scholarly journals Regulation of gene expression, cellular localization, and in vivo function of Caenorhabditis elegans DNA topoisomerase I

2001 ◽  
Vol 6 (4) ◽  
pp. 303-312 ◽  
Author(s):  
Myon Hee Lee ◽  
Hyungki Park ◽  
Gaegal Shim ◽  
Junho Lee ◽  
Hyeon-Sook Koo
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Topoisomerase I ◽  
Cellular Localization ◽  
Regulation Of Gene Expression ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

cDNA Cloning, Expression, and Chromosomal Localization of Caenorhabditis elegans DNA Topoisomerase I

1996 ◽  
Vol 237 (2) ◽  
pp. 367-372 ◽  
Author(s):  
Jonghwa Kim ◽  
You-Chan Kim ◽  
Jong Hyouk Lee ◽  
Yeon Joo Jang ◽  
In Kwon Chung ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Cdna Cloning ◽  
Topoisomerase I ◽  
Chromosomal Localization ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

scholarly journals Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo

2008 ◽  
Vol 409 (3) ◽  
pp. 651-656 ◽  
Author(s):  
Francesca Di Felice ◽  
Francesco Chiani ◽  
Giorgio Camilloni
Keyword(s):  
Topoisomerase I ◽  
Basic Question ◽  
Dna Topoisomerase I ◽  
Physical Barrier ◽  
Dna Topoisomerase ◽  
Histone Octamer ◽  
Cleavage Activity ◽  
Cellular Dna

DNA topoisomerase I together with the other cellular DNA topoisomerases releases the torsional stress from DNA caused by processes such as replication, transcription and recombination. Despite the well-defined knowledge of its mechanism of action, DNA topoisomerase I in vivo activity has been only partially characterized. In fact the basic question concerning the capability of the enzyme to cleave and rejoin DNA wrapped around a histone octamer remains still unanswered. By studying both in vivo and in vitro the cleavage activity of DNA topoisomerase I in the presence of camptothecin on a repeated trinucleotide sequence, (TTA)35, lying in chromosome XIII of Saccharomyces cerevisiae, we can conclude that nucleosomes represent a physical barrier for the enzyme activity.

DNA Topoisomerase I and Cell Proliferation: Analysis of top1 Gene Expression in Different Carrot Tissues

1995 ◽  
Vol 129 (4) ◽  
pp. 933-934
Author(s):  
Alma Balestrazzi ◽  
Ilaria Toscano ◽  
Mei-Zhong Luo ◽  
Giovanni Bernacchia ◽  
Daniela Carbonera
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats

2010 ◽  
Vol 5 (3) ◽  
pp. 321-327 ◽  
Author(s):  
Stephan W. Barth ◽  
Karlis Briviba ◽  
Bernhard Watzl ◽  
Nicole Jäger ◽  
Doris Marko ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
In Vivo Bioassay
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