Improvement in Migraine-Specific Quality of Life in A Clinical Trial of Rizatriptan

Cephalalgia ◽  
1997 ◽  
Vol 17 (8) ◽  
pp. 867-872 ◽  
Author(s):  
NC Santanello ◽  
AB Polis ◽  
SL Hartmaier ◽  
MS Kramer ◽  
GA Block ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Functional Disability ◽  
Controlled Clinical Trial ◽  
Life Questionnaire ◽  
Test Statistic ◽  
Related Quality ◽  
Health Related ◽  
The Impact

A validated migraine-specific questionnaire (24-h Migraine Quality of Life Questionnaire1: 24-h MQoLQ) was used to assess the impact of migraine and migraine therapy on health related quality of life during an acute migraine attack. Male and female migraineurs aged 18-55 years were randomized to placebo ( n = 41), rizatriptan 2.5 mg ( n = 47), 5 mg ( n = 74), or 10 mg ( n = 85) in a triple-blind, placebo-controlled clinical trial. Rizatriptan 5 mg and 10 mg were significantly more efficacious than placebo on pain relief and functional disability. After accounting, for multiple comparisons to placebo, rizatriptan 10 mg showed significantly better responses compared to placebo on three of five domains of 24-h MQoLQ (social functioning, migraine symptoms, and feelings/concerns). The O'Brien's Rank Sum Test statistic showed a statistically significant overall difference on the 24-h MQoLQ between the 10 mg rizatriptan and placebo groups ( p = 0.005) and for the overall close trend ( p 0.001).

Chewing ability and oral health‐related quality of life in frail elders after new complete dentures insertion: A paired controlled clinical trial

2020 ◽  
Vol 40 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Olívia Maria Costa Figueredo ◽  
Mariana Barbosa Câmara‐Souza ◽  
Talita Malini Carletti ◽  
Renata Cunha Matheus Rodrigues Garcia
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Complete Dentures ◽  
Health Related Quality ◽  
Frail Elders ◽  
Chewing Ability ◽  
Related Quality ◽  
Health Related

Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy

2008 ◽  
Vol 26 (22) ◽  
pp. 3770-3776 ◽  
Author(s):  
Johannes A. Langendijk ◽  
Patricia Doornaert ◽  
Irma M. Verdonck-de Leeuw ◽  
Charles R. Leemans ◽  
Neil K. Aaronson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck ◽  
Radiation Therapy Oncology Group ◽  
Life Questionnaire ◽  
Related Quality ◽  
Health Related ◽  
Late Treatment ◽  
Radiation Induced ◽  
The Impact

Purpose To investigate the impact of treatment-related toxicity on health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma treated with radiotherapy either alone or in combination with chemotherapy or surgery. Patients and Methods The study sample was composed of 425 disease-free patients. Toxicity was scored according to the European Organisation for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) late radiation-induced morbidity scoring system. HRQoL was assessed using the EORTC Quality of Life Questionnaire C30. These assessments took place at 6, 12, 18, and 24 months after completion of radiotherapy. The analysis was performed using a multivariate analysis of variance. Results Of the six RTOG scales investigated, two significantly affected self-reported HRQoL, salivary gland (RTOGxerostomia) and esophagus/pharynx (RTOGswallowing). Although RTOGxerostomia was reported most frequently, HRQoL was most affected by RTOGswallowing, particularly in the first 18 months after completion of radiotherapy. Conclusion Late radiation-induced toxicity, particularly RTOGswallowing and RTOGxerostomia, has a significant impact on the more general dimensions of HRQoL. These findings suggest that the development of new radiation-induced delivery techniques should not only focus on reduction of the dose to the salivary glands, but also on anatomic structures that are involved in swallowing.

scholarly journals The Influence of Friction on Design of the Type of Bracket and Its Relation to OHRQoL in Patients Who Use Multi-Bracket Appliances: A Randomized Clinical Trial

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 171
Author(s):  
Adriana González-Sáez ◽  
Laura Antonio-Zancajo ◽  
Javier Montero ◽  
Alberto Albaladejo ◽  
María Melo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Oral Health ◽  
Randomized Clinical Trial ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Bonferroni Test ◽  
The Impact

Background and objectives: The aim of this study was to evaluate the influence of friction on design of the type of bracket, patients’ perception of pain and the impact on their oral health-related quality of life. Materials and Methods: A randomized clinical trial was carried out with 90 patients (62.2% women and 37.8% men) with three kinds of fixed multi-bracket appliances: Conventional (GC), fixed multi-bracket low friction (GS) and self-ligating (GA). The VAS (Visual Analogue Scale) was used to determine pain during the first seven days of treatment at different points in time. The patients were also given the OHIP-14 (Oral Health Impact Profile) questionnaire to analyse their oral health-related quality of life (OHRQoL) after the first 30 days of treatment. The ANOVA test was used for the analysis of the variables and the post hoc Bonferroni test for the comparison between groups. Results: Maximum pain was observed between one and two days after the start of treatment. The GC group showed the greatest degree of pain, with maximum values (4.5 ± 2.0) at 24 h. The self-ligation brackets show lower impact on patients’ oral health-related quality of life (0.8 ± 2.2, p < 0.01). Conclusions: Friction in the type of bracket influences pain and the Oral Health-Related Quality of Life of patients who use multi-bracket fixed orthodontics.

scholarly journals Effects of Linear and Non-periodized Combined Training on Health-related Quality of Life of Adults With Obesity: a Randomized Clinical Trial

2021 ◽  
Author(s):  
Willen Remon Tozetto ◽  
Larissa dos Santos Leonel ◽  
Tiago Turnes ◽  
Giovani Firpo Del Duca
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Health Related Quality ◽  
Combined Training ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Abstract Background: Health-related quality of life (HRQoL) is impaired by obesity and can be improved by combined training, even the effects of training periodization on HRQoL are not clear. The study aimed to compare combined training with the non-periodized and the linear periodization on HRQoL of obese adults. Methods: This is a blinded, controlled clinical trial involving adults with obesity (BMI ≥ 30 kg/m²), randomized into control (CG), non-periodized (NG) and linear periodization (PG) group. Three times a week for 16 weeks, NG and PG performed combined training for 60 minutes. The NG performed aerobic exercises between 50-59% of the reserve heart rate (HRres) and strength at 10-12 maximum repetitions (MR). The PG started with 40-49% of HRres and 12-14 MRs and progressively increased the intensity (50-59% and 10-12 MRs; 60-69% and 8-10 MRs) with total volume equalized with NG. HRQoL was investigated through the SF-36 questionnaire, according to its components and domains. In statistics, Generalized Estimation Equations and mean differences (∆) were used. Results: Of the 69 participants (23 in each group), 36 completed the intervention (CG=13, NG=9 and PG=14). A significant difference was observed in time of physical function, with superiority in training groups (CG:∆=1.2 vs NG and PG, respectively: ∆=10.0). The mental component and mental health domain showed a significant difference for NG (∆=30.2 and ∆=23.1, respectively). Conclusion: The combined training was able to bring benefits to the physical functioning of adults with obesity and, specifically, the non-periodized training improved mental health indicators effectively.Clinical Trial Registry: RBR-3c7rt3 Date of Registration: 07/02/2018

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