Apolipoprotein E polymorphisms and mortality in Italian Type 2 diabetic patients

2003 ◽  
Vol 33 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M. Boemi ◽  
C. Sirolla ◽  
R. Testa ◽  
F. Gregorio ◽  
G. Brandoni ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Evaluation of apolipoprotein E secretion by macrophages in type 2 diabetic patients: role of HDL and apolipoprotein A-I

2005 ◽  
Vol 69 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Kazumi Yamato ◽  
Naoki Tamasawa ◽  
Hiroshi Murakami ◽  
Jun Matsui ◽  
Jutaro Tanabe ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Apolipoprotein A ◽  
Type 2 Diabetic

Apolipoprotein E genetic polymorphism, remnant lipoproteins, and nephropathy in type 2 diabetic patients

2002 ◽  
Vol 40 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Masaaki Eto ◽  
Mieko Saito ◽  
Mizuho Okada ◽  
Yoshie Kume ◽  
Fumiko Kawasaki ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Apolipoprotein E ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Remnant Lipoproteins ◽  
Type 2 Diabetic

Relationship between Apolipoprotein E polymorphism and nephropathy in type-2 diabetic patients

2007 ◽  
Vol 78 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Elba Leiva ◽  
Verónica Mujica ◽  
Isabel Elematore ◽  
Roxana Orrego ◽  
Gonzalo Díaz ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Apolipoprotein E Polymorphism ◽  
Type 2 Diabetic

Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile

2005 ◽  
Vol 68 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Elba Leiva ◽  
Verónica Mujica ◽  
Roxana Orrego ◽  
María Prieto ◽  
Miguel Arredondo
Keyword(s):  
Apolipoprotein E ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Apolipoprotein E Polymorphism ◽  
Type 2 Diabetic

scholarly journals Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
YongWei Jiang ◽  
Liang Ma ◽  
ChengWu Han ◽  
Qian Liu ◽  
Xiao Cong ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Polymorphism ◽  
Apolipoprotein E ◽  
Group Versus ◽  
Allelic Frequency ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients. We studied 845 diabetic patients who were divided into DN group (n=429) and control group (n=416). ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences (P<0.001) in HbA1c, creatinine, and urinary albumin between the two groups. The ApoEε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41–3.47, andP<0.05), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%,P<0.05). The ApoEε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50–0.97, andP<0.05), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%,P<0.05). These results suggest ApoEε2 allele may be a risk factor; however ApoEε4 allele may play a protective role of DN in Chinese type 2 diabetic patients.

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