Though there have been extended deliberations for making information systems (IS) research more relevant1 and useful for IS executives, to our knowledge, there has been no empirical study which examines the extent of relevance in the current IS research. In this chapter, we analyze the topical relevance of 388 published academic articles in the three top IS journals: MIS Quarterly (MISQ), Information Systems Research (ISR), and Journal of Management Information Systems (JMIS), for a 5 year period from 2000-2004. We do this by examining their fit with the key issues for information technology (IT) executives identified by the latest Society for Information Management (SIM) survey. Based on our results, we make recommendations for making IS research more meaningful for practitioners.