Secretion of CSF-1 and its inhibition in rat dental follicle cells, implications for tooth eruption

1998 ◽  
Vol 106 (3) ◽  
pp. 808-815 ◽  
Author(s):  
Robert L. Grier IV ◽  
Lihong Zhao ◽  
Charles E. Adams ◽  
Gary E. Wise
Keyword(s):  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells

Dental Follicle Cells Participate in Tooth Eruption via the RUNX2-MiR-31-SATB2 Loop

2015 ◽  
Vol 94 (7) ◽  
pp. 936-944 ◽  
Author(s):  
J. Ge ◽  
S. Guo ◽  
Y. Fu ◽  
P. Zhou ◽  
P. Zhang ◽  
...  
Keyword(s):  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells

Cellular, Molecular, and Genetic Determinants of Tooth Eruption

2002 ◽  
Vol 13 (4) ◽  
pp. 323-335 ◽  
Author(s):  
G.E. Wise ◽  
S. Frazier-Bowers ◽  
R.N. D’Souza
Keyword(s):  
Mononuclear Cells ◽  
Alveolar Bone ◽  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Genetic Determinants ◽  
Dental Follicle Cells ◽  
Parathyroid Hormone Related Protein ◽  
Molecular Events ◽  
Chemotactic Protein

Tooth eruption is a complex and tightly regulated process that involves cells of the tooth organ and the surrounding alveolus. Mononuclear cells (osteoclast precursors) must be recruited into the dental follicle prior to the onset of eruption. These cells, in turn, fuse to form osteoclasts that resorb alveolar bone, forming an eruption pathway for the tooth to exit its bony crypt. Some of the molecules possibly involved in the signaling cascades of eruption have been proposed in studies from null mice, osteopetrotic rodents, injections of putative eruption molecules, and cultured dental follicle cells. In particular, recruitment of the mononuclear cells to the follicle may require colony-stimulating factor-one (CSF-1) and/or monocyte chemotactic protein-1 (MCP-1). Osteoclastogenesis is needed for the bone resorption and may involve inhibition of osteoprotegerin transcription and synthesis in the follicle, as well as enhancement of receptor activator of NFκB ligand (RANKL), in the adjacent alveolar bone and/or in the follicle. Paracrine signaling by parathyroid-hormone-related protein and interleukin -1α, produced in the stellate reticulum adjacent to the follicle, may also play a role in regulating eruption. Osteoblasts might also influence the process of eruption, the most important physiologic role likely being at the eruptive site, in the formation of osteoclasts through signaling via the RANKL/OPG pathway. Evidence thus far supports a role for an osteoblast-specific transcription factor, Cbfa1 (Runx2), in molecular events that regulate tooth eruption. Cbfa1 is also expressed at high levels by the dental follicle cells. This review concludes with a discussion of the several human conditions that result in a failure of or delay in tooth eruption.

Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption

2002 ◽  
Vol 47 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Gary E Wise ◽  
Shaomian Yao ◽  
Quiyang Zhang ◽  
Yi Ren
Keyword(s):  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells

Parathyroid hormone‐related peptide (1–34) promotes tooth eruption and inhibits osteogenesis of dental follicle cells during tooth development

2018 ◽  
Vol 234 (7) ◽  
pp. 11900-11911 ◽  
Author(s):  
Jiawei Zhang ◽  
Lijun Liao ◽  
Yuyu Li ◽  
Yang Xu ◽  
Weihua Guo ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Tooth Development ◽  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide

scholarly journals The expressions of tooth eruption relevant genes are different in incisors and molars dental follicle cells in rat: an in vitro study

2019 ◽  
Author(s):  
Mengting He ◽  
Xiaomeng Dong ◽  
Peiqi Wang ◽  
Zichao Xiang ◽  
Jiangyue Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Real Time ◽  
Expression Patterns ◽  
In Vitro Study ◽  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells ◽  
Real Time Qpcr

Abstract Background The incisors and molars showed different patterns of tooth eruption in rodents and the dental follicle cells play key roles in tooth eruption. Little is known about the differences in incisors and molars dental follicle cells during tooth eruption in rodents. The purpose of this study was to investigate the differences between incisor dental follicle cells and molar dental follicle cells during tooth eruption in rat.Methods Incisor dental follicle cells and molar dental follicle cells were obtained as previously described. Immunofluorescence was used to identify the cells. Gene expression was measured by real-time qPCR and western blot.Results Compared with molar dental follicle cells, the incisor dental follicle cells showed higher expression of OPG, BMP-2 and BMP-3. The molar dental follicle cells showed higher expression of MCP-1 and RANKL.Conclusions The expression patterns of genes related to tooth eruption were different in incisors and molars dental follicle cells in rat.

Synthesis and Secretion of MCP-1 by Dental Follicle Cells-Implications for Tooth Eruption

1999 ◽  
Vol 78 (11) ◽  
pp. 1677-1681 ◽  
Author(s):  
G.E. Wise ◽  
B.G. Que ◽  
H. Huang
Keyword(s):  
Tooth Eruption ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells

NOTCH1 signaling regulates the BMP2/DLX-3 directed osteogenic differentiation of dental follicle cells

2014 ◽  
Vol 443 (2) ◽  
pp. 500-504 ◽  
Author(s):  
Sandra Viale-Bouroncle ◽  
Martin Gosau ◽  
Christian Morsczeck
Keyword(s):  
Osteogenic Differentiation ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells ◽  
Notch1 Signaling

The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells

2015 ◽  
Vol 406 (1-2) ◽  
pp. 199-204 ◽  
Author(s):  
S. Viale-Bouroncle ◽  
C. Klingelhöffer ◽  
T. Ettl ◽  
C. Morsczeck
Keyword(s):  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Follicle Cells ◽  
Dental Follicle ◽  
Akt Signaling Pathway ◽  
Dental Follicle Cells

WNT5A supports viability of senescent human dental follicle cells

2018 ◽  
Vol 455 (1-2) ◽  
pp. 21-28 ◽  
Author(s):  
Christian Morsczeck ◽  
Anja Reck ◽  
Torsten E. Reichert
Keyword(s):  
Follicle Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells

Cytoskeletal binding proteins distinguish cultured dental follicle cells and periodontal ligament cells

2016 ◽  
Vol 345 (1) ◽  
pp. 6-16 ◽  
Author(s):  
Jie Li ◽  
Hui Li ◽  
Ye Tian ◽  
Yaling Yang ◽  
Guoqing Chen ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Binding Proteins ◽  
Follicle Cells ◽  
Periodontal Ligament Cells ◽  
Dental Follicle ◽  
Dental Follicle Cells
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