scholarly journals Transfer of T-DNA and Vir proteins to plant cells by Agrobacterium tumefaciens induces expression of host genes involved in mediating transformation and suppresses host defense gene expression

2003 ◽  
Vol 35 (2) ◽  
pp. 219-236 ◽  
Author(s):  
Hongmei Jiang ◽  
R.W. Doerge ◽  
Stanton B. Gelvin
Keyword(s):  
Gene Expression ◽  
Agrobacterium Tumefaciens ◽  
Host Defense ◽  
Plant Cells ◽  
Defense Gene Expression ◽  
Defense Gene ◽  
Vir Proteins ◽  
Host Genes

scholarly journals Constitutive expression of clathrin hub hinders elicitor-induced clathrin-mediated endocytosis and defense gene expression in plant cells

FEBS Letters ◽  
2012 ◽  
Vol 586 (19) ◽  
pp. 3293-3298 ◽  
Author(s):  
T. Adam ◽  
K. Bouhidel ◽  
C. Der ◽  
F. Robert ◽  
A. Najid ◽  
...  
Keyword(s):  
Gene Expression ◽  
Constitutive Expression ◽  
Plant Cells ◽  
Defense Gene Expression ◽  
Defense Gene

scholarly journals HOS15 is a transcriptional corepressor of NPR1-mediated gene activation of plant immunity

2020 ◽  
Vol 117 (48) ◽  
pp. 30805-30815
Author(s):  
Mingzhe Shen ◽  
Chae Jin Lim ◽  
Junghoon Park ◽  
Jeong Eun Kim ◽  
Dongwon Baek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ubiquitin Ligase ◽  
Transcriptional Activation ◽  
Plant Immunity ◽  
Gene Activation ◽  
Transcriptional Corepressor ◽  
Defense Gene Expression ◽  
Dynamic Regulation ◽  
Defense Gene ◽  
Transcriptional Corepressors

Transcriptional regulation is a complex and pivotal process in living cells. HOS15 is a transcriptional corepressor. Although transcriptional repressors generally have been associated with inactive genes, increasing evidence indicates that, through poorly understood mechanisms, transcriptional corepressors also associate with actively transcribed genes. Here, we show that HOS15 is the substrate receptor for an SCF/CUL1 E3 ubiquitin ligase complex (SCFHOS15) that negatively regulates plant immunity by destabilizing transcriptional activation complexes containing NPR1 and associated transcriptional activators. In unchallenged conditions, HOS15 continuously eliminates NPR1 to prevent inappropriate defense gene expression. Upon defense activation, HOS15 preferentially associates with phosphorylated NPR1 to stimulate rapid degradation of transcriptionally active NPR1 and thus limit the extent of defense gene expression. Our findings indicate that HOS15-mediated ubiquitination and elimination of NPR1 produce effects contrary to those of CUL3-containing ubiquitin ligase that coactivate defense gene expression. Thus, HOS15 plays a key role in the dynamic regulation of pre- and postactivation host defense.

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