward Sherwood
Keyword(s):  
Endothelial Cells ◽  
Lipid A ◽  
Cytokine Response ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid

scholarly journals Monophosphoryl lipid A alters the inflammatory response of endothelial cells challenged with lipopolysaccharide (855.4)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Ryan Stark ◽  
Hyehun Choi ◽  
Hong Nguyen ◽  
Edward Sherwood ◽  
Fred Lamb
Keyword(s):  
Endothelial Cells ◽  
Inflammatory Response ◽  
Lipid A ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid

Monophosphoryl lipid A directly regulates Th1 cytokine production in human CD4+ T-cells through Toll-like Receptor 2 and 4

Immunobiology ◽  
2021 ◽  
pp. 152132
Author(s):  
Mousa Komai-Koma ◽  
Yuan Ji ◽  
Hui Cao ◽  
Zhigang Liu ◽  
Charles McSharry ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Lipid A ◽  
Cytokine Production ◽  
Toll Like Receptor ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Th1 Cytokine ◽  
Toll Like Receptor 2

scholarly journals Monophosphoryl Lipid A Induces Endotoxin Tolerance in Endothelial Cells

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Ryan Stark ◽  
Stephen Koch ◽  
Fred Lamb ◽  
Edward Sherwood
Keyword(s):  
Endothelial Cells ◽  
Lipid A ◽  
Endotoxin Tolerance ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

Vaccine ◽  
2008 ◽  
Vol 26 (10) ◽  
pp. 1375-1386 ◽  
Author(s):  
Pierre Vandepapelière ◽  
Yves Horsmans ◽  
Philippe Moris ◽  
Marcelle Van Mechelen ◽  
Michel Janssens ◽  
...  
Keyword(s):  
T Cell ◽  
Hepatitis B ◽  
Lipid A ◽  
Healthy Adult ◽  
Hepatitis B Surface Antigen ◽  
Vaccine Adjuvant ◽  
Cell Responses ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Adult Volunteers
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