Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses
Keyword(s):
B Cells
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We have generated a killed Streptococcus pneumoniae whole bacterial cell vaccine, by exposing the bacteria to γ-irradiation. The non-adjuvanted γ-irradiated pneumococcal vaccine provides protection against lethal infection by S. pneumoniae strains of different capsular serotypes.