Factors influencing the development of hemolytic uremic syndrome caused by enterohemorrhagic Escherichia coli infection: From a questionnaire survey to in vitro experiment

1999 ◽  
Vol 41 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Takeshi Honda
1992 ◽  
Vol 30 (8) ◽  
pp. 2153-2157 ◽  
Author(s):  
A Cordovéz ◽  
V Prado ◽  
L Maggi ◽  
J Cordero ◽  
J Martinez ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73927 ◽  
Author(s):  
Monika Marejková ◽  
Květa Bláhová ◽  
Jan Janda ◽  
Angelika Fruth ◽  
Petr Petráš

Cytokine ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 694-700 ◽  
Author(s):  
Masaki Shimizu ◽  
Mondo Kuroda ◽  
Natsumi Sakashita ◽  
Michio Konishi ◽  
Hisashi Kaneda ◽  
...  

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Sabrina Mühlen ◽  
Isabell Ramming ◽  
Marina C. Pils ◽  
Martin Koeppel ◽  
Jana Glaser ◽  
...  

ABSTRACT Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the disease derives from the release of Shiga toxins (Stx). The use of antibiotics to treat EHEC infections is generally avoided, as it can result in increased stx expression. Here, we systematically tested different classes of antibiotics and found that their influence on stx expression and release varies significantly. We assessed a selection of these antibiotics in vivo using the Citrobacter rodentium ϕstx2dact mouse model and show that stx2d-inducing antibiotics resulted in weight loss and kidney damage despite clearance of the infection. However, several non-Stx-inducing antibiotics cleared bacterial infection without causing Stx-mediated pathology. Our results suggest that these antibiotics might be useful in the treatment of EHEC-infected human patients and decrease the risk of HUS development.


1996 ◽  
Vol 155 (7) ◽  
pp. 592-595 ◽  
Author(s):  
Nicole C. A. J. van de Kar ◽  
Hannie G. R. Roelofs ◽  
Harry L. Muytjens ◽  
Jules J. M. Tolboom ◽  
Bernhard Roth ◽  
...  

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