Reduced collagenase gene expression in fibroblasts from hypertrophic scar tissue

1996 ◽  
Vol 134 (5) ◽  
pp. 863-868 ◽  
Author(s):  
M. ARAKAWA ◽  
A. HATMOCHI ◽  
Y. MORI ◽  
K. MORI ◽  
H. UEKI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue ◽  
Collagenase Gene

Reduced collagenase gene expression in fibroblasts from hypertrophic scar tissue

1996 ◽  
Vol 134 (5) ◽  
pp. 863-868 ◽  
Author(s):  
M. ARAKAWA ◽  
A. HATMOCHI ◽  
Y. MORI ◽  
K. MORI ◽  
H. UEKI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue ◽  
Collagenase Gene

Gene Expression of Early Hypertrophic Scar Tissue Screened by Means of cDNA Microarrays

2004 ◽  
Vol 57 (6) ◽  
pp. 1276-1286 ◽  
Author(s):  
Jun Wu ◽  
Bing Ma ◽  
Shaoxuan Yi ◽  
Zhenxiang Wang ◽  
Weifeng He ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hypertrophic Scar ◽  
Cdna Microarrays ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue

scholarly journals Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway

2015 ◽  
Vol 37 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Ting He ◽  
Xiaozhi Bai ◽  
Longlong Yang ◽  
Lei Fan ◽  
Yan Li ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Ex Vivo ◽  
Scar Tissue ◽  
Scar Formation ◽  
Jnk Pathway ◽  
Protein Levels ◽  
Mapk Inhibitors ◽  
Hypertrophic Scar Tissue ◽  
Loureirin B ◽  
Tgf Β1

Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown. Methods: Immunohistochemistry was used to detect expression of Col1, FN and TGF-β1 in skin and scar tissue. Fibroblasts were stimulated with TGF-β1 to mimic scar formation. LB or MAPK inhibitors were used to study the pathways involved in the process. Western blotting was used to evaluate the expression of p-JNK, p-ERK, p-p38, Col1 and FN. The contractile capacity of fibroblasts was evaluated using a gel contraction assay. Tissues were cultured ex vivo with LB to further investigate the participation of ERK and JNK in the LB-mediated inhibition of scar formation. Results: FN and Col1 were up regulated in hypertrophic scars. LB down regulated p-ERK and p-JNK in TGF-β1-stimulated fibroblasts, while levels of phosphorylated p38 did not change. The down regulation of p-ERK and p-JNK was associated with a reduction of Col1 and FN. Similarly, inhibition of ERK and JNK down regulated the expression of Col1 and FN in TGF-β1-stimulated fibroblasts. LB down regulated protein levels of p-ERK and p-JNK in cultured hypertrophic scar tissue ex vivo. Conclusions: This study suggests that LB can inhibit scar formation through the ERK/JNK pathway.

The Use of Silicone Gel Sheets in the Control of Hypertrophic Scar Tissue

1988 ◽  
Vol 51 (7) ◽  
pp. 248-249 ◽  
Author(s):  
Rosemary Gollop
Keyword(s):  
Retrospective Study ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
City Hospital ◽  
Hypertrophic Scarring ◽  
The Past ◽  
Silicone Gel ◽  
Clinical Observations ◽  
Hypertrophic Scar Tissue ◽  
Indications For Use

For the past 3 years, Nottingham City Hospital Burns and Plastic Surgery Unit have been using silicone gel in addition to, or as an alternative to, accepted methods of treating hypertrophic scarring. This paper outlines the history, properties and indications for use of silicone gel. Its findings result from a retrospective study based largely on clinical observations.

In vitro study of ethosome penetration in human skin and hypertrophic scar tissue

2012 ◽  
Vol 8 (6) ◽  
pp. 1026-1033 ◽  
Author(s):  
Zhen Zhang ◽  
Yan Wo ◽  
Yixin Zhang ◽  
Danru Wang ◽  
Rong He ◽  
...  
Keyword(s):  
Human Skin ◽  
Hypertrophic Scar ◽  
In Vitro Study ◽  
Scar Tissue ◽  
Vitro Study ◽  
Hypertrophic Scar Tissue

scholarly journals High-Efficiency Expression of TAT-bFGF Fusion Protein in Escherichia coli and the Effect on Hypertrophic Scar Tissue

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117448 ◽  
Author(s):  
Xuechao Jia ◽  
Haishan Tian ◽  
Lu Tang ◽  
Long Zheng ◽  
Lulu Zheng ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Fusion Protein ◽  
Hypertrophic Scar ◽  
High Efficiency ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue
Sign in / Sign up

Export Citation Format

Share Document