TARGET GENES OF THE WILMS' TUMOUR SUPPRESSOR GENE AS IDENTIFIED BY cDNA EXPRESSION PROFILING

Nephrology ◽  
2002 ◽  
Vol 7 (1) ◽  
pp. A5-A5
Author(s):  
Little M.H ◽  
Forrest A ◽  
Grimmond S ◽  
Lindsay M ◽  
Martinez G ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Target Genes ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour ◽  
Cdna Expression

Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1

Gene ◽  
1995 ◽  
Vol 167 (1-2) ◽  
pp. 239-243 ◽  
Author(s):  
Andrew Ward ◽  
Jo-Anna Pooler ◽  
Kiyoshi Miyagawa ◽  
Antonio Duarte ◽  
Nicholas D. Hastie ◽  
...  
Keyword(s):  
Growth Factor ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Insulin Like Growth Factor ◽  
Wilms Tumour ◽  
Factor Ii ◽  
Encoding Gene ◽  
By Products

scholarly journals Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2

Oncogene ◽  
1997 ◽  
Vol 14 (22) ◽  
pp. 2689-2700 ◽  
Author(s):  
Melanie J McConnell ◽  
Heather E Cunliffe ◽  
Lin J Chua ◽  
Teresa A Ward ◽  
Michael R Eccles
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Differential Regulation ◽  
Tumour Suppressor ◽  
Wilms Tumour

scholarly journals Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer

Oncogene ◽  
2002 ◽  
Vol 21 (47) ◽  
pp. 7277-7282 ◽  
Author(s):  
Kate J Wagner ◽  
Wendy N Cooper ◽  
Richard G Grundy ◽  
Germaine Caldwell ◽  
Carolyn Jones ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Promoter Methylation ◽  
Gene Promoter ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour

The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

2008 ◽  
Vol 36 (4) ◽  
pp. 629-631 ◽  
Author(s):  
Jörg Hartkamp ◽  
Stefan G.E. Roberts
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour ◽  
Zinc Finger Transcription Factor ◽  
Tumour Suppressor Protein ◽  
Proliferation And Apoptosis

The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.

scholarly journals New Wilms' tumour suppressor gene (WT1) functions revealed by YAC transgenic analysis

1998 ◽  
Vol 72 (1) ◽  
pp. 59-72
Author(s):  
A. MOORE ◽  
A. SCHEDL ◽  
L. McINNES ◽  
J. KREIDBERG ◽  
R. JAENISCH ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour

DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter

2009 ◽  
Vol 422 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Hanshao Liu ◽  
Hoi Chin Hew ◽  
Zheng-Guang Lu ◽  
Tomoko Yamaguchi ◽  
Yoshio Miki ◽  
...  
Keyword(s):  
Dna Damage ◽  
Target Genes ◽  
Core Promoter ◽  
Genotoxic Stress ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Dependent Manner ◽  
P53 Expression ◽  
Protein Levels

Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of various target genes involved in the DNA damage response. However, the molecular basis of this regulation remains obscure. In the present study we demonstrate that RREB-1 (Ras-responsive-element-binding protein-1) efficiently binds to the p53 promoter via the p53 core promoter element and transactivates p53 expression. Silencing of RREB-1 significantly reduces p53 expression at both the mRNA and the protein levels. Notably, disruption of RREB-1-mediated p53 transcription suppresses the expression of the p53 target genes. We also show that, upon exposure to genotoxic stress, RREB-1 controls apoptosis in a p53-dependent manner. These findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage.

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