scholarly journals Serial monitoring of BCR-ABL by peripheral blood real-time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia

2002 ◽  
Vol 118 (3) ◽  
pp. 771-777 ◽  
Author(s):  
Lihui Wang ◽  
Kevin Pearson ◽  
Lynne Pillitteri ◽  
Julia E. Ferguson ◽  
Richard E. Clark
Keyword(s):  
Polymerase Chain Reaction ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Real Time ◽  
Imatinib Mesylate ◽  
Peripheral Blood ◽  
Cytogenetic Response ◽  
Chain Reaction ◽  
Polymerase Chain

scholarly journals Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis

2018 ◽  
Vol 90 (3) ◽  
pp. 21-24
Author(s):  
I E Malysheva ◽  
O V Balan ◽  
E L Tikhonovich ◽  
T O Volkova
Keyword(s):  
Gene Expression ◽  
Polymerase Chain Reaction ◽  
Real Time ◽  
Peripheral Blood ◽  
Messenger Rna ◽  
Peripheral Blood Leukocytes ◽  
Chain Reaction ◽  
Blood Leukocytes ◽  
Healthy Donors ◽  
Polymerase Chain

Aim. To study the expression level of the genes DROSHA and DICER in peripheral blood leukocytes (PBL) of patients with sarcoidosis of the lungs Materials and methods. The study included 32 patients diagnosed with persistent lung sarcoidosis (mean age 41.56±1.27 years) and 36 healthy donors (control; mean age 42.79±1.95 years). The level of expression of messenger RNA (mRNA) of the genes DROSHA and DICER were determined in PBL of healthy donors and patients with sarcoidosis of the lung by polymerase chain reaction in real time. Results. As a result of the conducted researches it is established that the level of drosha gene expression in PBL patients with sarcoidosis of lungs is significantly reduced in comparison with the control (p

scholarly journals Chronic myeloid leukaemia with pulmonary leucostasis in a young Down syndrome patient

2020 ◽  
Vol 29 (3) ◽  
pp. 203-205
Author(s):  
Mohd Jazman bin Che Rahim ◽  
Hany Haqimi bin Wan Hanafi ◽  
Muhammad Imran bin Kamaruddin ◽  
Azlan bin Husin
Keyword(s):  
Down Syndrome ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Peripheral Blood ◽  
Multiple Organ ◽  
Chain Reaction ◽  
Down Syndrome Patient ◽  
Cytogenetic Studies ◽  
Ph Chromosome ◽  
Polymerase Chain

We reported a rare case of chronic myeloid leukaemia (CML) complicated with pulmonary leucostasis in an 11-year-old Down syndrome (DS) patient who presented with respiratory distress. His peripheral blood investigation showed features of CML with 17% circulating blast, with immunophenotyping showing positivity towards myeloid markers. Peripheral blood polymerase chain reaction for BCR–ABL fusion transcripts was positive, and cytogenetic studies showed Ph chromosome with trisomy 21. Despite cytoreduction therapy with hydroxyurea and leukapheresis, the patient succumbed due to shock, with multiple organ failure. Our case highlights the need for early detection and rapid referral for aggressive treatment in DS patients with CML, as the combination is associated with a poor outcome.

Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: Accurate quantification using real-time polymerase chain reaction

2003 ◽  
Vol 48 (5) ◽  
pp. 1223-1228 ◽  
Author(s):  
Nathalie Balandraud ◽  
Jean Baptiste Meynard ◽  
Isabelle Auger ◽  
Helene Sovran ◽  
Benedicte Mugnier ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Polymerase Chain Reaction ◽  
Real Time ◽  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Chain Reaction ◽  
Barr Virus ◽  
Polymerase Chain ◽  
Epstein Barr ◽  
Accurate Quantification
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