The Novel Arylamidine T-2307 MaintainsIn VitroandIn VivoActivity against Echinocandin-Resistant Candida albicans
2014 ◽
Vol 59
(2)
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pp. 1341-1343
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ABSTRACTWe evaluated thein vitroandin vivoactivities of the investigational arylamidine T-2307 against echinocandin-resistantCandida albicans. T-2307 demonstrated potentin vitroactivity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistantC. albicansinfections.
2014 ◽
Vol 59
(1)
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pp. 690-692
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2012 ◽
Vol 57
(1)
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pp. 445-451
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2012 ◽
Vol 56
(6)
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pp. 3207-3215
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2016 ◽
Vol 60
(5)
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pp. 3152-3155
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