Remission of Recurrent Cochlear Hydrops Associated With Bromocriptine Treatment for Macroprolactinoma

2019 ◽  
Vol 28 (3) ◽  
pp. 548-552
Author(s):  
Andro Košec ◽  
Ivan Kruljac ◽  
Jakov Ajduk

Objective Current recommendations for cochlear hydrops treatment include systemic glucocorticoids and diuretics. Cochlear cells express dopamine receptors, although their role is unknown in the pathophysiology of cochlear hydrops. Case Description We report the case of remission of recurrent right-sided cochlear hydrops in a young male patient treated with bromocriptine due to pituitary macroprolactinoma. Transient improvement was observed after oral steroid and diuretic treatment, but cochlear hydrops recurred until the dose of bromocriptine was increased to 10 mg daily. Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance.

Author(s):  
Christian Muschitz ◽  
Anita Trummert ◽  
Theresa Berent ◽  
Norbert Laimer ◽  
Lukas Knoblich ◽  
...  

SummarySevere acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), produces protean manifestations and causes indiscriminate havoc in multiple organ systems. This rapid and vast production of proinflammatory cytokines contributes to a condition termed cytokine storm. A 35-year-old, otherwise healthy, employed, male patient was tested positive for COVID-19. He was admitted to the hospital on disease day 10 due to retarded verbal reactions and progressive delirium. On account of these conditions and the need for noninvasive/invasive ventilation, a combination treatment with baricitinib and remdesivir in conjunction with standard of care was initiated. The cytokine storm was rapidly blocked, leading to a vast pulmonary recovery with retarded recovery of the central nervous system. We conclude that the rapid blockade of the COVID-19-induced cytokine storm should be considered of avail as a principle of careful decision-making for effective recovery.


Rheumatology ◽  
1999 ◽  
Vol 38 (11) ◽  
pp. 1158-1159 ◽  
Author(s):  
S. A. W. Fadilah ◽  
S. K. Cheong ◽  
S. Shahdan
Keyword(s):  

2008 ◽  
Vol 117 (4) ◽  
pp. 295-297 ◽  
Author(s):  
Yoav Talmon ◽  
Peter Gilbey ◽  
Nancy Fridman ◽  
Alice Wishniak ◽  
Nathan Roguin

2017 ◽  
Vol 18 (3) ◽  
pp. 172-175
Author(s):  
Sinem Iliaz ◽  
Ece Yurtseven ◽  
Benan Niku Caglayan
Keyword(s):  

2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Swati Singh ◽  
Vaishali Upadhyaya ◽  
Rajat Agarwal ◽  
Ratni B. Gujral

Solitary plasmacytoma of bone without signs of multiple myeloma is a rare entity. It usually presents as an osteolytic lesion in the axial skeleton of an elderly patient. Here, we report a case of solitary plasmacytoma in the skull of a young male patient which emphasises the need to consider it in the differential diagnosis of a destructive calvarial mass lesion even in this age group.


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